Academic leadership in the Biology of Aging and Cardiovascular Diseases

 描述(申请人提供)：心血管疾病对老年人的健康构成越来越大的威胁。然而，衰老如何影响心血管疾病仍不清楚。需要一个高度协作的环境来解开这个问题的复杂性。这一领导力奖的目标是在耶鲁医学院建立一个世界级的老龄和心血管疾病中心，以促进高生产率的研究合作，并教育和培训这一重要领域的下一代领导者。这个 拟建的中心将是美国首个此类中心，将由戈尔茨坦博士领导，戈尔茨坦博士是一位知名的内科科学家和心脏病专家，研究衰老如何影响炎症。该中心的具体目标将在以下三个目标中实现：(1)召集知名研究人员，利用临床前模型和临床材料，广泛研究随着衰老而增加的炎症如何加剧心血管疾病；(2)寻找有前途的研究员和初级教员，并在目标1的研究领域对他们进行指导，此外，向他们提供试点研究资金；以及(3)开发教育论坛(例如，关于心血管衰老相关主题的具体课程，以及年度研讨会)，以传播将基本机制转化为临床医学的关键见解。重要的是，该中心将利用耶鲁医学院的基础设施，包括胡椒中心、临床调查中心和调查医学计划。该中心的长期目标将是为多名调查员推动的提案获得外部资金，以及职业发展教员补助金和机构培训补助金，以支持博士后研究员的培训。总而言之，拟议中的中心将是耶鲁大学的一项新倡议，并将成为致力于衰老和心血管疾病研究的研究人员的杰出灯塔。

 DESCRIPTION (provided by applicant): Cardiovascular diseases are posing an increasing threat to the health of older people. However, how aging impacts cardiovascular disease remains unclear. A highly collaborative environment is required to unravel the complexities of this problem. The goal of this leadership award is to develop a world-class center on aging and cardiovascular diseases at Yale School of Medicine to foster highly productive research collaborations and to educate and train the next generation of leaders in this important field. The proposed Center would be the first of its kind in the nation and will be led by Dr. Goldstein, an established physician-scientist and cardiologist who investigates how aging impacts inflammation. The Center's specific goals will be addressed in the following three aims: (1) to bring together established investigators to broadly examine how increased inflammation with aging enhances cardiovascular diseases employing both pre-clinical models and clinical material; (2) to identify highly promising fellows and junior faculty and mentor them in research areas of Aim 1, in addition to providing them pilot research funds; and (3) to develop educational forums (e.g., a specific course on topics relevant to cardiovascular aging, and an annual symposium) to disseminate key insights that translate basic mechanisms to clinical medicine. Importantly, the Center will leverage infrastructure at the Yale School of Medicine, including the Pepper Center, Center for Clinical Investigation, and Investigative Medicine program. The long-term goals of the Center will be to obtain extramural funding for multi-investigator driven proposals as well as career development faculty grants and an institutional training grant to sustain the training of postdoctoral fellows. In summary, the proposed Center will be a new initiative for Yale and will serve as a beacon of excellence for investigators pursuing research into aging and cardiovascular diseases.