Interventions to Reduce Infant Mortality and Morbidity in Low Resource Settings

这份申请提供了证据，证明赞比亚大学队有一个 在全球网络中取得重大成就的既定记录，包括领导 设计、实施和发表单中心和通用方案研究以及临床 审判在接下来的5年周期中，三个严格设计的多中心随机对照研究 审判被提议。申请人和外国高级研究员领导一个研究小组 专注于在赞比亚和其他低资源环境中的临床试验。这一组包括 产科、妇科、泌尿科、普通儿科、公共卫生和传染病 专家以及助产士和研究护士谁一起工作了17年 每周沟通。国外机构支持由大学提供 教学医院，在过去17年的合作伙伴，它完全赞同这一建议。的 我们开展工作的现有人口环境包括传统的全球 网络农村集群，大型三级医院交付服务，以及大型城市交付 一级设施。UAB-赞比亚团队成员非常了解 与在赞比亚和低资源环境下开展研究有关的问题。特别 赞比亚调查人员的资格和明确承诺， 赞比亚政府、大学教学医院（赞比亚）、大学 赞比亚大学和伯明翰的亚拉巴马大学将确保上级性能， 网站被授予参与网络。长期目标是改善当地的健康状况 护理系统与教育，培训，实施和可持续性的方案， 降低新生儿和产妇死亡率，长期目标是降低发病率。

This application provides evidence that the University of Alabama-Zambia Team has an established record of major accomplishments in the Global Network, including leading the design, implementation, and publication of single site and common protocol studies and clinical trials. For the next 5-year cycle, three rigorously-designed multicenter randomized controlled trials are proposed. The applicant and senior foreign investigator lead a research group focused on clinical trials in Zambia and other low-resource settings. This group includes obstetrics, gynecology, neonatology, general pediatrics, public health, and infectious diseases specialists as well as midwives and research nurses who have worked together for 17 years and communicate weekly. The foreign institutional support is provided by the University Teaching Hospital, a partner during the last 17 years, which fully endorses this proposal. The available population settings where our work has been conducted include the traditional Global Network rural clusters, a large tertiary hospital delivery service, and a large set of urban delivery first level facilities. The UAB-Zambia team members are well aware of the ethical and cultural issues related to the conduct of research in Zambia and low-resource settings. The special qualifications and unequivocal commitment of the Zambian investigators, as well as the full endorsement of the Government of Zambia, University Teaching Hospital (Zambia), University of Zambia, and the University of Alabama at Birmingham will ensure superior performance if this site is granted participation in the Network. The long-term objective is to improve local health care systems with education, training, implementation, and sustainability of programs to decrease neonatal and maternal mortality, with the long-term goal of reduction of morbidities.