Predoctoral Training Program in Quantitative Mechanobiology

定量力学生物学博士前培训项目

• 批准号: 10439646
• 负责人: Beth L Pruitt
• 金额: $ 30.37万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10439646
• 关键词: Training Programs; pre-doctoral

Project Summary/Abstract This application seeks funding for a new Interdisciplinary Predoctoral Training Program in Quantitative Mechanobiology at University of California, Santa Barbara (UCSB). The Program brings biologists, physicists, and engineers together to pursue fundamental understanding of the biophysical principles underlying human health spanning molecular to organismal level processes of mechanosignaling in development, homeostasis and disease. The focus of this initiative is cross-disciplinary training in mechanobiology, i.e., relationships between physical forces and biological structure and function, to produce a new cadre of bioscientists who will develop quantitative solutions to biology’s most challenging problems. If funded, the Training Program in Quantitative Mechanobiology will be UCSB’s first training grant and will serve as a flagship predoctoral training program that nucleates a connected community across the many labs already conducting mechanobiology research at UCSB through peer-to-peer interactions, cross-lab training, seminars, courses, and an annual symposium/retreat. The Program will provide support for Fellows to undertake three research rotations in their first year and opportunities for unique cross-training in mechanobiology. Each year, six Mechanobiology Fellows will be admitted with a steady state Program size of twelve predoctoral training slots. The Program will recruit and support Fellows from six graduate degree programs and augment their PhD programs with training in quantitative bioscience methods, engineering models and devices, and multi-disciplinary cross-training to develop and apply quantitative approaches to problems in mechanobiology. To provide optimal interdisciplinary mentorship and research training experiences, each Fellow will work with their project PI and will also be assigned a Program Mentor with complementary seniority, quantitative, experimental, and analytical approaches. The Program Mentor will also serve on the Fellow’s dissertation committee. This chain of mentorship is supported by formal Mentor trainings and leverages our mix of junior and senior Faculty Mentors to support both our Fellows and our junior Faculty Mentors. Fellows will benefit from formalized interactions with the diverse community of faculty and peers, as well as resources, associated with Program and affiliated graduate programs. Key components of the Program include formalized training in Responsible Conduct of Research, Quantitative Experiments, didactic and hands-on training in methods and analytical techniques in a Mechanobiology Methods course and quarterly “open door” lab sessions in Faculty Mentor labs. The Program will feature monthly seminars with peers, visiting researchers, and Faculty Mentors as well as career development activities, and an annual symposium/retreat uniting the entire UCSB mechanobiology community. Trainees from diverse disciplines, backgrounds, and groups will be prepared to lead rigorous biomedical research programs and promote scientific advances in academia, industry, national labs, and technology and policy careers.

项目摘要/摘要 本申请寻求为新的跨学科博士前培训计划提供资金 加州大学圣巴巴拉分校(UCSB)机械生物学专业。该计划带来了生物学家、物理学家、 和工程师一起寻求对人类潜在的生物物理原理的基本理解 从分子水平到生物体水平的发育、内稳态机械信号传递过程的健康 和疾病。这一倡议的重点是机械生物学的跨学科培训，即人际关系 在物理力量和生物结构和功能之间，产生一支新的生物科学家队伍 为生物学中最具挑战性的问题制定量化解决方案。如果获得资金，培训计划将在 定量机械生物学将是UCSB的第一笔培训赠款，并将作为旗舰博士前培训 在已经进行机械生物学的许多实验室中形成一个相互联系的社区的计划 UCSB通过点对点互动、跨实验室培训、研讨会、课程和年度 座谈会/务虚会。该方案将为研究员提供支持，以便在他们的工作中进行三次研究轮换 第一年和在机械生物学方面进行独特交叉训练的机会。每年，六个机械生物学 研究员将以12个博士前培训时段的稳定状态计划规模被录取。该计划将 招聘和支持六个研究生学位项目的研究员，并通过培训增强他们的博士项目 在定量生物科学方法、工程模型和设备以及多学科交叉培训方面 开发和应用定量方法来解决机械生物学中的问题。提供最佳的跨学科 导师和研究培训经验，每个研究员都将与他们的项目PI合作，也将 指派了一位资历互补的项目导师，负责定量、实验和分析 接近了。该项目导师还将在该研究员的论文委员会任职。这条链条 导师制得到正式导师培训的支持，并利用我们初级和高级教师导师的组合 以支持我们的研究员和我们的初级教师导师。研究员将从正式的互动中受益 拥有不同的教职员工和同行社区，以及与计划和附属机构相关的资源 研究生课程。该方案的主要组成部分包括正式的负责任行为培训 方法和分析技术方面的研究、定量实验、教学和实践培训 机械生物学方法课程和教师导师实验室的每季度“开放”实验室会议。该计划 将每月与同行、访问研究人员和教师导师以及职业生涯举行研讨会 发展活动，以及团结整个UCSB机械生物学社区的年度研讨会/务虚会。 来自不同学科、背景和团体的学员将准备好领导严格的生物医学 研究计划和促进学术界、工业界、国家实验室和技术以及 政策性职业。