Bruker D8 VENTURE Diffractometer

项目摘要/摘要 波士顿学院X射线结晶学中心正在寻求资金，以收购布鲁克D8公司 与双IMUS辐射源(钼和铜)和光子III探测器相耦合的小型衍射仪 分子结构表征。目前波士顿学院唯一的单晶X射线衍射仪是 2009年购买的布鲁克APEX II双衍射仪，已有12年的历史。这种重要的主力乐器有 随着年龄的增长和过度使用而变得不可靠。由于该模型仪器的停产和 由于缺乏更换部件，布鲁克将从2021年6月1日起终止对我们当前仪器的服务支持。 Bruker D8合资企业允许用户收集具有钼辐射的高质量电荷密度数据，并利用 铜波长在绝对结构测定和衍射实验中的所有优势 小的有机晶体。这一新仪器将为非常广泛的范围提供不可或缺的分析支持。 在8名教职员工的研究项目中，有7个得到了NIH的支持。研究活动 主要集中在合成有机化学和生物化学/化学生物学领域， 有针对性地开发合成具有生物活性的天然产物、小分子候选药物、 和大分子生物分子。这类项目高度依赖于获取结构信息 中间产品和最终产品。X射线结晶学是这项工作不可或缺的工具，在许多情况下， 获取结构信息的唯一可靠方法。结合IMUS光源的超高亮度， 凭借光子III探测器的量子有限灵敏度，不仅将极大地提高我们在 小样品和弱衍射样品，但也满足稳步上升的绝对组态的需求 对只含有轻原子的分子的测定。用户更有可能从以下位置获得晶体结构 以前被发现不适合或太小的样本。耗时的实验，如变量 温度测量将变得更加实用，亚稳态晶体的数据收集将 服从，这要归功于更快的收购时间。

Project Summary/Abstract The Center for X-ray Crystallography at Boston College is seeking funds to purchase a Bruker D8 VENTURE Diffractometer coupled with duo ImuS radiation sources (Mo and Cu) and a PHOTON III detector for small molecule structural characterization. Currently the only single-crystal X-ray diffractometer at Boston College is an 12-year old Bruker APEX II DUO diffractometer purchased in 2009. This essential workhorse instrument has become unreliable with age and heavy usage. Due to discontinuation of production of this model instrument and a lack of replacement parts, Bruker will end service support for our current instrument starting June 1, 2021. The Bruker D8 VENTURE allows users to collect high-quality charge density data with Mo radiation and to exploit all the advantages of the Cu wavelength for absolute structure determinations and diffraction experiments on small organic crystals. This new instrument will provide indispensable analytical support for a very broad range of research programs from eight faculty members, among them, seven are NIH-supported. Research activities are concentrated primarily in the areas of synthetic organic chemistry, and biochemistry/chemical biology, targeted to develop methods for the synthesis of bioactive natural products, small molecule drug candidates, and macromolecular biomolecules. Such projects depend highly on the acquisition of structural information of intermediate and end products. X-ray crystallography is an indispensable tool for this work, and in many cases, the only reliable method to obtain structural information. The combination of ultra brightness of the ImuS sources, with the quantum-limited sensitivity of the PHOTON III detector, will not only greatly improve our capability on small and weakly-diffracted samples, but also fulfil the steadily rising needs for absolute configuration determinations on molecules that only contain light atoms. Users are more likely to get crystal structures from samples that were previously found to be unsuitable or too small. Time consuming experiments such as variable temperature measurements will become more practical and data collection on metastable crystals will be amenable, thanks to faster acquisition time.