Mentoring in Discovery and Validation of Clinical Chronic Pain Biomarkers

这个K24应用程序的主要目标是让肖恩麦基，医学博士，博士，建立和扩大他的高- 在以患者为导向的研究（POR）中，对早期职业研究者的质量和密集指导。麦基博士是 斯坦福大学疼痛医学系主任兼雷德利希教授。K24提供了博士。 Mackey在POR和指导方面的关键保护时间，否则将用于行政管理 临床责任。 Mackey博士的K24应用指导计划建立在他目前资助的HEAL项目的基础上，该项目名为： 高影响慢性疼痛的诊断和预后生物标志物：开发和验证。慢性疼痛 这场公共卫生危机影响了1亿多美国人，耗资超过5000亿美元。 每年。据估计，8%的美国成年人患有高影响慢性疼痛，或与疼痛相关的疼痛。 严重限制工作、社交和自我照顾活动达六个月或以上。个人的亚群体 完全缓解，不改变，甚至在疼痛管理后恶化。因此，稳健且经过验证 需要诊断和预后生物标志物来识别那些具有高影响力的慢性疼痛的患者， 结果的轨迹（即，恢复与持久性）。因此，我们的总体目标是， 发现和验证肌肉骨骼高影响慢性疼痛的诊断和预后生物标志物。这 这一目标将需要全面、多层面的评估，包括综合数据集和复杂的 计算分析管道，以产生可靠和验证的诊断和预后生物标志物。本 最后，我们组建了一个跨学科的研究和临床团队来实施HEAL计划。 麦基博士的指导计划包括培训他的学员：1）设计和实施疼痛研究 研究; 2）准备科学论文和演示文稿; 3）撰写成功的资助申请; 4） 负责任的研究行为;和5）学术过程的成功导航，以实现科学 独立这一指导计划将适用于他指导的K受助者和他作为 NIDA T32“疼痛和药物使用障碍跨学科研究培训”项目总监。 学员将以三种方式参与培训活动。第一种是通过直接参与 R61/R33生物标志物项目，通过参与研究项目的各个方面。二是通过 研讨会，期刊俱乐部，会议和课程，扩展了我们的T32培训计划，重点是这一点 HEAL生物标志物项目。第三种是通过学员主导的试点项目，利用母项目 资源和相关的多学科基础设施。受资助的HEAL项目，结合 K24提供的额外辅导时间将提供出色的POR培训和辅导 为我们现有和未来的K获奖者，T32研究员和其他学员提供平台-并促进 他们转变为独立的以病人为导向的疼痛研究者。

The primary goal of this K24 application is to allow Sean Mackey, M.D., Ph.D., to build and expand on his high- quality and intensive mentorship of early-career investigators in patient-oriented research (POR). Dr. Mackey is the Redlich Professor and Chief, Division of Pain Medicine at Stanford University. This K24 provides Dr. Mackey with the critical protected time for POR and mentoring that would otherwise be spent on administrative and clinical responsibilities. Dr. Mackey's mentoring plan for this K24 application builds on his currently funded HEAL project entitled: “Diagnostic and prognostic biomarkers for high-impact chronic pain: Development and validation”. Chronic pain represents a public health crisis that affects more than 100 million Americans and costs over $500 billion annually. An estimated 8% of US adults suffer from high-impact chronic pain, or pain associated with substantially restricted work, social, and self-care activities for six or more months. Subgroups of individuals respond entirely, do not change, or even worsen following pain management. Thus, robust and validated diagnostic and prognostic biomarkers are needed to identify those with high-impact chronic pain and determine the trajectory of outcome (i.e., recovery versus persistence), respectively. Therefore, our overall goal is to discover and validate diagnostic and prognostic biomarkers for musculoskeletal high-impact chronic pain. This goal will require comprehensive, multidimensional assessments with an integrated dataset and a sophisticated computational analysis pipeline to yield reliable and validated diagnostic and prognostic biomarkers. To this end, we have assembled an interdisciplinary research and clinical team to implement the HEAL initiative. Dr. Mackey's mentoring plan includes training his mentees in: 1) designing and implementing pain research studies; 2) preparing scientific papers and presentations; 3) writing successful grant applications; 4) the responsible conduct of research; and 5) successful navigation of the academic process to achieve scientific independence. This mentoring plan will be applied to the K grantees he mentors and those he oversees as the Program Director for his NIDA T32 “Interdisciplinary Research Training in Pain and Substance Use Disorders.” The mentees will engage in the training activites in three manners. The first is through direct involvement in the parent R61/R33 biomarker project via participation in aspects of the research project. The second is through seminars, journal clubs, meetings, and coursework that expands on our T32 Training Program focusing on this HEAL biomarker project. The third is through trainee-led pilot projects that leverage the parent project resources and associated multidisciplinary infrastructure. The funded HEAL project, combined with the additional mentoring time provided by the K24, will provide an exceptional POR training and mentoring platform for our large group of current and future K awardees, T32 fellows, and other trainees – and facilitate their transition into independent patient-oriented pain researchers.