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Heart Rate Detection during Resuucitation to Reduce Early Neonatal Mortality

复苏期间的心率检测可降低新生儿早期死亡率

基本信息

批准号：
8658453
负责人：
WALDEMAR A. CARLO FONT
金额：
$ 65.83万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-05-03 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8658453
关键词：
Academy Accounting Address Affect Age Age-Months Alabama American Appointment Asphyxia Autopsy Awareness Birth Birth Weight Breathing Cerebral Palsy Cessation of life Child Child health care Clinical Trials Clinical assessments Communities Country Crying Data Databases Detection Developing Countries Development Disabled Persons Disease Effectiveness Electronics Ensure Goals Government Grant Health Healthcare Systems Heart Rate Infant Intervention Life Low Birth Weight Infant Low income Maternal Mortality Measures Midwife Morbidity - disease rate Mothers National Institute of Child Health and Human Development Neonatal Neonatal Mortality Neurologic Newborn Infant Observational Study Outcome Pediatrics Periderm Physicians Pregnant Women Premature Infant Principal Investigator Program Sustainability Protocols documentation Publications Randomized Controlled Clinical Trials Relative Risks Reporting Research Research Personnel Resuscitation Risk Site Subgroup Teaching Hospitals Techniques Testing Training Training and Education Universities Woman Work Zambia adverse outcome base cost data registry design detector evidence base handicapping condition improved infant morbidity/mortality innovation intrapartum meetings member mortality neonatal death neonatal morbidity neonatal resuscitation neonate performance site prenatal prevent primary care setting public health relevance randomized trial skills socioeconomics stillbirth

项目摘要

DESCRIPTION (provided by applicant): This application provides evidence that the Principal and Senior Foreign Investigators have an established record of major accomplishments in the Global Network including the design, implementation, and publication of single site and common protocol studies and clinical trials. For the next 5 year cycle, a rigorously-designed multicenter cluster randomized controlled clinical trial of the innovative use of a low cost and simple heart rate detector to guide neonatal resuscitation in primary care settings in low-income countries using the standard American Academy of Pediatrics Helping Babies Breathe protocol is proposed to determine its effectiveness in reducing early (7-day) neonatal mortality. The heart rate detector will assist birth attendants to determine the heart rate. Five to 10 percent of newborn infants appear lifeless at birth without breathing or crying, and determination of the heart rate and other signs of life is difficult for the birth attendants. For infants born alive, a increasing heart rate is the best indicator of an effective resuscitation. Assessment of heart rate changes is difficult to periderm with the usual clinical assessments in the field, and thus many infants die soon after birth. Neonatal resuscitation skills can be guided by heart rate detection even if a feeble heart rate is detected. If effective, electronic heart rate detection may be a breakthrough for deliveries by low- and middle-skilled birth attendants. The proposed team of investigators has collaborated for over 10 years and will continue to work with the NICHD and other sites of the Global Network to design, implement, analyze, and report innovative randomized trials and observational studies that are likely to reduce mortality and morbidities of mothers and infants. The qualifications and unequivocal commitment of the investigators the Zambian staff, as well as the full endorsement of the Government of Zambia, University Teaching Hospital (Zambia), University of Zambia, and the University of Alabama at Birmingham will ensure superior performance if this site is granted participation in the Network. The long-term objective is to improve local health care systems with education, training, implementation, and sustainability of programs to decrease neonatal mortality with the goal of long-term reduction in mortality and morbidity of infants.

描述（由申请人提供）：该申请提供证据，证明首席和高级外国研究员在全球网络中有主要成就的既定记录，包括设计、实施和发表单站点和通用方案研究和临床试验。在接下来的5年周期中，提出了一项严格设计的多中心随机对照临床试验，该试验旨在创新使用低成本和简单的心率检测器来指导低收入国家初级保健机构使用标准的美国儿科学会帮助婴儿呼吸协议的新生儿复苏，以确定其在降低早期（7天）新生儿死亡率方面的有效性。心率检测器将帮助助产士确定心率。5%到10%的新生儿在出生时没有呼吸或哭泣，而且对助产士来说，很难确定心率和其他生命迹象。对于活着出生的婴儿，心率加快是有效复苏的最佳指标。心率评估