Mouse Phenotyping Informatics Infrastruture - MP12

描述(申请人提供)：K0MP2数据是生物医学研究的关键资源，将为人类疾病研究提供信息，与现有资源整合，将由小鼠生物学家、翻译研究人员、临床医生和更广泛的生物医学界访问、分析和挖掘。MIP2项目将通过提供数据协调中心来支持K0MP2项目，该中心将处理复杂的表型数据，并通过一个门户网站提供访问。DCC的目标是收集和存储整个项目中出现的有效数据，通过网络和编程为专家和非专家用户提供对这些数据的统一访问，并支持复杂的查询和统计分析。该项目有几个不同的组成部分和任务：PANO-DCC将验证、执行质量控制和管理从各中心动态获得的数据。这将确保数据稳健，并允许在处理的所有阶段跟踪数据的进展情况。专业数据管理人员将管理这一过程，并将与数据用户互动，以确保用户界面支持将访问这些数据的不同社区的需求。统计和注释管道和环境，它将分析原始数据并汇总每个突变和化验的数据，以便呈现给用户。核心数据档案是一个辅助的核心数据库，它将存储所有项目数据，提供程序访问，将数据推送到NCBI和杰克逊实验室等外部资源，并关键地为用户界面提供数据。一个单一的入口点网络门户网站，托管在www.KNOKKOUTMUSE.org上，它将向用户提供数据。I、整合来自平行小鼠表型项目的数据，并提供对统计分析和查询环境的访问，通过EBI的生物医学数据库整合K0MP2数据，以确保数据被广泛分发给小鼠生物学家和其他科学家。

DESCRIPTION (provided by applicant): The K0MP2 data are a critical resource for biomedical research, will inform human disease studies, be integrated with existing resources and will be accessed, analyzed and mined by mouse biologists, translational researchers, clinicians and wider biomedical community. The MIP2 project will support the K0MP2 project by providing the Data Coordination Centre which will process the complex phenotypic data provide access via a web portal. The DCC aims are to collect and store valid data as it appears throughout the project, to provide unified access to these data for specialist and non specialist users via the web and programmatically, and to support complex queries and statistical analyses. The project has several distinct components and tasks: The Pheno-DCC will validate, perform quality control and manage data acquired dynamically from centres. This will ensure data are robust and allow progress tracking of data at all stages of processing. Specialist data wranglers will manage this process and will interact with the users of the data to ensure user interfaces support the needs of the varied community who will access these data. The statistical and annotation pipelines and environment which will analyze raw data and summarize data for each mutant and assay for presentation to users. A supporting core database, the Core Data Archive, which will store all project data, provide programmatic access, push data to external resources such as NCBI and the Jackson Laboratory and critically provide data for the user interfaces. A single point of entry web portal hosted at www.knockoutmouse.org which will present data to users. I, integrate data from parallel mouse phenotyping projects and provide access to a statistical analysis and query environment Integrate K0MP2 data via biomedical databases at the EBI to ensure that the data are widely distributed to mouse biologists and other scientists .