Assessment of pediatric immunotoxicity, public education, and capacity-building in communities impacted by PFAS-contaminated drinking water

评估受 PFAS 污染饮用水影响的社区的儿科免疫毒性、公共教育和能力建设

• 批准号: 10215529
• 负责人: Philip M Brown
• 金额: $ 51.24万
• 依托单位: SILENT SPRING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215529
• 关键词: Address; Adult; Affect; Age; American; Animals; Antibodies; Area; Attention; Back; Birth Weight; Blood Tests; Blood specimen; Carbon; Chemicals; Child; Child Health; Childhood; Cholesterol; Collaborations; Communities; Community Health Education; Complex; Complex Mixtures; Data; Data Analyses; Development; Diphtheria; Educational Materials; Environmental Health; Ethnography; Exposure to; Face; Family; Film; Fire - disasters; Goals; Government Agencies; Government Officials; Guidelines; Half-Life; Health; Human; Immune; Immune response; Immune system; Impairment; Individual; Inflammatory Response; Institutes; International; Interview; Knowledge; Life; Local Government; Malignant neoplasm of testis; Massachusetts; Medical; Methods; Military Personnel; Mission; National Toxicology Program; Nurses; Parents; Participant; Public Health; Renal carcinoma; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Serum; Social Sciences; Source; Test Result; Testing; Tetanus; Toxic Actions; Toxic effect; Training; Universities; Vaccination; Water Supply; Woman; Work; aqueous; base; clinical risk; clinically relevant; community engaged research; community engagement; community involvement; community partnership; consumer product; contaminated drinking water; data exploration; data tools; digital; drinking water; education research; epidemiology study; experience; fighting; hazard; immune function; immunotoxicity; improved; inflammatory marker; innovation; malignant breast neoplasm; member; metabolomics; novel; online resource; outreach; programs; public education; remediation; reproductive; social; systematic review; tool; vaccine response; water testing; water treatment; web-based tool

A growing number of U.S. communities have discovered per- and polyfluoroalkyl substances (PFASs, often called PFCs) in drinking water. Epidemiological studies have reported negative associations between pediatric PFAS exposure and immune function, and suggest that current drinking water guidelines may not adequately protect children from immunotoxicity. In 2016, the National Toxicology Program concluded that two PFASs, PFOA and PFOS, are presumed immune hazards based on human and animal studies. A key knowledge gap is whether exposure to drinking water contaminated by AFFF firefighting foams with complex PFAS mixtures causes clinically relevant immunotoxicity. Communities seek guidance for interpreting blood and water test results and information on health effects, water treatment, remediation, and strategies to engage local officials. This project will leverage existing researcher-community partnerships to address concerns about health effects from PFASs in drinking water and develop tools and materials to support impacted communities. We will engage with two communities with AFFF-contaminated drinking water, the Pease International Tradeport in Portsmouth, NH, and Hyannis, MA, and evaluate potential immune responses and explore metabolomics profiles among young children. We will develop an online resource center to serve PFAS-affected communities nationwide with educational materials, data tools, and opportunities to connect with other communities. We will explore the exposure experience of affected communities by conducting in-depth interviews and ethnographic research. Project partners include environmental health and social science researchers and community activists with a well-established collaboration. This community-engaged research project has three aims: Aim 1. Quantify associations of child serum PFOA, PFOS, PFHxS, and total PFASs with a) serum antibody levels following diphtheria and tetanus (DTaP) vaccinations and b) metabolomic profiles. Aim 2. Develop the PFAS Exchange, an online resource center with educational materials, data interpretation tools, tap water testing, and resources to connect communities, provide report-back materials for participants, and engage with residents of affected communities, medical professionals, and other stakeholders. Aim 3. Assess individual, family, and community-level experience of residents in areas impacted by PFAS- contaminated drinking water. The proposed study is innovative in developing novel web-based tools to visualize and interpret personal exposure data, and will be the first to evaluate immunotoxicity and apply novel metabolomics methods in U.S. children exposed to AFFF-contaminated drinking water in early life. It will improve public health by supporting efforts to reduce exposures and health impacts of PFAS contamination through engagement, education, and research. This project fulfills the Research to Action mission by addressing community concerns about health effects of contaminated drinking water and involving community members throughout.

越来越多的美国社区发现了人类和多氟烷基物质（PFASS，通常 在饮用水中称为pfcs）。流行病学研究报告了小儿之间的负相关 PFAS暴露和免疫功能，并建议目前的饮用水指南可能无法充分 保护儿童免疫毒性。 2016年，国家毒理学计划得出结论，两个PFAS， PFOA和PFO是基于人类和动物研究的假定免疫危害。关键知识差距 是否暴露于AFFF消防泡沫污染的饮用水中是否具有复杂的PFAS混合物 引起临床相关的免疫毒性。社区寻求指导来解释血液和水测试 结果和有关健康影响，水处理，补救和与当地官员互动的策略的信息。 该项目将利用现有的研究人员社区合作伙伴关系来解决对健康的担忧 PFAS在饮用水中的影响以及开发工具和材料以支持受影响的社区。我们 将与两个社区与AFFF污染的饮用水互动，Pease International Tradeport 新罕布什尔州朴次茅斯和马萨诸塞州的海安尼斯，并评估潜在的免疫反应并探索代谢组学 幼儿的个人资料。我们将开发一个在线资源中心，以服务于受PFA受PFA的社区 在全国范围内拥有教育材料，数据工具和与其他社区建立联系的机会。我们将 通过进行深入的访谈和人种学探索受影响社区的曝光经历 研究。项目合作伙伴包括环境健康和社会科学研究人员和社区 积极的合作者。这个由社区参与的研究项目具有三个目的： AIM 1。量化儿童血清PFOA，PFO，PFHXS和Total PFASS的关联与A）血清抗体 白喉和破伤风（DTAP）疫苗接种和b）代谢组谱后的水平。 目标2。开发PFAS Exchange，这是一个在线资源中心，具有教育材料，数据解释 工具，自来水测试和连接社区的资源，为参与者提供报告背包材料， 并与受影响社区，医疗专业人员和其他利益相关者的居民互动。 AIM 3。评估居民在受PFAS的影响的地区的个人，家庭和社区级别的经验 受污染的饮用水。 拟议的研究在开发基于Web的新型工具方面具有创新性来可视化和解释个人 暴露数据，将是第一个评估免疫毒性并在美国应用新型代谢组学方法的人 在早期，儿童暴露于AFFF污染的饮用水中。它将通过支持来改善公共卫生 通过参与，教育和 研究。该项目通过解决社区对健康的担忧来履行行动任务 受污染的饮用水和整个社区成员的影响。