BIOSTATISTICS AND INFORMATICS

从癌症中心成立之初，生物统计共享资源就一直是支撑和增加癌症中心价值的基础设施的核心。这在今天也是如此，尽管需求在继续发展。目前，在丹·L邓肯癌症中心内，生物统计和信息学共享资源发挥着关键作用，展望下一个资助期，我们提出的改革和战略增强将继续为癌症中心的研究提供尽可能好的支持。该资源最初是作为2006年第一个CCSG申请的一部分设立的。《资源》 主要是从乳房中心生物统计小组的现有能力和人员中成长起来的。在苏珊·希尔森贝克博士的指导下，这个小组已经与非乳房中心的研究人员建立了强有力的赠款资助合作关系，合作范围包括现在的癌症细胞和基因治疗计划、核受体计划和癌症预防和人口科学计划，以及乳房计划的广泛研究人员。在我们的第一个资助期内，我们继续战略性地增长，根据我们最初申请中提出的计划，增加了教师、工作人员和服务，并满足了癌症中心的需求。我们首先增加了教职员工，以增加对生物信息学分析的支持。我们扩大了支持临床试验的专业知识，现在，在这场竞争的更新中，我们提议通过纳入癌症中心正在开发的信息学小组，正式增加对其他类型信息学的支持。该资源的主要目的是通过在临床和基础科学研究的设计、实施、分析和解释的生物统计学和信息学方面的合作，支持癌症中心投资者的研究努力。这将通过提供生物统计和生物信息学援助(一般咨询、实验设计、协助进行临床试验、统计分析、方法开发和解释)；信息学支持(项目管理、信息技术/硬件管理和数据库开发，包括caBlG整合)；对可持续发展战略以及教育和培训进行统计审查来实现。未来的计划包括增加教职员工 通过改进数据管理和分析管道，招聘、开发更好的临床数据管理和报告系统，以及协助高通量面向技术的共享资源，如集成显微镜SR或新的全基因组RNAi筛选和分析SR。

Biostatistics shared resources have, from the beginning of cancer centers, been a centerpiece of the infrastructure that underpins and adds value to a cancer center. The same holds true today, although needs continue to evolve. At present, within the Dan L Duncan Cancer Center, the Biostatistics and Informatics Shared Resource plays a critical role, and going forward into the next funding period, we propose changes and strategic enhancements that will continue to provide the best possible support of research at the Cancer Center. The resource was initially established as part of the first CCSG application in 2006. The Resource grew, primarily, out of existing capabilities and personnel in the biostatistics group in the Breast Center. Directed by Dr. Susan Hilsenbeck, this group had already established strong grant-funded collaborations with non-Breast Center investigators in what is now the Cancer Cell and Gene Therapy Program, the Nuclear Receptors Program, and the Cancer Prevention and Population Science Program, as well as a broad spectrum of investigators in the Breast Program. During our first funding period we continued to grow strategically, adding faculty, staff and services, according to the plan put forward in our initial application, and to address Cancer Center needs. We first added faculty and staff to increase support for bioinformatic analyses. We expanded expertise to support clinical trials, and now, in this competing renewal, propose to formally add support for other kinds of informatics by inclusion of the Cancer Center's developing informatics group. The primary purpose of the Resource is to support the research efforts of Cancer Center investgators through collaboration on biostatistical and informatic aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical and bioinformatic assistance (general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development and interpretation); informatic support (project management, IT/hardware management, and database development including caBlG integration); statistical review for PRMS and education and training. Future plans include additional faculty and staff recruitment, development of better systems for clinical data management and reporting, and assisting high throughput technology-oriented share-resources, such as the Integrated Microscopy SR or the new Genome-Wide RNAi Screening and Analysis SR, with improved data management and analysis pipelines.