Assessment of pediatric immunotoxicity, public education, and capacity-building in communities impacted by PFAS-contaminated drinking water

评估受 PFAS 污染饮用水影响的社区的儿科免疫毒性、公共教育和能力建设

• 批准号: 10215529
• 负责人: Philip M Brown
• 金额: $ 51.24万
• 依托单位: SILENT SPRING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215529
• 关键词: Address; Adult; Affect; Age; American; Animals; Antibodies; Area; Attention; Back; Birth Weight; Blood Tests; Blood specimen; Carbon; Chemicals; Child; Child Health; Childhood; Cholesterol; Collaborations; Communities; Community Health Education; Complex; Complex Mixtures; Data; Data Analyses; Development; Diphtheria; Educational Materials; Environmental Health; Ethnography; Exposure to; Face; Family; Film; Fire - disasters; Goals; Government Agencies; Government Officials; Guidelines; Half-Life; Health; Human; Immune; Immune response; Immune system; Impairment; Individual; Inflammatory Response; Institutes; International; Interview; Knowledge; Life; Local Government; Malignant neoplasm of testis; Massachusetts; Medical; Methods; Military Personnel; Mission; National Toxicology Program; Nurses; Parents; Participant; Public Health; Renal carcinoma; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Serum; Social Sciences; Source; Test Result; Testing; Tetanus; Toxic Actions; Toxic effect; Training; Universities; Vaccination; Water Supply; Woman; Work; aqueous; base; clinical risk; clinically relevant; community engaged research; community engagement; community involvement; community partnership; consumer product; contaminated drinking water; data exploration; data tools; digital; drinking water; education research; epidemiology study; experience; fighting; hazard; immune function; immunotoxicity; improved; inflammatory marker; innovation; malignant breast neoplasm; member; metabolomics; novel; online resource; outreach; programs; public education; remediation; reproductive; social; systematic review; tool; vaccine response; water testing; water treatment; web-based tool

A growing number of U.S. communities have discovered per- and polyfluoroalkyl substances (PFASs, often called PFCs) in drinking water. Epidemiological studies have reported negative associations between pediatric PFAS exposure and immune function, and suggest that current drinking water guidelines may not adequately protect children from immunotoxicity. In 2016, the National Toxicology Program concluded that two PFASs, PFOA and PFOS, are presumed immune hazards based on human and animal studies. A key knowledge gap is whether exposure to drinking water contaminated by AFFF firefighting foams with complex PFAS mixtures causes clinically relevant immunotoxicity. Communities seek guidance for interpreting blood and water test results and information on health effects, water treatment, remediation, and strategies to engage local officials. This project will leverage existing researcher-community partnerships to address concerns about health effects from PFASs in drinking water and develop tools and materials to support impacted communities. We will engage with two communities with AFFF-contaminated drinking water, the Pease International Tradeport in Portsmouth, NH, and Hyannis, MA, and evaluate potential immune responses and explore metabolomics profiles among young children. We will develop an online resource center to serve PFAS-affected communities nationwide with educational materials, data tools, and opportunities to connect with other communities. We will explore the exposure experience of affected communities by conducting in-depth interviews and ethnographic research. Project partners include environmental health and social science researchers and community activists with a well-established collaboration. This community-engaged research project has three aims: Aim 1. Quantify associations of child serum PFOA, PFOS, PFHxS, and total PFASs with a) serum antibody levels following diphtheria and tetanus (DTaP) vaccinations and b) metabolomic profiles. Aim 2. Develop the PFAS Exchange, an online resource center with educational materials, data interpretation tools, tap water testing, and resources to connect communities, provide report-back materials for participants, and engage with residents of affected communities, medical professionals, and other stakeholders. Aim 3. Assess individual, family, and community-level experience of residents in areas impacted by PFAS- contaminated drinking water. The proposed study is innovative in developing novel web-based tools to visualize and interpret personal exposure data, and will be the first to evaluate immunotoxicity and apply novel metabolomics methods in U.S. children exposed to AFFF-contaminated drinking water in early life. It will improve public health by supporting efforts to reduce exposures and health impacts of PFAS contamination through engagement, education, and research. This project fulfills the Research to Action mission by addressing community concerns about health effects of contaminated drinking water and involving community members throughout.

越来越多的美国社区经常发现全氟烷基和多氟烷基物质（PFASs）