Mentoring in Discovery and Validation of Clinical Chronic Pain Biomarkers
Mentoring in Discovery and Validation of Clinical Chronic Pain Biomarkers
批准号:
10429456
负责人:
SEAN C MACKEY
金额:
$32.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-24 至 2024-08-31
关键词:
AccelerometerAdultAffectAmericanAnxietyApplications GrantsBiologicalBiological MarkersChronicClinicalComputer AnalysisDataData CollectionData SetDemographic FactorsDevelopmentDiagnosticDoctor of MedicineDoctor of PhilosophyEnrollmentFunctional disorderFundingFutureGoalsHelping to End Addiction Long-termImmuneIndividualInfrastructureInterdisciplinary StudyJournalsMachine LearningMedicineMentorsMentorshipMid-Career Clinical Scientist Award (K24)MusculoskeletalNational Institute of Drug AbuseNeuraxisOutcomePainPain ResearchPain interferencePain managementPaperParentsPatientsPhasePhysiciansPilot ProjectsPreventive treatmentProcessPrognostic MarkerPsychologyPublic HealthPublicationsPublishingRecoveryRefractoryResearchResearch PersonnelResearch Project GrantsResearch TrainingResourcesRiskSelf CareSensorySeveritiesSleepSocial isolationSocietiesStructureSubgroupSubstance Use DisorderTimeTrainingTraining ActivityTraining ProgramsUnited States National Institutes of HealthUniversitiesValidationWorkWritingactigraphyanalysis pipelinebasebiomarker signaturecandidate markercareercareer developmentchronic musculoskeletal painchronic paincohortconditioned pain modulationcostdesigndiagnostic biomarkerindividualized medicinelarge datasetsmachine learning algorithmmeetingsmicrobiomemultidisciplinarymultiple omicsneuroimagingnew therapeutic targetnovel markerparent projectpatient orientedpatient oriented researchprofessorprognosticprognostic signatureprogramspsychosocialresearch and developmentresearch studyresponsible research conductrisk stratificationsocialtreatment strategytreatment stratification
中文摘要
这个K24应用程序的主要目标是允许肖恩麦基,医学博士,博士,建立和扩大他的高
英文摘要
The primary goal of this K24 application is to allow Sean Mackey, M.D., Ph.D., to build and expand on his high-
quality and intensive mentorship of early-career investigators in patient-oriented research (POR). Dr. Mackey is
the Redlich Professor and Chief, Division of Pain Medicine at Stanford University. This K24 provides Dr.
Mackey with the critical protected time for POR and mentoring that would otherwise be spent on administrative
and clinical responsibilities.
Dr. Mackey's mentoring plan for this K24 application builds on his currently funded HEAL project entitled:
“Diagnostic and prognostic biomarkers for high-impact chronic pain: Development and validation”. Chronic pain
represents a public health crisis that affects more than 100 million Americans and costs over $500 billion
annually. An estimated 8% of US adults suffer from high-impact chronic pain, or pain associated with
substantially restricted work, social, and self-care activities for six or more months. Subgroups of individuals
respond entirely, do not change, or even worsen following pain management. Thus, robust and validated
diagnostic and prognostic biomarkers are needed to identify those with high-impact chronic pain and determine
the trajectory of outcome (i.e., recovery versus persistence), respectively. Therefore, our overall goal is to
discover and validate diagnostic and prognostic biomarkers for musculoskeletal high-impact chronic pain. This
goal will require comprehensive, multidimensional assessments with an integrated dataset and a sophisticated
computational analysis pipeline to yield reliable and validated diagnostic and prognostic biomarkers. To this
end, we have assembled an interdisciplinary research and clinical team to implement the HEAL initiative.
Dr. Mackey's mentoring plan includes training his mentees in: 1) designing and implementing pain research
studies; 2) preparing scientific papers and presentations; 3) writing successful grant applications; 4) the
responsible conduct of research; and 5) successful navigation of the academic process to achieve scientific
independence. This mentoring plan will be applied to the K grantees he mentors and those he oversees as the
Program Director for his NIDA T32 “Interdisciplinary Research Training in Pain and Substance Use Disorders.”
The mentees will engage in the training activites in three manners. The first is through direct involvement in the
parent R61/R33 biomarker project via participation in aspects of the research project. The second is through
seminars, journal clubs, meetings, and coursework that expands on our T32 Training Program focusing on this
HEAL biomarker project. The third is through trainee-led pilot projects that leverage the parent project
resources and associated multidisciplinary infrastructure. The funded HEAL project, combined with the
additional mentoring time provided by the K24, will provide an exceptional POR training and mentoring
platform for our large group of current and future K awardees, T32 fellows, and other trainees – and facilitate
their transition into independent patient-oriented pain researchers.
