Interventions to Reduce Infant Mortality and Morbidity in Low Resource Settings

降低资源匮乏地区婴儿死亡率和发病率的干预措施

• 批准号: 10426088
• 负责人: WALDEMAR A. CARLO FONT
• 金额: $ 63.34万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-03 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426088
• 关键词: Address; Alabama; Apnea; Awareness; Azithromycin; Caffeine; Caring; Cessation of life; Child; Child Health; Clinical Research; Clinical Trials; Communicable Diseases; Communities; Discipline of obstetrics; Ensure; Ethics; Focus Groups; Goals; Government; Grant; Gynecology; Health; Healthcare Systems; Hospitals; Infant Mortality; Intervention; Lead; Maternal Mortality; Membrane; Midwife; Morbidity - disease rate; Neonatal; Neonatal Mortality; Neonatology; Nursing Research; Pediatrics; Perinatal; Population; Pregnant Women; Premature Infant; Program Sustainability; Prolonged labor; Protocols documentation; Public Health; Publications; Randomized Controlled Trials; Research; Research Personnel; Resource-limited setting; Risk; Rupture; Rural; Sepsis; Site; Specialist; Teaching Hospitals; Training; Training and Education; Universities; Woman; Work; Zambia; base; design; improved; infant morbidity; low and middle-income countries; low income country; member; performance site; prophylactic; service delivery

This application provides evidence that the University of Alabama-Zambia Team has an established record of major accomplishments in the Global Network, including leading the design, implementation, and publication of single site and common protocol studies and clinical trials. For the next 5-year cycle, three rigorously-designed multicenter randomized controlled trials are proposed. The applicant and senior foreign investigator lead a research group focused on clinical trials in Zambia and other low-resource settings. This group includes obstetrics, gynecology, neonatology, general pediatrics, public health, and infectious diseases specialists as well as midwives and research nurses who have worked together for 17 years and communicate weekly. The foreign institutional support is provided by the University Teaching Hospital, a partner during the last 17 years, which fully endorses this proposal. The available population settings where our work has been conducted include the traditional Global Network rural clusters, a large tertiary hospital delivery service, and a large set of urban delivery first level facilities. The UAB-Zambia team members are well aware of the ethical and cultural issues related to the conduct of research in Zambia and low-resource settings. The special qualifications and unequivocal commitment of the Zambian investigators, as well as the full endorsement of the Government of Zambia, University Teaching Hospital (Zambia), University of Zambia, and the University of Alabama at Birmingham will ensure superior performance if this site is granted participation in the Network. The long-term objective is to improve local health care systems with education, training, implementation, and sustainability of programs to decrease neonatal and maternal mortality, with the long-term goal of reduction of morbidities.

这份申请提供了阿拉巴马大学赞比亚分校团队拥有 在全球网络中取得重大成就的既定记录，包括领导 设计、实施和发布单一站点和通用方案研究和临床 审判。在接下来的5年周期中，三个严格设计的多中心随机对照 建议进行试验。申请者和资深外国调查员领导一个研究小组 重点放在赞比亚和其他低资源环境下的临床试验。这组人包括 产科、妇科、新生儿科、普通儿科、公共卫生和传染病 在一起工作了17年的专家以及助产士和研究护士 每周交流一次。外国机构的支持由该大学提供 教学医院，过去17年的合作伙伴，它完全支持这一建议。这个 我们开展工作的可用人口环境包括传统的全球 网络农村集群、大型三级医院接生服务和大型城市接生 一流的设施。UAB-赞比亚团队成员非常了解道德和文化 与在赞比亚和低资源环境下进行研究有关的问题。特价商品 赞比亚调查人员的资格和明确承诺，以及 赞比亚政府、大学教学医院(赞比亚)、大学 如果这样的话，阿拉巴马大学伯明翰分校将确保卓越的表现 网站被授予加入该网络的资格。长期目标是改善当地的健康状况 护理系统，包括教育、培训、实施和方案的可持续性 降低新生儿和产妇死亡率，长期目标是减少发病率。