Neural basis of vocal signal recognition during natural communication

自然交流过程中声音信号识别的神经基础

• 批准号: 10437642
• 负责人: CORY T MILLER
• 金额: $ 33.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437642
• 关键词: Acoustics; Address; Adult; Anatomy; Area; Auditory; Auditory area; Auditory system; Behavior; Brain; Callithrix; Characteristics; Chronic; Communication; Computer software; Data; Dependovirus; Disease; Environment; Face; Feedback; Female; Foundations; Functional Magnetic Resonance Imaging; Human; Human Characteristics; Individual; Interneurons; Laboratories; Language; Macaca mulatta; Maps; Measures; Methods; Modeling; Molecular; Neocortex; Neurologic; Neurons; Pathway interactions; Pattern; Play; Population; Preparation; Primates; Process; Property; Pyramidal Cells; Recombinant adeno-associated virus (rAAV); Role; Sex Differences; Signal Transduction; Societies; Speech; Stimulus; Structure; System; Techniques; Testing; Voice; auditory pathway; awake; base; cell type; communication behavior; experimental study; extrastriate visual cortex; frontal lobe; innovation; male; neural circuit; neuroimaging; neuromechanism; neurophysiology; nonhuman primate; novel; optogenetics; promoter; relating to nervous system; response; signal processing; social; sound; tool; virtual; vocalization

Project Summary Communication is an inherently interactive process involving the exchange of information between individuals. For communication to occur, individuals must both recognize the sound as a social signal (e.g. vocalizations), rather than another sound in the environment, as well as the relevant information encoded within the structure of the signal, such as the caller's identity. Despite the relative ease with which the primate auditory system is able to perform these computations, and evidence of vocal signal processing in primate cortex, relatively is known about the neural mechanisms underlying recognition of these communication signals. The primary aim of this proposal is to investigate the complementary roles of auditory and frontal cortex for vocal signal recognition during natural communication. To investigate this process, we employ a multi-technique approach aimed at elucidating the mechanisms underlying vocal signal recognition throughout the ventral auditory cortical system during marmoset antiphonal conversations. Aim 1 utilizes neuroimaging (fMRI) to identify vocalization responsive populations in the auditory and frontal cortex in awake subjects. The primary aim here is to test whether particular areas of these substrates in the cortical auditory system and will serve as a foundation for subsequent experiments in the proposal. Aim 2 builds on these findings to record the neurophysiological characteristics of neurons in auditory and frontal cortex while freely-moving marmosets engage in their naturally occurring antiphonal conversations. We employ a novel interactive playback paradigm in which subjects directly engage in these vocal interactions with a software-generated `Virtual Marmoset' (VM). Because the vocal behavior and signals of the VM can be experimentally manipulated, we will use this paradigm to test the responses of neurons throughout these substrates for call recognition and social recognition. Aim 3 utilizes optogenetic techniques to explicitly test the functional contributions of auditory cortex for vocal signal recognition. We employ a novel, chronic optogenetic preparation developed in my laboratory for marmosets to selectively photostimulate primary auditory cortex and the rostral belt region during antiphonal conversations. Subjects will engage in the same VM paradigms used in Aim 2 during these experiments to test the respective functional contributions of these substrates on call and social recognition during natural communication.

项目摘要 沟通是一个内在的互动过程，涉及个人之间的信息交换。 为了进行交流，个体必须将声音识别为社会信号（例如发声）， 而不是环境中的另一种声音，以及结构中编码的相关信息 例如呼叫者的身份。尽管灵长类动物的听觉系统相对容易 能够执行这些计算，以及灵长类动物皮层中声音信号处理的证据，相对来说， 我们对这些通信信号的神经识别机制知之甚少。主要目的 本研究的主要目的是探讨听觉皮层和额叶皮层对声音信号的互补作用 自然沟通中的认知。为了研究这一过程，我们采用了多技术方法 旨在阐明整个腹侧听觉系统中声音信号识别的机制， 在绒猴对唱对话中的皮层系统。目的1利用神经成像（fMRI）来识别 清醒受试者的听觉和额叶皮层中的发声反应群体。这里的主要目的 是为了测试这些基质在皮层听觉系统中的特定区域是否会作为一个 为以后的实验打下基础。目标2以这些发现为基础， 自由活动状态下绒猴听觉和额叶皮层神经元的神经生理特征 参与他们自然发生的对唱对话。我们采用了一种新颖的交互式回放 一种范例，在这种范例中，受试者直接参与这些与软件生成的“虚拟 绒猴'（VM）。因为VM的发声行为和信号可以通过实验来操纵，我们 将使用这种范式来测试神经元在这些基底上对呼叫识别的反应， 社会认可。目的3利用光遗传学技术明确测试听觉的功能贡献， 声音信号识别的皮层。我们使用了一种新的，慢性光遗传学制剂， 实验室的绒猴选择性光刺激初级听觉皮层和喙带区域， 对唱的对话受试者将参与目标2中使用的相同VM范例， 实验来测试这些底物对呼叫和社会识别的各自功能贡献 在自然沟通中。