Mouse Phenotyping Informatics Infrastructure - MP12

小鼠表型信息学基础设施 - MP12

• 批准号: 10430582
• 负责人: Steve Brown
• 金额: $ 7万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430582
• 关键词: Adult; Biological; Biomedical Research; Cell Line; Clinical; Communities; Data; Data Set; Disease; Documentation; Ensure; Feedback; Genes; Graph; Human; Infrastructure; Knockout Mice; Modeling; Mus; Phenotype; Publications; Quality Control; Research; Resources; Site; System; Testing; Training; Update; Visualization; Work; base; biomedical resource; data access; data acquisition; design; experience; follow-up; gene function; health data; improved; informatics infrastructure; insight; web portal; web site

Project summary The Knockout Mouse Phenotyping Project (KOMP) is a critical resource for biomedical research that provides unbiased gene to phenotype associations from genes with little or no-known function, supplying strains for follow-up mechanistic studies and integration across resources to provide new systematic insights into the underlying causes of rare and common disease. The MPI2 Consortium will continue to support KOMP2 and IMPC partners by providing data acquisition, analysis, visualisation, quality control and integration of this valuable dataset. Specifically The MPI2 partners will enhance the Mouse Phenotype portal improving the site layout and navigation for users and making improvements to gene, disease, publication, expression data pages making data more quickly accessible. We will containerise of the infrastructure underlying the web portal. these changes will ease deployment and therefore community re-use of the portal.

项目总结 基因敲除小鼠表型项目(KOMP)是生物医学研究的关键资源，它提供了 从功能很少或未知的基因无偏向表型关联，为菌株提供 跨资源的后续机制研究和整合，以提供对 罕见和常见疾病的根本原因。MPI2联盟将继续支持KOMP2和 IMPC通过提供数据采集、分析、可视化、质量控制和 有价值的数据集。特指 MPI2合作伙伴将增强鼠标表型门户，改进网站布局和导航 并对基因、疾病、出版物、表达数据页面进行改进，使数据更多 快速访问。我们将对网络门户基础设施进行集装箱化。这些变化将 简化门户的部署，从而实现社区重用。