Physician Scientist Training in Age-Related Diseases

摘要 这一新的T32博士后培训基金的目标是培养优秀的内科科学家 在与年龄相关的条件下独立工作。我们将在医院招聘内科科学家实习生。 完成临床培训，并在开始独立研究生涯之前。给定 全球老年人数量不断增加，与健康有关的老年人问题将主导健康 关爱景观。内科医生-科学家已经做好准备，进行与老年人相关的翻译研究 因为他们能够理解临床前研究的临床意义，并具有独特的能力 确定可能对临床护理产生重大影响的研究领域。密歇根大学 (UM)处于独特的地位，可以像UM一样在年龄相关研究方面培训有前途的内科科学家 在老年科学/老龄生物学、老年医学、临床医学和卫生政策研究方面开展了强有力的计划。 为了在与年龄相关的条件下培训转化医学的内科科学家，我们将包括导师。 代表了从临床前研究到研究的转化型医学研究的光谱 在健康和患病的人类受试者中(即，翻译)，公共政策和人口健康。这个 这个项目的主任(莫迪博士)和两位联席主任(戈尔茨坦博士和敏博士)都是医生- 在这项翻译研究中，科学家们研究了与年龄相关的疾病的各个方面 频谱。莫迪博士是一位临床干预主义者，他与研究人员有积极的合作 在医疗保健研究政策中向科学家进行基础基因组研究。戈尔茨坦博士研究了 衰老通过使用动脉粥样硬化、流感病毒感染、 和器官移植。Min博士是一名健康服务成果研究员，在链接方面具有专业知识 质量措施和质量改进与临床结果。我们的培训项目包括教师 在临床前、转化性和公共政策领域的每一位教授。除了个人 除了教师的专业知识，我们的项目还将利用密歇根大学的几个成功项目，包括： 密歇根大学老年美国人独立中心，密歇根临床和医学研究所 健康研究，衰老生物学，卫生保健政策和研究所，密歇根州生物学 心血管衰老和社会研究所。我们希望我们的新培训计划将引领 给一群训练有素的年轻内科科学家，他们将追求尖端的翻译 年龄相关疾病的研究和他们自己成为该领域的导师和领导者。

ABSTRACT The goal of this new T32 post-doctoral training grant is to train exceptional physician-scientists for independent careers in age-related conditions. We will recruit physician-scientist trainees at the completion of clinical training and before the initiation of their independent research career. Given the growing number of older adults globally, the health-related issues of older adults will dominate the health care landscape. Physician-scientists are well poised to conduct translational research relevant to the older population as they can appreciate the clinical implications of pre-clinical research and have a unique ability to identify areas of research likely to have a substantial impact on clinical care. University of Michigan (UM) is uniquely positioned to train promising physician-scientists in age-related research as UM has robust programs in geroscience/biology of aging, geriatrics, clinical medicine and health policy research. To train physician-scientists in translational medicine in age-related conditions, we will include mentors that represent the spectrum of translational medical research from preclinical research, through to research in healthy and diseased human subjects (i.e., translational), to public policy and population health. The Director (Dr. Mody) and the two Co-Directors (Drs. Goldstein and Min) of this program are all physician- scientists who examine various aspects of age-related conditions across this translational research spectrum. Dr. Mody is a clinical interventionalist who has active collaborations with investigators who conduct basic genomic research to scientists in healthcare research policy. Dr. Goldstein examines how aging impacts inflammation by employing pre-clinical models of atherosclerosis, influenza viral infection, and organ transplantation. Dr. Min is a health services outcomes researcher with expertise in linking quality measures and quality improvement with clinical outcomes. Our training program includes faculty preceptors in each of the pre-clinical, translational and public policy domains. In addition to the individual expertise of the faculty, our program also will leverage several successful programs at UM including: The University of Michigan Older Americans Independence Center, the Michigan Institute for Clinical and Health Research, Biology of Aging, Institute for Healthcare Policy and Research, Michigan Biology of Cardiovascular Aging and Institute for Social Research. We expect that our new training program will lead to a cadre of outstandingly trained young physician-scientists who will pursue cutting-edge translational research in age-related conditions and themselves become mentors and leaders in the field.