Academic leadership in the Biology of Aging and Cardiovascular Diseases

衰老和心血管疾病生物学领域的学术领导地位

• 批准号: 8869159
• 负责人: Daniel Robert Goldstein
• 金额: $ 13.01万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8869159
• 关键词: Address; Aging; Area; Award; Biological; Biological Process; Biology; Biology of Aging; Blood Vessels; Capsicum; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Clinical Medicine; Collaborations; Complex; Development; Discipline; Disease; Doctor of Philosophy; Extramural Activities; Faculty; Fostering; Funding; Goals; Grant; Health; Healthcare Systems; Immunology; Inflammation; Lead; Leadership; Link; Manuscripts; Medicine; Mentors; Physicians; Physiological; Population; Postdoctoral Fellow; Pre-Clinical Model; Qualifying; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Scientist; Societies; Surgeon; Techniques; Training; Translating; Universities; Visit; age related; career development; clinical investigation; clinical material; collaborative environment; design; experience; insight; lectures; medical schools; next generation; programs; public health relevance; success; symposium

 DESCRIPTION (provided by applicant): Cardiovascular diseases are posing an increasing threat to the health of older people. However, how aging impacts cardiovascular disease remains unclear. A highly collaborative environment is required to unravel the complexities of this problem. The goal of this leadership award is to develop a world-class center on aging and cardiovascular diseases at Yale School of Medicine to foster highly productive research collaborations and to educate and train the next generation of leaders in this important field. The proposed Center would be the first of its kind in the nation and will be led by Dr. Goldstein, an established physician-scientist and cardiologist who investigates how aging impacts inflammation. The Center's specific goals will be addressed in the following three aims: (1) to bring together established investigators to broadly examine how increased inflammation with aging enhances cardiovascular diseases employing both pre-clinical models and clinical material; (2) to identify highly promising fellows and junior faculty and mentor them in research areas of Aim 1, in addition to providing them pilot research funds; and (3) to develop educational forums (e.g., a specific course on topics relevant to cardiovascular aging, and an annual symposium) to disseminate key insights that translate basic mechanisms to clinical medicine. Importantly, the Center will leverage infrastructure at the Yale School of Medicine, including the Pepper Center, Center for Clinical Investigation, and Investigative Medicine program. The long-term goals of the Center will be to obtain extramural funding for multi-investigator driven proposals as well as career development faculty grants and an institutional training grant to sustain the training of postdoctoral fellows. In summary, the proposed Center will be a new initiative for Yale and will serve as a beacon of excellence for investigators pursuing research into aging and cardiovascular diseases.

 描述（由申请人提供）：心血管疾病对老年人的健康构成越来越大的威胁。然而，衰老如何影响心血管疾病仍不清楚。需要高度协作的环境来解决这个问题的复杂性。该领导力奖的目标是在耶鲁大学医学院建立世界一流的衰老和心血管疾病中心，以促进高效的研究合作，并教育和培训这一重要领域的下一代领导者。这 拟议的中心将是美国第一个此类中心，由戈尔茨坦博士领导，他是一位著名的内科科学家和心脏病专家，研究衰老如何影响炎症。该中心的具体目标将体现在以下三个目标：（1）汇集现有研究人员，利用临床前模型和临床材料广泛研究随着衰老而增加的炎症如何增强心血管疾病； (2) 确定有前途的研究员和初级教师，并在目标 1 的研究领域对他们进行指导，并为他们提供试点研究资金； (3) 建立教育论坛（例如，关于心血管衰老相关主题的特定课程和年度研讨会），以传播将基本机制转化为临床医学的关键见解。重要的是，该中心将利用耶鲁大学医学院的基础设施，包括 Pepper 中心、临床研究中心和研究医学项目。该中心的长期目标是为多研究者推动的提案获得校外资金，以及职业发展教师补助金和机构培训补助金，以维持博士后研究员的培训。总之，拟议的中心将成为耶鲁大学的一项新举措，并将成为从事衰老和心血管疾病研究的研究人员的卓越灯塔。