Biostatistics and Data Management

这是一个现有的、运作良好的和绝对必要的核心的延续。前一 在资助期间，核心为所有五个项目提供了广泛的生物统计和数据管理支持， 病理学核心和肿瘤库核心，以及几个发展项目， 共同撰写了30多篇出版物，其中许多发表在高影响力的期刊上。所有项目在我们的新 SPORE应用程序将需要大量的临床前和临床统计支持 实验根据我们的经验，集中的生物统计支持可确保生物统计学家 完全熟悉项目和核心的各个方面。这提供了连续性，提高了效率， 并确保采用适当的方法。核心B（生物统计和数据）的具体目标 管理）是：（1）提供全面的生物统计学和生物信息学咨询，数据分析， （2）为临床试验的开展和分析提供全面支持，包括数据 质量控制和监测、中期监测和数据分析、最终分析和报告;（3） 开发和维护数据库和数据库应用程序，以支持项目和核心。孢子 拥有一个专业、经验丰富、具备各种技能的分析师团队，将大大受益。为 例如，微阵列实验的分析是特别苛刻和复杂的， 生物统计学和生物信息学专业知识。核心分析师是SPORE各个方面的积极参与者。 所有项目的样本量考虑、实验设计和计划分析概述如下： 与核心小组合作编写，并在每个项目和具体目标中提供。此外，本发明还提供了一种方法， 对项目和核心数据和分析需求的深入理解反过来又推动了数据库开发， 确保数据库解决方案满足SPORE的广泛和特定项目的需求。核心 研究人员还可以帮助研究人员设计新的研究，并测试可能出现的新假设， 这些相关项目的相互促进。最后，核心领导者是经验丰富的生物统计学家，他们 与所有SPORE调查人员和其他核心领导者有长期的合作关系，以及谁 是Dan L.的生物统计学共享资源的成员。贝勒大学邓肯癌症中心 医学，从而促进与癌症中心的密切结合。

This is a continuation of an existing, well-functioning and absolutely essential Core. During the previous funding period, the Core provided extensive biostatistical and data management support to all five projects, to both the Pathology Core and the Tumor Bank Core, and to several of the Developmental Projects, resulting in more than 30 coauthored publications, many in high impact journals. All projects in our new SPORE application will require substantial statistical support for a range of preclinical and clinical experiments. In our experience, centralized biostatistical support ensures that the biostatisticians are completely familiar with all aspects of the Projects and Cores. This provides continuity, increases efficiency, and ensures that appropriate methods are applied. The specific aims of the Core B (Biostatistics and Data Management) are to: (1) Provide comprehensive biostatistical and bioinformatical consultation, data analysis and reporting; (2) Provide comprehensive support for conduct and analysis of clinical trials, including data quality control and monitoring, interim monitoring and analysis of data, final analysis, and reporting; (3) Develop and maintain databases and database applications in support of Projects and Cores. The SPORE benefits greatly from having a dedicated and experienced team of analysts with a range of skills. For example, analysis of microarray experiments is especially demanding and complex and will require both biostatistical and bioinformatic expertise. Core analysts are active participants in all aspects of the SPORE. Sample size considerations, experimental designs, and overviews of planned analyses for all projects were prepared in collaboration with the Core, and are provided within each project and specific aim. In addition, deep understanding of Project and Core data and analysis needs, in turn, drives database development, ensuring that database solutions meet the broad as well as project-specific needs of the SPORE. Core personnel can also help the investigators design new studies and test new hypotheses that may arise by cross-fertilization of these related projects. Finally, Core leaders are highly experienced biostatisticians, who have longstanding collaborative relationships with all SPORE investigators and other Core leaders, and who are members of the Biostatistics Shared Resource of the Dan L. Duncan Cancer Center at Baylor College of Medicine, thus facilitating a close integration with the Cancer Center.