The impact of e-cigarette advertising and warning labels on e-cigarette use behavior in adolescents

电子烟广告和警告标签对青少年电子烟使用行为的影响

• 批准号: 10436640
• 负责人: Kathleen A. GARRISON
• 金额: $ 8.34万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436640
• 关键词: Adolescent; Advertisements; Age; Attitude; Behavior; Brain; Categories; Chemicals; Cigarette; Electronic cigarette; Enrollment; Ensure; Event; Exposure to; Fruit; Functional Magnetic Resonance Imaging; Future; Goals; Health; Health behavior; Image; Knowledge; Label; Life; Link; Longitudinal Surveys; Marketing; Measures; Medial; Memory; Nucleus Accumbens; Patient Self-Report; Pattern; Prefrontal Cortex; Productivity; Reporting; Risk; Smoking; Surveys; Testing; Time; Tobacco use; Youth; cigarette advertising; cigarette warning label; electronic cigarette use; follow-up; imaging study; parent project; relating to nervous system; response; risk perception; tobacco products; tobacco regulation; visual tracking; warning label

PROJECT SUMMARY E-cigarettes are now the most common tobacco product used by youth in the US. Among the primary reasons youth report for having tried e-cigarettes are low risk perceptions and appealing flavors. Youth have poor knowledge of e-cigarette health risks, which only recently have a required warning label. At the same time, e- cigarettes are advertised in sweet and fruit flavors that increase their appeal to youth. A recent study by our team indicated that these factors also interact –images of sweet/fruit flavors on e-cigarette advertisements distracted youth from warning labels. To better understand how these factors impact e-cigarette use by youth, there is a critical need for measures linking exposure to e-cigarette advertising and warning labels to future e- cigarette use behavior. Functional magnetic resonance imaging (fMRI) has been used to identify brain activity patterns that predict future health behavior including tobacco use beyond self-report. Multiple fMRI studies indicate that the medial prefrontal cortex (MPFC) response to cigarette warnings predicts future smoking. Other fMRI studies indicate that the nucleus accumbens (NAc) response to advertisements predicts purchasing. The parent project uses a similar brain-as-predictor approach with fMRI and eye tracking to link neural responses to e-cigarette advertising and warning labels to future e-cigarette use behavior in youth. Youth (ages 13-19, N=80) view e-cigarette advertisements and warning labels in fMRI and complete quarterly follow-up surveys for one year. MPFC and NAc activity will be measured and tested for relationships with future e-cigarette attitudes, intentions and use. Additional fMRI control conditions will allow us to test the specific impact of different categories of warning labels and different e-cigarette flavors, and the interactions between these factors, including their impact on memory for warning labels. Aim 1 tests the hypothesis that greater MPFC activity as adolescents view e-cigarette warning labels will be related to more negative e- cigarette attitudes and intentions and lower use of e-cigarettes in the next year. Exploratory Aim 1.1 compares MPFC response between warning labels about addictiveness versus chemical constituents. Aim 2 tests the hypothesis that greater NAc activity as adolescents view e-cigarette advertisements will be related to more positive e-cigarette attitudes and intentions and greater use of e-cigarettes in the next year. Exploratory Aim 2.1 compares the relative value of multiple measures –fMRI, eye tracking and surveys –to predict future e- cigarette use in the next year. Aim 3 replicates and extends our recent study by testing whether images of flavors on e-cigarette advertisements distract adolescents from warning labels. Overall, this project should generate critical evidence on the impact of e-cigarette advertising and warning labels on e-cigarette use behavior in youth, and inform FDA efforts to regulate e-cigarette flavors, labeling and marketing. Important information will also be generated on the relative value of multiple measures to predict future e-cigarette use. The specific aims have not changed and will not change as a result of this proposed supplement.

项目摘要 电子烟现在是美国年轻人使用的最常见的烟草产品。主要原因之一 年轻人尝试电子烟的报告是低风险的看法和吸引人的口味。青年有穷 了解电子烟的健康风险，直到最近才要求警告标签。与此同时，e- 香烟的广告中有甜味和水果味，以增加对年轻人的吸引力。我们最近的一项研究表明， 研究小组指出，这些因素也相互作用-电子烟广告中的甜味/水果味图像 让年轻人远离警告标签为了更好地了解这些因素如何影响年轻人使用电子烟， 迫切需要采取措施，将接触电子烟广告和警告标签与未来的电子烟联系起来， 吸烟行为功能性磁共振成像（fMRI）已被用于识别大脑活动 预测未来健康行为的模式，包括自我报告以外的烟草使用。多项fMRI研究 研究表明，内侧前额叶皮层（MPFC）对香烟警告的反应可以预测未来的吸烟行为。 其他功能磁共振成像研究表明，对广告的反应预测了 purchasing.母项目使用类似的大脑作为预测器的方法，通过功能磁共振成像和眼动跟踪来联系 对电子烟广告的神经反应和对年轻人未来电子烟使用行为的警告标签。 青少年（13-19岁，N=80）在功能磁共振成像中查看电子烟广告和警告标签，并完成季度 跟踪调查一年。MPFC和NAc活动将被测量和测试与以下因素的关系： 未来电子烟的态度、意图和使用。额外的功能磁共振成像控制条件将允许我们测试 不同类别的警告标签和不同的电子烟口味的具体影响，以及相互作用 这些因素之间的关系，包括它们对警告标签记忆的影响。目标1检验假设， 更大的MPFC活动，因为青少年认为电子烟警告标签将与更负面的电子烟有关， 吸烟态度和意图以及明年电子烟的使用量减少。探索性目标1.1比较 关于成瘾性与化学成分的警告标签之间的MPFC反应。目标2测试 假设青少年观看电子烟广告时NAc活动更大， 积极的电子烟态度和意图，以及明年更多地使用电子烟。探索性目标 2.1比较了多种测量方法的相对值--功能磁共振成像、眼动跟踪和调查--来预测未来的电子商务。 明年的香烟。Aim 3复制并扩展了我们最近的研究，测试了 电子烟广告上的味道分散了青少年对警告标签的注意力。总的来说，这个项目应该 就电子烟广告和警告标签对电子烟使用的影响提供关键证据 行为，并告知FDA努力规范电子烟口味，标签和营销。重要 还将生成关于多种措施的相对价值的信息，以预测未来的电子烟使用。 具体目标没有改变，也不会因为拟议的补充而改变。