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DOI:
10.1371/journal.pcbi.1010496
发表时间:
2022-10
期刊:
PLoS computational biology
影响因子:
4.3
作者:
[]
通讯作者:
DOI:
10.1038/s41598-022-10431-5
发表时间:
2022-04-19
期刊:
SCIENTIFIC REPORTS
影响因子:
4.6
作者:
[Ziadni, Maisa S., You, Dokyoung S., Cramer, Eric M., Anderson, Steven R., Hettie, Gabrielle, Darnall, Beth D., Mackey, Sean C.]
通讯作者:
Mackey, Sean C.
DOI:
10.3389/fpain.2022.850713
发表时间:
2022
期刊:
Frontiers in pain research (Lausanne, Switzerland)
影响因子:
--
作者:
[]
通讯作者:
Utilizing a learning health system to capture real-world patient data: Application of the reliable change index to evaluate and improve the outcome of a pain rehabilitation program.
利用学习健康系统捕获真实世界的患者数据:应用可靠的变化指数来评估和改善疼痛康复计划的结果。
DOI:
10.1111/papr.13364
发表时间:
2024
期刊:
Pain practice : the official journal of World Institute of Pain
影响因子:
--
作者:
[You,DokyoungS, Chong,JeanetteL, Mackey,SeanC, Poupore-King,Heather]
通讯作者:
Poupore-King,Heather
DOI:
10.1038/s41598-022-16835-7
发表时间:
2022-07-25
期刊:
SCIENTIFIC REPORTS
影响因子:
4.6
作者:
[Park, Su Hyoun, Baker, Anne K., Krishna, Vinit, Mackey, Sean C., Martucci, Katherine T.]
通讯作者:
Martucci, Katherine T.
Prognostic biomarkers for high-impact chronic pain: Development and validation
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批准号:10157953
-
项目类别:
-
资助金额:$725.54万
-
财政年份:2020
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:9395540
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2016
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:8475045
-
项目类别:
-
资助金额:$35.71万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and/or Substance Use Disorders
-
批准号:10398886
-
项目类别:
-
资助金额:$54.38万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:9068472
-
项目类别:
-
资助金额:$0.54万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:8874185
-
项目类别:
-
资助金额:$44.8万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:8654329
-
项目类别:
-
资助金额:$36.21万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:8879318
-
项目类别:
-
资助金额:$10.77万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Interdisciplinary Research Training in Pain and Substance Use Disorders
-
批准号:9282703
-
项目类别:
-
资助金额:$43.54万
-
财政年份:2013
-
负责人:SEAN C MACKEY
-
依托单位:
Administrative Core/S.Mackey
-
批准号:8138741
-
项目类别:
-
资助金额:$13.14万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Neural Mechanisms Underlying MBSR and CBT in Patients/J.Gross
-
批准号:8138737
-
项目类别:
-
资助金额:$29.37万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Control of Brain Activity and Chronic Back Pain via Real Time/S.Mackey
-
批准号:8138735
-
项目类别:
-
资助金额:$43.16万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Central Mechanisms of Acupuncture in the Treatment of Chronic /R.Manber/J.Kong
-
批准号:8138739
-
项目类别:
-
资助金额:$12.79万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Stanford CAM Center for Chronic Back Pain
-
批准号:8327503
-
项目类别:
-
资助金额:$44.99万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Stanford CAM Center for Chronic Back Pain
-
批准号:8326629
-
项目类别:
-
资助金额:$178.2万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
FUNCTIONAL CONNECTIVITY IN PATIENTS WITH CHRONIC NEUROPATHIC PAIN
-
批准号:8362903
-
项目类别:
-
资助金额:$1.3万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Stanford CAM Center for Chronic Back Pain
-
批准号:8934634
-
项目类别:
-
资助金额:$9.51万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Stanford CAM Center for Chronic Back Pain
-
批准号:8130340
-
项目类别:
-
资助金额:$180.0万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Stanford CAM Center for Chronic Back Pain
-
批准号:8605788
-
项目类别:
-
资助金额:$9.96万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
Stanford CAM Center for Chronic Back Pain
-
批准号:8496503
-
项目类别:
-
资助金额:$193.74万
-
财政年份:2011
-
负责人:SEAN C MACKEY
-
依托单位:
海外基金