Clinical and Translational Science Core

临床和转化科学核心

• 批准号: 10595081
• 负责人: David J. Horne
• 金额: $ 6.99万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595081
• 关键词: Africa South of the Sahara; Area; Asia; Authorization documentation; Biological; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Collection; Consultations; Country; Data; Databases; Diagnostic; Disease; Disease model; Educational process of instructing; Faculty; Fostering; Goals; Grant; Individual; Institution; International; Latin America; Mentors; Methodology; Methods; Minority Groups; Modeling; Outcome; Persons; Pharmaceutical Preparations; Pilot Projects; Productivity; Protocols documentation; Public Health; Research; Research Activity; Research Methodology; Research Personnel; Research Support; Resources; Series; Services; Site; Specimen; Structure; Training; Translational Research; Translations; Travel; Tuberculosis; Tuberculosis Vaccines; Underrepresented Minority; Universities; Vaccines; Washington; authority; biobank; clinical database; clinical epidemiology; cohort; global health; graduate student; implementation science; meetings; multidisciplinary; novel; programs; prospective; sample collection; summer research; transmission process; working group

PROJECT SUMMARY (CLINICAL AND TRANSLATIONAL SCIENCE CORE) The WHO’s “End TB Strategy” will require novel TB vaccines, drugs, and diagnostics, along with advances in clinical research methods and modeling, a new cadre of clinical researchers, strengthened domestic and international collaborations, and access to biospecimens. The University of Washington (UW) excels in conducting research in clinical epidemiology, clinical trials, implementation science, and disease modeling, while also developing strong global health programs and partnerships in TB-endemic countries. The Clinical and Translational Science Core (“CTSC”) will educate and train new and early-stage investigators, including people working in TB-endemic countries, and individuals from underrepresented minority groups, in critical areas of clinical TB research. The CTSC will coordinate with the other SEA-TRAC Cores to leverage the multi-disciplinary expertise available and engage non-TB investigators who may bring novel perspectives and advanced methods to TB research. The CTSC will leverage existing biorepositories to catalyze TB research and generate preliminary data using the vast UW research network that includes field sites in Latin America, sub-Saharan Africa, and Asia. The CTSC will be to provide expertise for a broad array of clinical research topics, provide shared research support for resources, services and training, and to strengthen TB clinical research through domestic and international collaborations through three specific aims: (1) to strengthen clinical and translational TB research through training and consultation in clinical science methodology and support of local collaborations; (2) to strengthen TB clinical research by developing and expanding partnerships with national and international collaborators conducting clinical and translational research in TB; and (3) Aim 3. To foster and catalyze collaborations with investigators with established cohorts, robust clinical databases, and biospecimens for advancing basic, translation, and clinical TB research. The CTSC will also maintain an intensive one-week advanced TB research summer course. Overall, the CTSC will foster collaborations between SEA-TRAC investigators and authorizing investigators, which will lead to more productive and efficient research, an increase in generated pilot study data, and more collaborative TB grant submissions over a 5-year period.

项目摘要（临床和转化科学核心） 世卫组织的“结核病策略”将需要新颖的结核病疫苗，药物和诊断，并进展 临床研究方法和建模是新的临床研究人员干部，加强了国内和 国际合作，并获得生物测量。华盛顿大学（UW）擅长 从事临床流行病学，临床试验，实施科学和疾病建模的研究，而 还在结核病国家建立强大的全球健康计划和合作伙伴关系。临床和 翻译科学核心（“ CTSC”）将教育和培训新的和早期的调查人员，包括人们 在结核病国家和来自代表性不足的少数群体的个人在关键领域工作 临床结核病研究。 CTSC将与其他Sea-Trac核心协调以利用多学科 可用的专业知识并吸引非结核病调查人员，他们可能会带来新颖的观点和高级方法 进行结核病研究。 CTSC将利用现有的生物剂量来催化结核病研究并产生 使用庞大的UW研究网络的初步数据，该网络包括拉丁美洲，撒哈拉以南的现场网站 非洲和亚洲。 CTSC将为各种临床研究主题提供专业知识，提供 共享对资源，服务和培训的研究支持，并通过 通过三个特定目标进行国内和国际合作：（1）加强临床和翻译 结核病研究通过临床科学方法论的培训和咨询和当地合作的支持； （2）通过与国家和国际建立和扩大合作伙伴关系来加强结核病临床研究 进行临床和翻译研究的合作者； （3）目标3。促进和催化 与研究人员与已建立的同伙，强大的临床数据库和生物测量合作 推进基本，翻译和临床结核病研究。 CTSC还将维持一个密集的一周 高级结核病研究夏季课程。总体而言，CTSC将促进Sea-Trac之间的合作 调查人员和授权调查人员将导致提高生产力和高效的研究 在生成的试点研究数据中，以及在5年期间进行的更多协作结核病赠款提交。