Administrative Supplement to Increase Representation in a Mindfulness Training Trial

增加正念训练试验代表性的行政补充

• 批准号: 10434369
• 负责人: Ruchika Shaurya Prakash
• 金额: $ 38.39万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434369
• 关键词: Adherence; Administrative Supplement; Age; Age-associated memory impairment; Architecture; Attention; Behavioral; Brain; Cognition; Control Groups; Education; Elderly; Future; Goals; Impaired cognition; Individual; Intervention; Laboratories; Lateral; Life Style; Link; Maintenance; Matched Group; Measures; Mediating; Mind; Mindfulness Training; Nerve Degeneration; Neuronal Plasticity; Not Hispanic or Latino; Parents; Performance; Population; Prefrontal Cortex; Quality of life; Randomized; Rehabilitation therapy; Research; Research Design; Rest; Role; Sampling; Single-Blind Study; Testing; Time; Training; Training Programs; Well in self; Work; active control; active lifestyle; attentional control; base; cognitive benefits; cognitive function; cognitive rehabilitation; cognitive training; computerized; cost effective treatment; design; distraction; efficacy testing; emotion regulation; follow-up; improved; indexing; mindfulness; mindfulness meditation; mindfulness-based stress reduction; neural correlate; novel; parent grant; programs; racial and ethnic; randomized controlled design; recruit; relating to nervous system; satisfaction; tool; treatment effect

PARENT GRANT PROJECT SUMMARY The overarching goal of this project is to rigorously test the efficacy of mindfulness training as a cognitive rehabilitation tool to mitigate age-related cognitive decline. Although the last decade has seen an increase in the number of cognitive training studies in the elderly, the majority of studies focus on computerized task- specific cognitive training, resulting in enhanced performance on the task being trained, but weak transfer to other tasks in the same domain and no transfer to other domains. The proposed study, employing mindfulness training as a cognitive rehabilitation tool, is novel in its reconceptualization of traditional cognitive training approaches into a training program that first and foremost promotes concentrative attention, thereby targeting attentional control, and secondly, does so in a framework that cultivates acceptance and non-reactivity, thus prioritizing older adults’ increased socioemotional drive for emotional well-being and satisfaction. Our main hypothesis is that eight weeks of training in practices of mindfulness meditation, designed to increase concentrative attention and reduce the wandering tendencies of the mind, will increase performance on tasks of attentional control in the elderly, partially via mindfulness-induced neuronal plasticity in the intrinsic functional architecture of the brain. Using a single-blind, randomized controlled design, 120 older adults ages 65-85 will be assigned to either a mindfulness-based stress reduction (MBSR) group or an active lifestyle education control group matched for therapist contact time, engagement with the material, format of the intervention, a combination of experiential and didactic components, and perceived cognitive benefits. Assessments of dependent variables will be completed at pre-training, post-training, and then at a 12-month follow-up session. In Aim 1, we will investigate the short- and long-term impact of MBSR training on behavioral and neural correlates of attentional control (Aim 1.a & 1.b), and then examine the mediating role of mind- wandering and default-mode network connectivity in yielding attentional control benefits (Aim 1.c). Aim 2 investigates the efficacy of MBSR for far-transfer to abilities contributing to quality of life: broad laboratory- based and everyday measures of cognition (Aim 2.a), and emotion regulation strategies (Aim 2.b). The proposed work will establish the causal link between engagement in mindfulness practices and improved attentional control as well as identify reduced mind-wandering and default-mode network integrity as potential mechanisms of action through which mindfulness training exerts its effect on attentional control. Not only will the current study design offer an easily disseminable and cost effective treatment for cognitive decline in older adults, it will also provide a theoretical mechanism on which to base future cognitive rehabilitation designs, advancing the field of rehabilitation as a whole.

