Interdisciplinary Research Training in Pain and/or Substance Use Disorders

疼痛和/或药物使用障碍的跨学科研究培训

• 批准号: 10398886
• 负责人: SEAN C MACKEY
• 金额: $ 54.38万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398886
• 关键词: Interdisciplinary Study; Pain; Research Training; Substance Use Disorder

Project Summary/Abstract: This competing application seeks an additional five years (Years 6-10) of support for a post-doctoral research training program in pain and substance use disorders. The magnitude of these two problems in the US is astounding. More than 100 million Americans have pain that persists for weeks to years and over 20 million meet diagnostic criteria for an alcohol/drug use disorder. According to the National Academy of Medicine’s (NAM) report, Relieving Pain in America and the Surgeon General’s report Facing Addiction, these problems cost society almost $1 trillion annually. Contemporary neurobiologic, psychological, and epidemiologic research as well as the tragic experience of the opioid addiction epidemic show a clear intersection of pain and SUDs. Two of the NAM committee’s recommendations for improving research at a national level are (1) increase support for interdisciplinary research in pain, and (2) increase the training of pain researchers. Similarly, NIDA’s strategic goals and the Surgeon General’s report call for the multidisciplinary training of scientists to address the complexities of SUD research. In this proposal, we describe a collaborative, postdoctoral (PhD, MD/PhD and MD), interdisciplinary training program that will produce scientists with rigorous grounding in pain and SUD research. The accomplished faculty are all committed to interdisciplinary collaboration and mentorship across their substantive areas of expertise, which range from cells-to-society. The training program includes both required and elective coursework, mentored research experiences, an individual integrated research project, seminars, and exposure to professional development skills, including grant proposal and manuscript writing. The training program housed in the Division of Pain Medicine, Department of Anesthesiology, Stanford University School of Medicine, is intended to develop postdoctoral trainees’ skills, so that they will become independent investigators in the fields of pain, SUD and their intersection. The training program will be led by Dr. Sean Mackey, in collaboration with a steering committee comprising senior scientist/mentors. They will oversee the training, scientific, and administrative aspects of the program, including a rigorous process of internal and external evaluation. In summary, this training program will bring together a talented group of post-doctoral trainees, an accomplished team of interdisciplinary mentors, an effective administrative structure, and a world- class research environment at Stanford University. The combination of talent and environment will launch the next generation of researchers who will advance our scientific knowledge and practice of pain and substance use disorders.

项目摘要/摘要： 这项相互竞争的申请为博士后研究寻求额外五年(6-10年)的支持 关于疼痛和物质使用障碍的培训计划。这两个问题在美国的严重程度是 令人震惊。超过1亿美国人的疼痛持续数周到数年，超过2000万人 符合酒精/药物使用障碍的诊断标准。根据美国国家医学科学院的 (NAM)报告，在美国缓解疼痛和卫生局局长的报告面临成瘾，这些问题 每年给社会造成近1万亿美元的损失。当代神经生物学、心理学和流行病学 阿片成瘾流行的研究和悲惨经历表明，痛苦和 肥皂水。不结盟运动委员会关于在国家一级改进研究的两项建议是(1) 增加对疼痛跨学科研究的支持，以及(2)增加对疼痛研究人员的培训。 同样，NIDA的战略目标和卫生局局长的报告呼吁对 科学家们致力于解决SUD研究的复杂性。 在这项建议中，我们描述了一种协作的、博士后(博士、医学博士/博士和医学博士)、跨学科培训 该计划将培养出在疼痛和苏氏研究方面有严格基础的科学家。成功者 所有教员都致力于跨学科协作和在他们的实质性领域提供指导 专业知识，从细胞到社会。培训计划包括必修课和选修课 课程作业、指导研究经验、个人综合研究项目、研讨会和 接触专业发展技能，包括拨款申请和手稿写作。培训 计划设在斯坦福大学麻醉学系疼痛医学部 医学，旨在培养博士后实习生的技能，使他们成为独立的人 疼痛领域的研究人员，SUD及其交叉点。培训计划将由肖恩博士领导 麦基与一个由资深科学家/导师组成的指导委员会合作。他们将监督 计划的培训、科学和管理方面，包括严格的内部和 外部评估。总之，这一培训计划将汇聚一批博士后人才 学员，一支经验丰富的跨学科导师团队，有效的管理结构，以及一个世界- 斯坦福大学的班级研究环境。人才和环境的结合将推出 下一代研究人员将推动我们对疼痛和物质的科学知识和实践 使用障碍。

项目成果

A thalamic input to the nucleus accumbens mediates opiate dependence.

• DOI: 10.1038/nature16954
• 发表时间: 2016-02-11
• 期刊: Nature
• 影响因子: 64.8
• 作者: Zhu Y;Wienecke CF;Nachtrab G;Chen X
• 通讯作者: Chen X

Availability of Extended-Release Buprenorphine to Treat Opioid Use Disorders Among Medicaid-Covered Patients.

• DOI: 10.1176/appi.ps.202000165
• 发表时间: 2021-02-01
• 期刊: Psychiatric services (Washington, D.C.)
• 作者: Shover CL

Voluntary Opioid Tapering-Reply.

自愿阿片类药物逐渐减少-回复。

• DOI: 10.1001/jamainternmed.2018.2112
• 发表时间: 2018
• 期刊: JAMA internal medicine
• 影响因子: 39
• 作者: Darnall,BethD;Ziadni,MaisaS;Stieg,RichardL
• 通讯作者: Stieg,RichardL

Coping motives mediate the relationship between borderline personality features and alcohol, cannabis, and prescription opioid use disorder symptomatology in a substance use disorder treatment sample.

在物质使用障碍治疗样本中，应对动机调节边缘人格特征与酒精、大麻和处方阿片类药物使用障碍症状之间的关系。

• DOI: 10.1037/per0000385
• 发表时间: 2020
• 期刊: Personality disorders
• 作者: Vest,NoelA;Tragesser,Sarah
• 通讯作者: Tragesser,Sarah

Identification of KRT16 as a target of an autoantibody response in complex regional pain syndrome.

• DOI: 10.1016/j.expneurol.2016.10.011
• 发表时间: 2017-01
• 期刊: Experimental neurology
• 影响因子: 5.3
• 作者: Tajerian M;Hung V;Khan H;Lahey LJ;Sun Y;Birklein F;Krämer HH;Robinson WH;Kingery WS;Clark JD
• 通讯作者: Clark JD