Purchase of a SARRP 200 Platform for Irradiation

项目摘要 该申请要求资金用于独立的精密X射线辐照器和成像仪器， 集成锥形束CT（CBCT）：Xstrahl小动物辐射研究平台-200（SARRP- 200）。该仪器是由费城Wistar研究所的教师要求的。将Wistar 研究所是美国最古老的独立生物医学研究所，拥有一个充满活力和高度 在癌症生物学，免疫学和疫苗方面进行尖端研究的合作教师。的 研究所在单克隆抗体治疗和癌症生物学方面拥有悠久的研究历史 （Stelara®）和疫苗（RotaTeq©），包括进入临床测试的第二种COVID-19疫苗 在美国选择的仪器，SARRP-200，引入了关键的新功能， Wistar研究者目前无法在小动物中进行图像引导放射治疗 （小鼠），或使用我们目前的系统使用小鼠的全身辐射进行骨髓消融。后者 我们迫切需要技术来创造和表征人源化小鼠（具有人 免疫系统）。我们对人源化小鼠的研究是几个研究人员共同的开创性努力 在该研究所，对于这个项目和其他项目，预计SARRP-200将是一个关键的协同作用 为Wistar研究工作提供平台。由于IACUC对免疫转运的限制， 受损的小鼠，Wistar教师无法使用位于附近的两个SARRP中的任何一个 宾夕法尼亚大学.不过，我们利用了附近同事的专业知识， 他们被列入我们的顾问委员会和项目管理团队。安装和立即 我们已经培训过的人员、我们的内部咨询人员 委员会，并由我们经验丰富的项目管理团队，其中包括放射肿瘤学和 宾夕法尼亚大学的医学物理学人员。我们计划购买的SARRP-200 将用一个脆弱的机动平台取代一个30年前的铯辐照器， 失修。所需仪器将放置在细胞和动物辐照中心内， 位于宾夕法尼亚州费城Wistar研究所东楼一楼的指定空间， 直接进入指定的手术室和实验室动物设施。计划采购 预计SARRP-200将为Wistar研究人员提供重要的新功能，并为 一个已经高度合作的学院的研究。

Project Summary This application requests funds for a stand-alone precision x-ray irradiator and imaging instrument with integrated cone beam CT (CBCT): the Xstrahl Small Animal Radiation Research Platform-200 (SARRP- 200). This instrument is requested by the faculty at The Wistar Institute in Philadelphia. The Wistar Institute is the nation’s oldest independent biomedical research institute, with an energized and highly collaborative faculty who perform cutting-edge research on cancer biology, immunology and vaccines. The Institute boasts a long history of research success in monoclonal antibody therapy and cancer biology (Stelara®) and vaccines (RotaTeq©), including the second COVID-19 vaccine to move into clinical testing in the United States. The instrument selected, the SARRP-200, introduces critical new capabilities for Wistar Investigators, who are currently unable to perform image-guided radiotherapy in small animals (mice), or to use whole-body radiation of mice for myelo-ablation using our current system. The latter technique is urgently needed for our ability to create and characterize humanized mice (mice with human immune systems). Our studies on humanized mice is a pioneering effort shared by several Investigators at the Institute, and for this and other projects it is expected that the SARRP-200 will be a critical synergy platform for Wistar research efforts. Because of IACUC restrictions regarding the transport of immuno- compromised mice, Wistar faculty are unable to use either of the two SARRPs located at the nearby University of Pennsylvania. However, we have taken advantage of the expertise of our nearby colleagues, and they are listed on our advisory board and program management team. Installation and immediate usage of the SARRP-200 will be facilitated by our already-trained personnel, our Internal Advisory Committee, and by our experienced Program Management team, which includes radiation oncology and medical physics personnel from the University of Pennsylvania. Our planned purchase of a SARRP-200 will replace a thirty year old cesium irradiator with a fragile motorized platform that is subject to frequent disrepair. The requested instrument will be placed within the Cell and Animal Irradiation Core, in designated space on the ground floor of the East Building at the Wistar Institute in Philadelphia PA, with direct access to a designated procedure room and the Laboratory Animal Facility. The planned purchase of the SARRP-200 is expected to offer significant new capabilities to Wistar researchers, and to energize the research of an already highly collaborative faculty.