家长资助项目摘要 该项目的总体目标是严格测试正念训练作为认知训练的有效性 缓解与年龄相关的认知能力下降的康复工具。尽管过去十年有所增加 在老年人认知训练研究的数量中，大多数研究集中在计算机化任务上 特定的认知训练，导致训练任务的表现增强，但迁移能力较弱 同一域中的其他任务并且不会转移到其他域。拟议的研究采用正念 训练作为一种认知康复工具，其新颖之处在于它对传统认知训练的重新概念化 培训计划的方法首先要促进集中注意力，从而瞄准 其次，在培养接受性和不反应性的框架内进行注意力控制，从而 优先考虑老年人增加的社会情感驱动力，以实现情感健康和满意度。我们的主要 假设是八周的正念冥想练习训练，旨在提高 集中注意力并减少走神倾向，将提高任务绩效 老年人的注意力控制，部分是通过正念诱导的内在神经元可塑性 大脑的功能结构。采用单盲、随机对照设计，研究了 120 名老年人 65-85 将被分配到正念减压 (MBSR) 组或积极生活方式组 教育对照组与治疗师接触时间、材料参与度、治疗形式相匹配 干预、体验和教学成分的结合以及感知的认知益处。 因变量的评估将在训练前、训练后以及 12 个月后完成 后续会议。在目标 1 中，我们将研究 MBSR 培训对行为的短期和长期影响 和注意力控制的神经相关性（目标 1.a 和 1.b），然后检查心理的中介作用 徘徊和默认模式网络连接产生注意力控制优势（目标 1.c）。目标2 研究了MBSR对于远距离转移到有助于生活质量的能力的功效：广泛的实验室- 基于日常的认知测量（目标 2.a）和情绪调节策略（目标 2.b）。这 拟议的工作将建立参与正念练习和改进之间的因果关系 注意力控制以及识别减少走神和默认模式网络完整性的潜力 正念训练对注意力控制发挥作用的作用机制。不仅会 目前的研究设计为老年人认知能力下降提供了一种易于传播且具有成本效益的治疗方法 成人，它还将提供一个理论机制，作为未来认知康复设计的基础， 全面推进康复领域发展。

项目成果

Predicting response time variability from task and resting-state functional connectivity in the aging brain.

• DOI: 10.1016/j.neuroimage.2022.118890
• 发表时间: 2022-04-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Gbadeyan, Oyetunde;Teng, James;Prakash, Ruchika Shaurya
• 通讯作者: Prakash, Ruchika Shaurya

Mindfulness Meditation: Impact on Attentional Control and Emotion Dysregulation.

正念冥想：对注意力控制和情绪失调的影响。

• DOI: 10.1093/arclin/acab053
• 发表时间: 2021
• 期刊: Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
• 作者: Prakash,RuchikaShaurya

Trait mindfulness and emotion regulation responsiveness to negative affect in daily life.

特质正念和情绪调节对日常生活中负面影响的反应。

• DOI: 10.1007/s12671-022-01996-3
• 发表时间: 2022
• 期刊: Mindfulness
• 影响因子: 3.6
• 作者: Fisher,MeganE;Duraney,Elizabeth;Friess,Katherine;Whitmoyer,Patrick;Andridge,Rebecca;Prakash,RuchikaS
• 通讯作者: Prakash,RuchikaS

Using connectome-based models of working memory to predict emotion regulation in older adults.

• DOI: 10.1093/scan/nsad036
• 发表时间: 2023-07-25
• 期刊: SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
• 影响因子: 4.2
• 作者: Fisher, Megan E.;Teng, James;Gbadeyan, Oyetunde;Prakash, Ruchika S.
• 通讯作者: Prakash, Ruchika S.

Mindfulness and Attention: Current State-of-Affairs and Future Considerations.

• DOI: 10.1007/s41465-019-00144-5
• 发表时间: 2020-09
• 期刊: Journal of cognitive enhancement : towards the integration of theory and practice
• 作者: Prakash RS;Fountain-Zaragoza S;Kramer AF;Samimy S;Wegman J
• 通讯作者: Wegman J