Neural circuit mechanisms controlling non-homeostatic feeding
Neural circuit mechanisms controlling non-homeostatic feeding
批准号:
10429408
负责人:
Sarah Stern
金额:
$5.06万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-03-01 至 2023-12-31
关键词:
AdultAdvertisingAmygdaloid structureBehaviorBehavioralBinge EatingBrainBrain regionComplexCuesDataDevelopmentEatingFeeding behaviorsFoodGeneticGrantHungerHyperphagiaInstinctInsula of ReilKnowledgeLeadLearningMediator of activation proteinMemoryMentorsModelingMolecularMolecular ProfilingMusNeuronsObesityObesity EpidemicOverweightPhaseResearchRoleStimulusTechniquesTelevisionTestingWeight Gainbehavioral outcomecell typeexperiencefeedingin vivo calcium imagingneural circuitnovel therapeuticsobesity treatmentresponsetherapy development
中文摘要
强迫性饮食是美国肥胖症流行的主要原因,超过35%的美国人患有这种疾病
英文摘要
Compulsive eating is a major contributor to the obesity epidemic in the US, as over 35% of
adults are now classified as overweight or obese. Behavioral outcomes such as compulsive
eating derive from a complex interaction of genetics, innate behaviors and learning about
previous experiences. Cue-food associations (e.g. advertising, eating in front of the television,
etc.) that are formed during periods of hunger lead to long-lasting memories that control non-
homeostatic overconsumption. However, the neural circuitry, and specifically the molecular cell
types, governing this behavior are not well defined. Using an original paradigm that induced
overconsumption in sated mice with contextual cues, I have established a role of the insular
cortex, and specifically Nos1 neurons within the insular cortex, as critical mediators of learned
overconsumption. These neurons do not play a role in homeostatic feeding itself and are
therefore hypothesized to provide top down control of homeostatic feeding circuitry to control
food intake. Moreover, a projection from the insular cortex to the central amygdala is necessary
to generate this overconsumption response. In the mentored K-phase of this grant, I analyzed
the role of a molecularly defined cortical-amygdalar circuit in overconsumption and determined
the amygdala targets of insular cortex Nos1 neurons. In the independent phase (R00), I will
further this understanding by employing in vivo calcium imaging to the insula Nos1 to central
amygdala circuit during behavior. I will also utilize retrograde tracing techniques to examine the
regions and molecularly profile the cell types that directly project to the insular cortex neurons
that control overconsumption, and test causally how they are functionally involved in non-
homeostatic feeding. Together, these data will establish a cell-type specific circuit through the
insular cortex that controls overconsumption in response to environmental stimuli. This data will
expand the knowledge of higher-order brain regions involved in feeding behavior and may lead
to the development of novel therapeutic avenues to control overeating.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Identifying neurons for interoception using simultaneous profiling of activity- and projection- specific populations
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批准号:10687590
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项目类别:
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资助金额:$169.98万
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财政年份:2023
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负责人:Sarah Stern
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依托单位:
Neural circuit mechanisms controlling non-homeostatic feeding
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批准号:10327339
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项目类别:
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资助金额:$24.9万
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财政年份:2020
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负责人:Sarah Stern
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依托单位:
Neural circuit mechanisms controlling non-homeostatic feeding
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批准号:9891700
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项目类别:
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资助金额:$16.32万
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财政年份:2020
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负责人:Sarah Stern
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依托单位:
Neural circuit mechanisms controlling non-homeostatic feeding
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批准号:10545728
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项目类别:
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资助金额:$24.9万
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财政年份:2020
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负责人:Sarah Stern
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依托单位:
Neural circuit mechanisms controlling non-homeostatic feeding
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批准号:10297901
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项目类别:
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资助金额:$24.9万
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财政年份:2020
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负责人:Sarah Stern
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依托单位:
Neural circuit mechanisms controlling non-homeostatic feeding
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批准号:10532559
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项目类别:
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资助金额:$5.06万
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财政年份:2020
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负责人:Sarah Stern
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依托单位:
Neural circuitry underlying cue-induced feeding
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批准号:9124001
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项目类别:
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资助金额:$5.43万
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财政年份:2016
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负责人:Sarah Stern
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依托单位:
Astrocytic Contributions to Long Term Memory & Synaptic Plasticity
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批准号:8267253
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项目类别:
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资助金额:$3.42万
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财政年份:2010
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负责人:Sarah Stern
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依托单位:
Astrocytic Contributions to Long Term Memory & Synaptic Plasticity
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批准号:8579807
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项目类别:
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资助金额:$2.55万
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财政年份:2010
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负责人:Sarah Stern
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依托单位:
Astrocytic Contributions to Long Term Memory & Synaptic Plasticity
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批准号:8402406
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项目类别:
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资助金额:$3.3万
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财政年份:2010
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负责人:Sarah Stern
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依托单位:
Astrocytic Contributions to Long Term Memory & Synaptic Plasticity
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批准号:8057719
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项目类别:
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资助金额:$4.14万
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财政年份:2010
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负责人:Sarah Stern
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依托单位:
国内基金
海外基金
小型类人猿合唱节奏的功能假说——宣
示社会关系(Social bond
advertising) ——验证研究
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批准号:
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项目类别:省市级项目
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资助金额:10.0万元
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批准年份:2025
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负责人:马海港
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依托单位: