Purchase of a SARRP 200 Platform for Irradiation

购买 SARRP 200 辐照平台

• 批准号: 10430904
• 负责人: Maureen E. Murphy
• 金额: $ 60万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430904
• 关键词: Advisory Committees; Animals; Biomedical Research; Bone Marrow Purging; COVID-19 vaccine; Cancer Biology; Cells; Cesium; Faculty; Floor; Funding; Human; Human Resources; IACUC; Imaging Device; Immune system; Immunocompromised Host; Immunology; Institutes; Laboratory Animals; Medical; Monoclonal Antibody Therapy; Mus; Pennsylvania; Philadelphia; Physics; Procedures; Radiation; Radiation Oncology; Recording of previous events; Request for Applications; Research; Research Institute; Research Personnel; Roentgen Rays; System; Techniques; The Wistar Institute; Training; United States; Universities; Vaccines; Whole-Body Irradiation; animal facility; cone-beam computed tomography; experience; humanized mouse; image guided radiation therapy; instrument; irradiation; programs; research clinical testing; success; synergism

Project Summary This application requests funds for a stand-alone precision x-ray irradiator and imaging instrument with integrated cone beam CT (CBCT): the Xstrahl Small Animal Radiation Research Platform-200 (SARRP- 200). This instrument is requested by the faculty at The Wistar Institute in Philadelphia. The Wistar Institute is the nation’s oldest independent biomedical research institute, with an energized and highly collaborative faculty who perform cutting-edge research on cancer biology, immunology and vaccines. The Institute boasts a long history of research success in monoclonal antibody therapy and cancer biology (Stelara®) and vaccines (RotaTeq©), including the second COVID-19 vaccine to move into clinical testing in the United States. The instrument selected, the SARRP-200, introduces critical new capabilities for Wistar Investigators, who are currently unable to perform image-guided radiotherapy in small animals (mice), or to use whole-body radiation of mice for myelo-ablation using our current system. The latter technique is urgently needed for our ability to create and characterize humanized mice (mice with human immune systems). Our studies on humanized mice is a pioneering effort shared by several Investigators at the Institute, and for this and other projects it is expected that the SARRP-200 will be a critical synergy platform for Wistar research efforts. Because of IACUC restrictions regarding the transport of immuno- compromised mice, Wistar faculty are unable to use either of the two SARRPs located at the nearby University of Pennsylvania. However, we have taken advantage of the expertise of our nearby colleagues, and they are listed on our advisory board and program management team. Installation and immediate usage of the SARRP-200 will be facilitated by our already-trained personnel, our Internal Advisory Committee, and by our experienced Program Management team, which includes radiation oncology and medical physics personnel from the University of Pennsylvania. Our planned purchase of a SARRP-200 will replace a thirty year old cesium irradiator with a fragile motorized platform that is subject to frequent disrepair. The requested instrument will be placed within the Cell and Animal Irradiation Core, in designated space on the ground floor of the East Building at the Wistar Institute in Philadelphia PA, with direct access to a designated procedure room and the Laboratory Animal Facility. The planned purchase of the SARRP-200 is expected to offer significant new capabilities to Wistar researchers, and to energize the research of an already highly collaborative faculty.

项目摘要 该申请要求资金提供独立精确的X射线辐照器和成像工具 综合锥束CT（CBCT）：Xstrahl小动物辐射研究平台200（Sarrp- 200）。费城维斯塔尔研究所的教师要求该工具。 Wistar 研究所是美国最古老的独立生物医学研究所，拥有充满活力且高度的 对癌症生物学，免疫学和疫苗进行尖端研究的合作教师。这 研究所拥有单克隆抗体疗法和癌症生物学的悠久研究历史 （Stelara®）和疫苗（RotateQ©），包括第二次Covid-19疫苗进入临床测试 在美国。选定的仪器SARRP-200引入了关键的新功能 Wistar研究人员，他们目前无法在小动物中进行图像引导的放射疗法 （小鼠），或使用当前系统使用小鼠的全身辐射进行骨髓。后来 迫切需要技术才能创建和表征人性化的小鼠（与人类的小鼠 免疫系统）。我们对人性化小鼠的研究是几位研究者分享的开创性工作 在研究所，对于这个和其他项目，预计SARRP-200将是关键的协同作用 Wistar研究工作平台。由于IACUC关于免疫运输的限制 受损的老鼠，维斯塔尔教师无法使用附近的两个sarrps中的任何一个 宾夕法尼亚大学。但是，我们已经利用了附近同事的专业知识， 它们被列入我们的顾问委员会和计划管理团队。安装和立即 我们已经训练的人员，我们的内部咨询 委员会以及我们经验丰富的计划管理团队，包括辐射肿瘤学和 宾夕法尼亚大学的医学物理人员。我们计划购买SARRP-200 将用一个易碎的电动平台代替30岁的铯辐照器 失修。所请求的仪器将放置在细胞和动物辐照芯中， 在费城宾夕法尼亚州的Wistar Institute的东楼底楼指定的空间，与 直接进入指定的程序室和实验室动物设施。计划购买 预计SARRP-200将为Wistar研究人员提供重要的新能力，并为 对已经高度协作的教师的研究。