Quantitative Science Shared Resource

定量科学共享资源(QSSR)项目综述 从癌症中心成立之初，量化科学共享资源一直是 为癌症中心提供支撑和增值的支持。今天也是如此，尽管需求和 解决方案已经演变。目前，作为丹·L邓肯癌症中心内的矩阵共享资源(SR) 和贝勒医学院的先进技术核心--量化科学共享资源 (QSSR)继续发挥关键作用。资源，最初的标题是生物统计和信息学共享 资源(BISR)，最初是作为2006年第一个CCSG应用程序的一部分建立的。为应对变化 根据需求，我们已将SR和重组后的服务与协作支持重新命名，以专注于生物统计， 生物信息学和我们的高性能计算(HPC)集群形式的计算基础设施。 共享资源的具体目标包括： 目标1.为临床、翻译和基础知识提供最先进的设计、实施、分析和解释 通过生物统计学、生物信息学和多组学方法进行与癌症相关的科学研究； 目标2.提供获得高质量、专业管理的高性能计算的途径； 目标3.与其他面向高吞吐量的共享资源就其分析和数据进行协调 管理需求； 目标4.协助DLDCCC进行教育和培训、科学审查、数据监测和战略 计划。 QSSR是癌症中心的关键资源。在过去的4年里，我们几乎每一次 癌症中心努力的方面-从基础研究到临床研究，与 其他共享资源、科学审查和教育。尽管已经过渡到作为BCM的管理- 宽矩阵SR，我们继续有非常高水平的癌症焦点。我们在领导层有很好的代表性 癌症中心级别，QSSR领导人在多个委员会任职，包括执行委员会 委员会审议阶段。我们处于有利地位，可以就战略举措的量化方面向DLDCCC提供建议，并 应对新的或不断变化的优先事项。在上一次融资期间，我们继续战略增长，并补充说 根据我们最初和随后提出的计划，提供教职员工和重组服务 申请，并根据监督和咨询委员会以及癌症中心领导层的建议。未来计划 包括招聘更多教职员工，促进更好地利用高性能计算， 为面向技术的高吞吐量共享资源提供改进的数据管理和 分析管道。

PROJECT SUMMARY: Quantitative Science Shared Resource (QSSR) Quantitative science shared resources have been, from the beginning of cancer centers, a centerpiece of the support that underpins and adds value to a cancer center. The same holds true today, although needs and solutions have evolved. At present, as a matrix Shared Resource (SR) within the Dan L Duncan Cancer Center and the Advanced Technology Cores of Baylor College of Medicine, the Quantitative Science Shared Resource (QSSR) continues to play a critical role. The Resource, originally titled Biostatistics and Informatics Shared Resource (BISR), was initially established as part of the first CCSG application in 2006. In response to changing needs, we have renamed the SR and restructured services and collaborative support to focus on biostatistics, bioinformatics, and computational infrastructure in the form of our High Performance Compute (HPC) cluster. Specific Aims of the Shared Resource include: Aim 1. To provide state-of-the-art design, conduct, analysis, and interpretation to clinical, translational, and basic science cancer-related research through biostatistical, bioinformatic, and multi-omic methods; Aim 2. To provide access to high quality, professionally managed high performance computing; Aim 3. To coordinate with other high-throughput oriented Shared Resources on their analytic and data management needs; Aim 4. To assist the DLDCCC with education and training, scientific review, data monitoring, and strategic planning. The QSSR is a critical resource to the Cancer Center. During the last 4 years we contributed to virtually every aspect of Cancer Center endeavor – ranging from basic through clinical research, coordination of data flows with other shared resources, scientific review, and education. Despite having transitioned to management as a BCM- wide matrix SR, we continue to have a very high level of cancer focus. We are well represented at the leadership level of the Cancer Center, where QSSR leaders serve on a number of committees, including the Executive Committee. We are well-positioned to advise the DLDCCC on quantitative aspects of strategic initiatives and to respond to new or changing priorities. During the last funding period, we continued to grow strategically, adding faculty, staff and restructuring services, according to the plans put forward in our initial and subsequent applications, and on advice of oversight and advisory committees, and Cancer Center leadership. Future plans include additional faculty and staff recruitment, promoting enhanced access to High Performance Computing, and assisting high-throughput technology-oriented shared-resources with improved data management and analysis pipelines.