Assessment of pediatric immunotoxicity, public education, and capacity-building in communities impacted by PFAS-contaminated drinking water

评估受 PFAS 污染饮用水影响的社区的儿科免疫毒性、公共教育和能力建设

• 批准号: 10436901
• 负责人: Philip M Brown
• 金额: $ 51.5万
• 依托单位: SILENT SPRING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436901
• 关键词: Address; Adult; Affect; Age; American; Animals; Antibodies; Area; Attention; Back; Birth Weight; Blood Tests; Blood specimen; Carbon; Chemicals; Child; Child Health; Childhood; Cholesterol; Collaborations; Communities; Community Health Education; Complex; Complex Mixtures; Data; Data Analyses; Development; Diphtheria; Educational Materials; Environmental Health; Ethnography; Exposure to; Face; Family; Film; Fire - disasters; Goals; Government Agencies; Government Officials; Guidelines; Half-Life; Health; Human; Immune; Immune response; Immune system; Impairment; Individual; Inflammatory Response; Institutes; International; Interview; Knowledge; Life; Local Government; Malignant neoplasm of testis; Massachusetts; Medical; Methods; Military Personnel; Mission; National Toxicology Program; Nurses; Parents; Participant; Poly-fluoroalkyl substances; Public Health; Renal carcinoma; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Serum; Social Sciences; Source; Test Result; Testing; Tetanus; Toxic Actions; Toxic effect; Training; Universities; Vaccination; Water Supply; Woman; Work; aqueous; base; clinical risk; clinically relevant; community engaged research; community engagement; community involvement; community partnership; consumer product; contaminated drinking water; data exploration; data tools; digital; drinking water; education research; epidemiology study; experience; fighting; hazard; immune function; immunotoxicity; improved; inflammatory marker; innovation; malignant breast neoplasm; member; metabolomics; novel; online resource; outreach; programs; public education; remediation; reproductive; social; systematic review; tool; vaccine response; water testing; water treatment; web-based tool

A growing number of U.S. communities have discovered per- and polyfluoroalkyl substances (PFASs, often called PFCs) in drinking water. Epidemiological studies have reported negative associations between pediatric PFAS exposure and immune function, and suggest that current drinking water guidelines may not adequately protect children from immunotoxicity. In 2016, the National Toxicology Program concluded that two PFASs, PFOA and PFOS, are presumed immune hazards based on human and animal studies. A key knowledge gap is whether exposure to drinking water contaminated by AFFF firefighting foams with complex PFAS mixtures causes clinically relevant immunotoxicity. Communities seek guidance for interpreting blood and water test results and information on health effects, water treatment, remediation, and strategies to engage local officials. This project will leverage existing researcher-community partnerships to address concerns about health effects from PFASs in drinking water and develop tools and materials to support impacted communities. We will engage with two communities with AFFF-contaminated drinking water, the Pease International Tradeport in Portsmouth, NH, and Hyannis, MA, and evaluate potential immune responses and explore metabolomics profiles among young children. We will develop an online resource center to serve PFAS-affected communities nationwide with educational materials, data tools, and opportunities to connect with other communities. We will explore the exposure experience of affected communities by conducting in-depth interviews and ethnographic research. Project partners include environmental health and social science researchers and community activists with a well-established collaboration. This community-engaged research project has three aims: Aim 1. Quantify associations of child serum PFOA, PFOS, PFHxS, and total PFASs with a) serum antibody levels following diphtheria and tetanus (DTaP) vaccinations and b) metabolomic profiles. Aim 2. Develop the PFAS Exchange, an online resource center with educational materials, data interpretation tools, tap water testing, and resources to connect communities, provide report-back materials for participants, and engage with residents of affected communities, medical professionals, and other stakeholders. Aim 3. Assess individual, family, and community-level experience of residents in areas impacted by PFAS- contaminated drinking water. The proposed study is innovative in developing novel web-based tools to visualize and interpret personal exposure data, and will be the first to evaluate immunotoxicity and apply novel metabolomics methods in U.S. children exposed to AFFF-contaminated drinking water in early life. It will improve public health by supporting efforts to reduce exposures and health impacts of PFAS contamination through engagement, education, and research. This project fulfills the Research to Action mission by addressing community concerns about health effects of contaminated drinking water and involving community members throughout.

