Neural basis of vocal signal recognition during natural communication

自然交流过程中声音信号识别的神经基础

• 批准号: 8500226
• 负责人: CORY T MILLER
• 金额: $ 35.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8500226
• 关键词: Acoustics; Address; Affect; Animals; Auditory; Auditory area; Auditory system; Behavior; Behavioral; Callithrix; Callithrix jacchus jacchus; Categories; Clinical Treatment; Cognitive; Communication; Complex; Computer software; Cues; Data; Dimensions; Disease; Dorsal; Environment; Foundations; Future; Histology; Human; Individual; Language; Location; Modeling; Neocortex; Neuroanatomy; Neurologic; Neurons; Patients; Perception; Physiology; Play; Prefrontal Cortex; Primates; Process; Property; Role; Sampling; Series; Signal Transduction; Site; Speech; Stimulus; Structure; System; Techniques; Testing; Voice; Work; base; communication behavior; frontal lobe; innovation; neural patterning; neuroimaging; neuromechanism; neurophysiology; nonhuman primate; novel; relating to nervous system; research study; response; sex; social; sound; speech recognition; vocalization

DESCRIPTION (provided by applicant): Human and nonhuman primates communicate with conspecifics using vocalizations. For communication in this medium to be successful, listeners must be able to recognize vocal signals (e.g. words for humans) and parse them from the plethora of other biotic and abiotic sounds in the acoustic environment. Rather than be the culmination of vocal signal recognition, identifying species-specific acoustic signals is only one part of a more complex process. Like other objects, vocal signals comprise a number of categories that reflect social dimensions of the caller, such as individual identity, sex, dialect, etc. These social categories are encoded in the acoustic structure of the vocalization due to idiosyncrasies in the caller's voice and are known to be perceptually meaningful in both human and nonhuman primate vocal interactions. While the neural basis of speech recognition has been extensively studied using various neuroimaging techniques and patients, much less is known about its underlying cellular mechanisms. Given similarities in vocal perception and homologies in the auditory system neuroanatomy, nonhuman primates represent an excellent model for explicating the neural mechanisms underlying vocal signal recognition in primate neocortex. Nearly all earlier neural studies of vocalization processing in nonhuman primate cortex involve experiments in which vocalization exemplars are presented to restrained animals. Communication, however, is an inherently interactive process involving the exchange of signals between conspecifics. The aim of this proposal is to examine vocal signal recognition in naturally behaving common marmosets while they engage in antiphonal calling, a vocal behavior characterized by the reciprocal exchange of vocalizations. Since marmosets will only produce an antiphonal call in response to a particular call type, this behavior represents a natural (i.e. untrained) recognition system and is uniquely suited to explore the neural basis of social categorization during natural communication for the following three reasons. First, previous work shows that social categories of callers affect the dynamics of antiphonal calling. Second, we developed novel, interactive playback software that allows us to elicit this vocal response under experimental conditions. And third, we can record the activity of single neurons in marmoset prefrontal cortex while subjects are freely-moving. These three components represent a potentially powerful approach to addressing the three aims of this proposal. Specific Aim 1 is to combine single-unit neurophysiology and histology to characterize the functional neuroanatomy of marmoset frontal cortex for vocal communication. This aim will establish a foundation for all subsequent physiology, both in this proposal and further in the future. Specific Aim 2 seeks to extensively test the perceptual basis of social categorization by presenting subjects with synthetically manipulated vocalizations. Specific Aim 3 builds on the preceding aims of this proposal by testing the neural basis of social categorization during antiphonal calling using the neuroanatomical locations of Aim 1 and the perceptual findings of Aim 2.

描述（由申请人提供）：人类和非人类灵长类动物通过发声与同种动物交流。为了在这种媒介中成功交流，听众必须能够识别声音信号（例如人类的单词），并从声学环境中的大量其他生物和非生物声音中解析它们。识别特定物种的声音信号只是一个更复杂过程的一部分，而不是声音信号识别的高潮。与其他物体一样，声音信号也包含许多类别，这些类别反映了呼叫者的社会层面，如个人身份、性别、方言、