Interventions to Reduce Infant Mortality and Morbidity in Low Resource Settings

项目摘要 本申请提供的证据表明，主要和国际主要研究者 领导UAB-赞比亚团队在以下方面取得了重大成就 全球网络，包括设计、实施和出版单一网站， 共同协议临床试验和研究，导致主要的国际和国家指南 改善护理实践。UAB-赞比亚团队可以获得一套稳定的 地理上不同的农村集群和城市交付设施， 过去19年的研究。国际合作伙伴，大学教学 赞比亚医院/大学，以及一个多学科小组， 赞比亚卢萨卡的产科、儿科和公共卫生部门合作开展研究， 培训、教育和实施/扩大针对妇女的最新研究 产妇和新生儿/婴儿/儿童死亡和严重发病的最常见原因。 卓越的组织能力和当地的支持有助于充分参与所有 全球网络试验和研究，包括高招募率和超过99%的随访率。的 UAB和赞比亚的行政团队为所有项目的成功提供一切必要的支持， 赠款活动。所有赞比亚工作人员都有出色的业绩记录， 在网络中取得的成就，包括自第一个周期以来与团队合作的大部分工作， 全球网络。拟议的调查小组已经合作了19年以上 并将继续与NICHD和全球网络的其他站点合作， 创新和有影响力的随机试验和观察性研究， 母亲和婴儿。UAB-赞比亚团队设计了重大的变革性研究 包括FIRST BREATH、BRAIN-HIT和A-PLUS试验以及预测建模 资源有限地区围产期死亡率数据库研究。的资格和 调查人员和赞比亚工作人员的明确承诺， 赞比亚政府、大学教学医院（赞比亚）、赞比亚大学， 亚拉巴马大学伯明翰分校将确保上级性能，如果这个网站被授予 参与网络。长期目标是改善地方卫生保健系统 随着教育、培训、研究、实施和项目的可持续性， 可预防的孕产妇和儿童死亡率和发病率。

Project Summary This application provides evidence that the Principal and International Principal Investigators leading the UAB-Zambia team have an established record of major accomplishments in the Global Network, including the design, implementation, and publication of single site and common protocol clinical trials and studies that led to major international and national guidelines and improved care practices. The UAB-Zambia team has access to a stable set of geographically distinct rural clusters and urban delivery facilities where the team has conducted research over the last 19 years. The international partner, University Teaching Hospital/University of Zambia, and a multi-disciplinary team consisting of specialists in obstetrics, pediatrics, and public health in Lusaka, Zambia have collaborated in research, training, education, and implementation/scale-up of state-of-the-art research targeted to the most common causes of maternal and neonatal/infant/child mortality and severe morbidities. The exceptional organizational capabilities and local support facilitate full participation in all Global Network trials and studies, including high recruitment and over 99% follow-up rates. The administrative teams at UAB and Zambia provide all the necessary support for the success of all grant activities. All Zambian staff members have a record of excellent performance and accomplishments in the Network, including most working with the team since the first cycle of the Global Network. The proposed team of investigators have collaborated for over 19 years and will continue to work with the NICHD and other sites of the Global Network to lead innovative and impactful randomized trials and observational studies that transform the care of mothers and infants. The UAB-Zambia team has designed major transformative studies including the FIRST BREATH, BRAIN-HIT, and A-PLUS trials as well as the Predictive Modeling for Perinatal Mortality in Resource-Limited Settings database study. The qualifications and unequivocal commitment of the investigators the Zambian staff, as well as the full endorsement of the Government of Zambia, University Teaching Hospital (Zambia), University of Zambia, and the University of Alabama at Birmingham will ensure superior performance if this site is granted participation in the Network. The long-term objective is to improve local health care systems with education, training, research, implementation, and sustainability of programs to decrease preventable maternal and child mortality and morbidities.