Strengthening COVID-19 prevention strategies via wastewater surveillance in a Northern Plains Tribe

通过北部平原部落的废水监测加强 COVID-19 预防策略

• 批准号: 10436763
• 负责人: Jeffrey A Henderson
• 金额: $ 51.67万
• 依托单位: BLACK HILLS CTR/AMERICAN INDIAN HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436763
• 关键词: 2019-nCoV; Address; Affect; Alaska Native; American Indians; Attitude; Behavioral; Businesses; COVID-19; COVID-19 pandemic; COVID-19 prevention; COVID-19 surveillance; Cessation of life; Cheyenne; Chronic; Clinical Data; Color; Communicable Diseases; Communities; Coronavirus; Detection; Diagnostic Reagent Kits; Disease; Disease Outbreaks; Disease Surveillance; Emergency response; Environmental Impact; Environmental Monitoring; Epidemic; Ethics; Ethnic group; Future; Generations; Geographic state; Goals; Health; Housing; Incidence; Indian reservation; Infectious Agent; Infrastructure; Knowledge; Mind; Northern Plains Tribe; Prevention strategy; Process; Qualitative Methods; Research; Research Personnel; Reservations; Resources; Rivers; Running; Rural; Schools; Sioux Indians; Smallpox; South Dakota; Spanish flu; Speed; Surveillance Program; System; Testing; Teton Sioux Indian; Thinking; Travel; Tribes; United States; United States Indian Health Service; Viral; Virus; density; design; effectiveness evaluation; epidemiologic data; experience; frontier; multidisciplinary; northern plains; novel coronavirus; pandemic disease; personal protective equipment; programs; public health emergency; racial and ethnic; screening; social; tribal community; tribal leader; tribal member; wastewater surveillance; wastewater testing

Despite the abundance of clinical and epidemiologic data collected during this pandemic, relatively little focus has been paid to the examination of infectious agents through bulk wastewater detection and epidemiological data that is particularly well-suited for disease surveillance in remote, frontier settings such as the CRST Reservation. The goal of this application is to develop and implement a 15-community wastewater testing program for viral contaminants, including SARS-CoV-2, to better understand the utility of wastewater testing and COVID-19 or other viral outbreaks in this remote, low-resourced, and relatively low-density Tribal community. We will use our highly collaborative, multidisciplinary team of Native investigators to develop and implement, and evaluate the effectiveness of a viral wastewater sequencing testing program in a very rural and remote Northern Plains Lakota Reservation. Therefore, we propose to leverage our 20-year, long-running partnership with CRST to address the following Specific Aims: 1. Use a highly participatory approach to design, garner approval for, and implement a wastewater testing system in a large Tribal reservation community. This community surveillance approach will screen for viral isolates, including SARS-CoV-2, in coordination with CRST’s preexisting COVID-19 surveillance system; and 2. Deploy qualitative methods to examine 16 key Tribal stakeholders’ and Tribal members’ attitudes towards this new community wastewater testing approach and, ultimately, how this new environmental testing effort affects Tribal members socially, ethically, and behaviorally; and 3. Seek to codify this new resource into the Tribe’s public health emergency response program, thereby enhancing the Tribe’s capacity for future viral and other likely epidemic and pandemic outbreaks.

尽管在这次大流行期间收集了丰富的临床和流行病学数据，但相对 很少关注通过大量废水检测和检测来检查传染病病原体 特别适合偏远边疆地区疾病监测的流行病学数据 例如CRST预订部。 该应用程序的目标是开发和实施15个社区的废水测试 针对包括SARS-CoV-2在内的病毒污染物的计划，以更好地了解废水的用途 在这个偏远、低资源和相对低密度的地方检测和新冠肺炎或其他病毒爆发 部落社区。 我们将利用我们高度协作的多学科土著调查团队来开发和 实施并评估病毒废水测序测试程序的有效性 农村和偏远的北部平原拉科塔保护区。 因此，我们建议利用我们与CRST长达20年的长期合作伙伴关系来解决 以下是具体目标： 1.使用高度参与性的方法来设计、获得批准和实施废水 在一个大型部落保留社区中测试系统。这种社区监督方法将 与CRST原有的新冠肺炎合作，筛查包括SARS-CoV-2在内的病毒株 监视系统；以及 2.部署定性方法，审查16个主要部落利益攸关方和部落成员的 对这种新的社区污水测试方法的态度，以及最终如何 新的环境检测工作在社会、伦理和行为上影响部落成员； 3.寻求将这一新资源编入部落的公共卫生应急计划， 从而增强了部落应对未来病毒和其他可能的流行病和大流行的能力 疫情爆发。