越来越多的美国社区发现了全氟烷基和多氟烷基物质（PFAS，通常 称之为PFCs）。流行病学研究已经报道了儿童和青少年之间的 PFAS暴露和免疫功能，并建议目前的饮用水指南可能不足以 保护儿童免受免疫毒性。2016年，国家毒理学计划得出结论，两种PFAS， 根据对人类和动物的研究，全氟辛酸和全氟辛烷磺酸被推定为免疫危害。关键的知识差距 是否暴露于被AFFF消防泡沫与复杂PFAS混合物污染的饮用水 引起临床相关的免疫毒性。社区寻求解释血液和水测试的指导 关于健康影响、水处理、补救措施和当地官员参与战略的结果和信息。 该项目将利用现有的研究人员-社区伙伴关系来解决对健康的关注 我们还将努力消除饮用水中PFASs的影响，并开发工具和材料，以支持受影响的社区。我们 将与两个饮用水受到AFFF污染的社区合作， 朴茨茅斯，NH和Hyannis，MA，并评估潜在的免疫反应和探索代谢组学 在幼儿中的形象。我们将开发一个在线资源中心，为受PFAS影响的社区提供服务 在全国范围内提供教育材料、数据工具和与其他社区联系的机会。我们将 通过进行深入访谈和人种学研究，探索受影响社区的接触经验 research.项目合作伙伴包括环境卫生和社会科学研究人员和社区 积极分子与良好的合作。这个社区参与的研究项目有三个目标： 目标1.量化儿童血清中全氟辛酸、全氟辛烷磺酸、全氟辛烷磺酸xS和全氟辛烷磺酸总量与a）血清抗体 白喉和破伤风（DTaP）疫苗接种后的水平和B）代谢组学特征。 目标2.开发PFAS交换，一个在线资源中心，提供教育材料，数据解释， 工具、自来水测试和资源，以连接社区，为参与者提供反馈材料， 并与受影响社区的居民、医疗专业人员和其他利益相关者进行接触。 目标3.评估受PFAS影响地区居民的个人、家庭和社区层面的经验- 被污染的饮用水。 这项研究在开发新颖的基于网络的工具来可视化和解释个人信息方面具有创新性。 暴露数据，并将是第一个评估免疫毒性和应用新的代谢组学方法在美国。 在生命早期暴露于AFFF污染的饮用水的儿童。它将通过支持改善公共卫生 努力通过参与、教育和 research.该项目通过解决社区对健康的关注来实现从研究到行动的使命 受污染的饮用水的影响，并涉及整个社区成员。

项目成果

Per- and Polyfluoroalkyl Substances (PFAS) in Facemasks: Potential Source of Human Exposure to PFAS with Implications for Disposal to Landfills.

• DOI: 10.1021/acs.estlett.2c00019
• 发表时间: 2022-03
• 期刊: Environmental science & technology letters
• 影响因子: 10.9
• 作者: Derek J Muensterman;Liliana Cahuas;Ivan A. Titaley;Christopher Schmokel;Florentino B. De la Cruz;M. Barlaz;Courtney C. Carignan;G. Peaslee;J. Field

Invited Perspective: Examining Chemicals in Food as a Priority for Toxicity Testing.

• DOI: 10.1289/ehp12630
• 发表时间: 2023-03
• 期刊: Environmental health perspectives
• 影响因子: 10.4

Self-Collection Blood Test for PFASs: Comparing Volumetric Microsamplers with a Traditional Serum Approach.

• DOI: 10.1021/acs.est.2c09852
• 发表时间: 2023-05-30
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Carignan, Courtney C.;Bauer, Rachel A.;Patterson, Andrew;Phomsopha, Thep;Redman, Eric;Stapleton, Heather M.;Higgins, Christopher P.
• 通讯作者: Higgins, Christopher P.

Environmental chemicals and public sociology: engaged scholarship on highly fluorinated compounds

• DOI: 10.1080/23251042.2019.1629271
• 发表时间: 2019-06-23
• 期刊: ENVIRONMENTAL SOCIOLOGY
• 影响因子: 2.5
• 作者: Cordner, Alissa;Richter, Lauren;Brown, Phil
• 通讯作者: Brown, Phil