Bruker D8 VENTURE Diffractometer

布鲁克 D8 VENTURE 衍射仪

• 批准号: 10429832
• 负责人: Bo Li
• 金额: $ 42.83万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10429832
• 关键词: 12 year old; Age; Area; Biochemistry; Biology; Boston; Charge; Chemicals; Consumption; Coupled; Crystallization; Data; Data Collection; Faculty; Funding; Light; Measurement; Methods; Modeling; Organic Chemistry; Production; Radiation; Research; Research Activity; Roentgen Rays; Sampling; Services; Source; Structure; Temperature; Time; United States National Institutes of Health; Work; X-Ray Crystallography; bioactive natural products; college; density; detector; drug candidate; experimental study; improved; instrument; member; programs; quantum; small molecule; tool

Project Summary/Abstract The Center for X-ray Crystallography at Boston College is seeking funds to purchase a Bruker D8 VENTURE Diffractometer coupled with duo ImuS radiation sources (Mo and Cu) and a PHOTON III detector for small molecule structural characterization. Currently the only single-crystal X-ray diffractometer at Boston College is an 12-year old Bruker APEX II DUO diffractometer purchased in 2009. This essential workhorse instrument has become unreliable with age and heavy usage. Due to discontinuation of production of this model instrument and a lack of replacement parts, Bruker will end service support for our current instrument starting June 1, 2021. The Bruker D8 VENTURE allows users to collect high-quality charge density data with Mo radiation and to exploit all the advantages of the Cu wavelength for absolute structure determinations and diffraction experiments on small organic crystals. This new instrument will provide indispensable analytical support for a very broad range of research programs from eight faculty members, among them, seven are NIH-supported. Research activities are concentrated primarily in the areas of synthetic organic chemistry, and biochemistry/chemical biology, targeted to develop methods for the synthesis of bioactive natural products, small molecule drug candidates, and macromolecular biomolecules. Such projects depend highly on the acquisition of structural information of intermediate and end products. X-ray crystallography is an indispensable tool for this work, and in many cases, the only reliable method to obtain structural information. The combination of ultra brightness of the ImuS sources, with the quantum-limited sensitivity of the PHOTON III detector, will not only greatly improve our capability on small and weakly-diffracted samples, but also fulfil the steadily rising needs for absolute configuration determinations on molecules that only contain light atoms. Users are more likely to get crystal structures from samples that were previously found to be unsuitable or too small. Time consuming experiments such as variable temperature measurements will become more practical and data collection on metastable crystals will be amenable, thanks to faster acquisition time.

项目总结/摘要 波士顿学院X射线晶体学中心正在寻求资金购买布鲁克D8 Venture 衍射仪与双伊穆斯辐射源（Mo和Cu）和PHOTON III检测器耦合，用于小 分子结构表征。目前波士顿学院唯一的单晶X射线衍射仪是 2009年购买的有12年历史的布鲁克APEX II DUO衍射仪。这台重要的主力仪器 随着年龄的增长和大量使用而变得不可靠。由于停止生产这一示范文书， 由于缺少更换部件，布鲁克将从2021年6月1日起终止对我们现有仪器的服务支持。 布鲁克D8 VENTURE允许用户使用Mo辐射收集高质量的电荷密度数据， 铜波长的绝对结构测定和衍射实验的所有优点， 小的有机晶体这一新仪器将为一系列非常广泛的 八名教师的研究项目中，有七个是NIH支持的。研究活动 主要集中在合成有机化学和生物化学/化学生物学领域， 有针对性地开发用于合成生物活性天然产物，小分子候选药物， 和大分子生物分子。这类项目在很大程度上取决于获取的结构信息， 中间产品和最终产品。X射线晶体学是这项工作不可或缺的工具，在许多情况下， 这是获取结构信息的唯一可靠方法。伊穆斯光源的超高亮度， 与光子III探测器的量子极限灵敏度，不仅将大大提高我们的能力， 小而弱衍射的样品，而且还满足了对绝对配置的不断增长的需求 对只含有轻原子的分子的测定。使用者更有可能从 以前发现不合适或太小的样品。耗时的实验，如变量 温度测量将变得更加实用，亚稳晶体的数据收集将 这要归功于更快的收购时间。