Academic leadership in the Biology of Aging and Cardiovascular Diseases

衰老和心血管疾病生物学领域的学术领导地位

• 批准号: 8869159
• 负责人: Daniel Robert Goldstein
• 金额: $ 13.01万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8869159
• 关键词: Address; Aging; Area; Award; Biological; Biological Process; Biology; Biology of Aging; Blood Vessels; Capsicum; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Clinical Medicine; Collaborations; Complex; Development; Discipline; Disease; Doctor of Philosophy; Extramural Activities; Faculty; Fostering; Funding; Goals; Grant; Health; Healthcare Systems; Immunology; Inflammation; Lead; Leadership; Link; Manuscripts; Medicine; Mentors; Physicians; Physiological; Population; Postdoctoral Fellow; Pre-Clinical Model; Qualifying; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Scientist; Societies; Surgeon; Techniques; Training; Translating; Universities; Visit; age related; career development; clinical investigation; clinical material; collaborative environment; design; experience; insight; lectures; medical schools; next generation; programs; public health relevance; success; symposium

 DESCRIPTION (provided by applicant): Cardiovascular diseases are posing an increasing threat to the health of older people. However, how aging impacts cardiovascular disease remains unclear. A highly collaborative environment is required to unravel the complexities of this problem. The goal of this leadership award is to develop a world-class center on aging and cardiovascular diseases at Yale School of Medicine to foster highly productive research collaborations and to educate and train the next generation of leaders in this important field. The proposed Center would be the first of its kind in the nation and will be led by Dr. Goldstein, an established physician-scientist and cardiologist who investigates how aging impacts inflammation. The Center's specific goals will be addressed in the following three aims: (1) to bring together established investigators to broadly examine how increased inflammation with aging enhances cardiovascular diseases employing both pre-clinical models and clinical material; (2) to identify highly promising fellows and junior faculty and mentor them in research areas of Aim 1, in addition to providing them pilot research funds; and (3) to develop educational forums (e.g., a specific course on topics relevant to cardiovascular aging, and an annual symposium) to disseminate key insights that translate basic mechanisms to clinical medicine. Importantly, the Center will leverage infrastructure at the Yale School of Medicine, including the Pepper Center, Center for Clinical Investigation, and Investigative Medicine program. The long-term goals of the Center will be to obtain extramural funding for multi-investigator driven proposals as well as career development faculty grants and an institutional training grant to sustain the training of postdoctoral fellows. In summary, the proposed Center will be a new initiative for Yale and will serve as a beacon of excellence for investigators pursuing research into aging and cardiovascular diseases.

 描述（由适用提供）：心血管疾病对老年人的健康构成越来越多的威胁。但是，衰老如何影响心血管疾病尚不清楚。需要一个高度协作的环境来揭示此问题的复杂性。该领导力奖的目的是在耶鲁大学医学院建立一个世界一流的老龄化和心血管疾病中心，以培养高度生产力的研究合作，并在这个重要领域进行教育和培训下一代领导者。这 拟建的中心将是全国第一个此类中心，并将由戈德斯坦博士（Goldstein）博士领导。该中心的具体目标将在以下三个目的中解决：（1）汇集既定的研究人员，以广泛研究使用临床前模型和临床材料的增强感染如何增强心血管疾病； （2）除了为他们提供试点研究基金外，还要在AIM 1的研究领域确定高度有希望的研究员和初级教师和男性； （3）开发教育论坛（例如，关于与心血管老化有关的主题的特定课程，以及每年的研讨会），以传播将基本机制转化为临床医学的关键见解。重要的是，该中心将利用耶鲁大学医学院的基础设施，包括胡椒中心，临床调查中心和调查医学计划。该中心的长期目标将是获得用于多投资人驱动力建议以及职业发展教师赠款的校外资金，以及一项机构培训补助金，以维持对博士后研究员的培训。总而言之，拟议中心将是耶鲁大学的一项新倡议，并将成为研究衰老和心血管疾病研究的研究人员的卓越灯塔。