Mouse Phenotyping Informatics Infrastruture - MP12

小鼠表型信息学基础设施 - MP12

• 批准号: 8719763
• 负责人: Steve Brown
• 金额: $ 245万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719763
• 关键词: Archives; Area; Biological; Biological Assay; Biological Models; Biomedical Research; CXCL2 gene; Clinical Research; Communities; Complex; Data; Data Analyses; Data Coordinating Center; Data Display; Data Set; Data Sources; Databases; Deposition; Development; Ensure; Environment; Foundations; Future; Generations; Genetic; Genome; Genomics; Goals; Health; Human; Informatics; Institutes; Internet; Investigation; Life; Mining; Modeling; Mus; Mutagenesis; Mutant Strains Mice; Pathway interactions; Phenotype; Procedures; Process; Production; Qualifying; Quality Control; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Specialist; Staging; System; Testing; The Jackson Laboratory; Trust; United States National Institutes of Health; Validation; computerized data processing; data management; design; flexibility; gene function; genome wide association study; human disease; interest; mouse model; mutant; prevent; programs; prototype; tool

DESCRIPTION (provided by applicant): The K0MP2 data are a critical resource for biomedical research, will inform human disease studies, be integrated with existing resources and will be accessed, analyzed and mined by mouse biologists, translational researchers, clinicians and wider biomedical community. The MIP2 project will support the K0MP2 project by providing the Data Coordination Centre which will process the complex phenotypic data provide access via a web portal. The DCC aims are to collect and store valid data as it appears throughout the project, to provide unified access to these data for specialist and non specialist users via the web and programmatically, and to support complex queries and statistical analyses. The project has several distinct components and tasks: The Pheno-DCC will validate, perform quality control and manage data acquired dynamically from centres. This will ensure data are robust and allow progress tracking of data at all stages of processing. Specialist data wranglers will manage this process and will interact with the users of the data to ensure user interfaces support the needs of the varied community who will access these data. The statistical and annotation pipelines and environment which will analyze raw data and summarize data for each mutant and assay for presentation to users. A supporting core database, the Core Data Archive, which will store all project data, provide programmatic access, push data to external resources such as NCBI and the Jackson Laboratory and critically provide data for the user interfaces. A single point of entry web portal hosted at www.knockoutmouse.org which will present data to users. I, integrate data from parallel mouse phenotyping projects and provide access to a statistical analysis and query environment Integrate K0MP2 data via biomedical databases at the EBI to ensure that the data are widely distributed to mouse biologists and other scientists .

描述（由申请人提供）：K0MP2 数据是生物医学研究的重要资源，将为人类疾病研究提供信息，与现有资源整合，并将由小鼠生物学家、转化研究人员、临床医生和更广泛的生物医学界访问、分析和挖掘。 MIP2 项目将通过提供数据协调中心来支持 K0MP2 项目，该中心将处理复杂的表型数据并通过门户网站提供访问。 DCC 的目标是收集和存储整个项目中出现的有效数据，通过网络和编程方式为专家和非专家用户提供对这些数据的统一访问，并支持复杂的查询和统计分析。该项目有几个不同的组成部分和任务： Pheno-DCC 将验证、执行质量控制并管理从中心动态获取的数据。这将确保数据的稳健性，并允许在处理的所有阶段跟踪数据的进度。专业数据管理员将管理此过程，并与数据用户进行交互，以确保用户界面支持访问这些数据的不同社区的需求。 统计和注释管道和环境将分析原始数据并总结每个突变体和分析的数据以呈现给用户。 支持的核心数据库是核心数据存档，它将存储所有项目数据、提供编程访问、将数据推送到 NCBI 和杰克逊实验室等外部资源，并为用户界面提供关键数据。 托管在 www.knockoutmouse.org 上的单点入口门户网站，它将向用户呈现数据。 I，整合来自并行小鼠表型项目的数据，并提供对统计分析和查询环境的访问通过EBI的生物医学数据库整合K0MP2数据，以确保数据广泛分发给小鼠生物学家和其他科学家。