Purchase of a SARRP 200 Platform for Irradiation

项目摘要 此应用程序申请购买独立的精密x射线辐照器和成像仪器的资金 集成锥束CT(CBCT)：Xstrahl小动物辐射研究平台-200 200)。这台仪器是应费城维斯塔尔研究所的教职员工要求的。威斯塔尔 该研究所是美国历史最悠久的独立生物医学研究所，拥有充满活力和高度 在癌症生物学、免疫学和疫苗方面进行尖端研究的协作教员。这个 该研究所在单抗治疗和癌症生物学方面拥有悠久的研究成功历史 (Stelara®)和疫苗(RotaTeq©)，包括第二种进入临床测试的新冠肺炎疫苗 在美国。选定的仪器，SARRP-200，引入了关键的新功能 Wistar研究人员，他们目前无法在小动物身上进行图像引导放射治疗 (小鼠)，或使用我们目前的系统使用小鼠的全身辐射进行骨髓消融。后者 我们迫切需要技术来创造和表征人性化的小鼠(有人的小鼠 免疫系统)。我们对人源化小鼠的研究是几位研究人员共同的开创性努力 在研究所，对于这个项目和其他项目，预计SARRP-200将是一个关键的协同作用 Wistar研究工作的平台。由于IACUC对免疫运输的限制- 受损的小鼠，Wistar的教职员工无法使用附近两个SARRP中的任何一个 宾夕法尼亚大学。然而，我们利用了附近同事的专业知识， 他们被列入我们的顾问委员会和项目管理团队。安装和立即安装 SARRP-200的使用将得到我们训练有素的人员、我们的内部咨询人员的帮助 委员会，以及我们经验丰富的项目管理团队，其中包括放射肿瘤学和 宾夕法尼亚大学的医学物理学人员。我们计划购买一架SARRP-200 将用一个脆弱的机动平台取代一个有30年历史的铯辐照器，该平台经常 年久失修。所要求的仪器将放置在细胞和动物照射核心内，在 宾夕法尼亚州费城维斯塔尔学院东楼底层的指定空间，有 直接进入指定的程序室和实验动物设施。计划中的采购 预计将为Wistar研究人员提供重要的新功能，并为 对已经高度合作的教职员工的研究。

Project Summary This application requests funds for a stand-alone precision x-ray irradiator and imaging instrument with integrated cone beam CT (CBCT): the Xstrahl Small Animal Radiation Research Platform-200 (SARRP- 200). This instrument is requested by the faculty at The Wistar Institute in Philadelphia. The Wistar Institute is the nation’s oldest independent biomedical research institute, with an energized and highly collaborative faculty who perform cutting-edge research on cancer biology, immunology and vaccines. The Institute boasts a long history of research success in monoclonal antibody therapy and cancer biology (Stelara®) and vaccines (RotaTeq©), including the second COVID-19 vaccine to move into clinical testing in the United States. The instrument selected, the SARRP-200, introduces critical new capabilities for Wistar Investigators, who are currently unable to perform image-guided radiotherapy in small animals (mice), or to use whole-body radiation of mice for myelo-ablation using our current system. The latter technique is urgently needed for our ability to create and characterize humanized mice (mice with human immune systems). Our studies on humanized mice is a pioneering effort shared by several Investigators at the Institute, and for this and other projects it is expected that the SARRP-200 will be a critical synergy platform for Wistar research efforts. Because of IACUC restrictions regarding the transport of immuno- compromised mice, Wistar faculty are unable to use either of the two SARRPs located at the nearby University of Pennsylvania. However, we have taken advantage of the expertise of our nearby colleagues, and they are listed on our advisory board and program management team. Installation and immediate usage of the SARRP-200 will be facilitated by our already-trained personnel, our Internal Advisory Committee, and by our experienced Program Management team, which includes radiation oncology and medical physics personnel from the University of Pennsylvania. Our planned purchase of a SARRP-200 will replace a thirty year old cesium irradiator with a fragile motorized platform that is subject to frequent disrepair. The requested instrument will be placed within the Cell and Animal Irradiation Core, in designated space on the ground floor of the East Building at the Wistar Institute in Philadelphia PA, with direct access to a designated procedure room and the Laboratory Animal Facility. The planned purchase of the SARRP-200 is expected to offer significant new capabilities to Wistar researchers, and to energize the research of an already highly collaborative faculty.