Strengthening COVID-19 prevention strategies via wastewater surveillance in a Northern Plains Tribe

通过北部平原部落的废水监测加强 COVID-19 预防策略

• 批准号: 10436763
• 负责人: Jeffrey A Henderson
• 金额: $ 51.67万
• 依托单位: BLACK HILLS CTR/AMERICAN INDIAN HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436763
• 关键词: 2019-nCoV; Address; Affect; Alaska Native; American Indians; Attitude; Behavioral; Businesses; COVID-19; COVID-19 pandemic; COVID-19 prevention; COVID-19 surveillance; Cessation of life; Cheyenne; Chronic; Clinical Data; Color; Communicable Diseases; Communities; Coronavirus; Detection; Diagnostic Reagent Kits; Disease; Disease Outbreaks; Disease Surveillance; Emergency response; Environmental Impact; Environmental Monitoring; Epidemic; Ethics; Ethnic group; Future; Generations; Geographic state; Goals; Health; Housing; Incidence; Indian reservation; Infectious Agent; Infrastructure; Knowledge; Mind; Northern Plains Tribe; Prevention strategy; Process; Qualitative Methods; Research; Research Personnel; Reservations; Resources; Rivers; Running; Rural; Schools; Sioux Indians; Smallpox; South Dakota; Spanish flu; Speed; Surveillance Program; System; Testing; Teton Sioux Indian; Thinking; Travel; Tribes; United States; United States Indian Health Service; Viral; Virus; density; design; effectiveness evaluation; epidemiologic data; experience; frontier; multidisciplinary; northern plains; novel coronavirus; pandemic disease; personal protective equipment; programs; public health emergency; racial and ethnic; screening; social; tribal community; tribal leader; tribal member; wastewater surveillance; wastewater testing

Despite the abundance of clinical and epidemiologic data collected during this pandemic, relatively little focus has been paid to the examination of infectious agents through bulk wastewater detection and epidemiological data that is particularly well-suited for disease surveillance in remote, frontier settings such as the CRST Reservation. The goal of this application is to develop and implement a 15-community wastewater testing program for viral contaminants, including SARS-CoV-2, to better understand the utility of wastewater testing and COVID-19 or other viral outbreaks in this remote, low-resourced, and relatively low-density Tribal community. We will use our highly collaborative, multidisciplinary team of Native investigators to develop and implement, and evaluate the effectiveness of a viral wastewater sequencing testing program in a very rural and remote Northern Plains Lakota Reservation. Therefore, we propose to leverage our 20-year, long-running partnership with CRST to address the following Specific Aims: 1. Use a highly participatory approach to design, garner approval for, and implement a wastewater testing system in a large Tribal reservation community. This community surveillance approach will screen for viral isolates, including SARS-CoV-2, in coordination with CRST’s preexisting COVID-19 surveillance system; and 2. Deploy qualitative methods to examine 16 key Tribal stakeholders’ and Tribal members’ attitudes towards this new community wastewater testing approach and, ultimately, how this new environmental testing effort affects Tribal members socially, ethically, and behaviorally; and 3. Seek to codify this new resource into the Tribe’s public health emergency response program, thereby enhancing the Tribe’s capacity for future viral and other likely epidemic and pandemic outbreaks.

尽管在这次大流行期间收集了大量的临床和流行病学数据， 很少关注通过大量废水检测来检查传染性病原体， 流行病学数据，特别适合于偏远、边境地区的疾病监测 例如CRST保留区。 这个应用程序的目标是开发和实施一个15个社区的废水测试 针对包括SARS-CoV-2在内的病毒污染物的项目，以更好地了解废水的利用情况 在这个偏远、资源匮乏、人口密度相对较低的国家， 部落社区。 我们将利用我们高度合作的多学科土著调查员团队来开发和 实施，并评估病毒废水测序测试计划的有效性， 乡村和偏远的北方平原拉科塔保留地。 因此，我们建议利用我们与CRST长达20年的长期合作伙伴关系， 具体目标： 1.使用高度参与的方法来设计、获得批准和实施废水处理 测试系统在一个大型部落保留社区。这种社区监测方法将 与CRST先前存在的COVID-19协调，筛查病毒分离株，包括SARS-CoV-2 监察系统;及 2.部署定性方法，以检查16个关键的部落利益相关者和部落成员， 对这种新的社区废水测试方法的态度，以及最终， 新的环境测试工作在社会、道德和行为上影响部落成员; 3.寻求将这一新资源编入部落的公共卫生应急计划， 从而增强部落应对未来病毒和其他可能的流行病的能力 爆发