BIOSTATISTICS AND INFORMATICS

生物统计学和信息学

• 批准号: 8181004
• 负责人: SUSAN G. HILSENBECK
• 金额: $ 22.06万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-17 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181004
• 关键词: Address; Adult; Architecture; Area; Basic Science; Bioinformatics; Biological Markers; Biology; Biometry; Biostatistics Shared Resource; Breast; Cancer Center; Cancer Center Support Grant; Cancer Grant Supplements (P30); Capital; Cellular biology; Chad; Charge; Childhood; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Commit; Common Data Element; Communities; Complex; Computer software; Conduct Clinical Trials; Conflict of Interest; Contracts; DNA Sequence; Data; Data Analyses; Data Base Management; Databases; Development; Discipline; Doctor of Philosophy; Educational process of instructing; Equipment; Evaluation; Experimental Designs; Faculty; Fellowship; Flow Cytometry Shared Resource; Funding; Funding Agency; Future; Genomics; Goals; Grant; Guidelines; Human Resources; Informatics; Information Management; Journals; Laboratories; Laboratory Study; Leadership; Left; Link; Malignant Neoplasms; Management Information Systems; Medical; Medicine; Methodology; Methods; Microscopy; Mission; Molecular; Molecular Medicine; Monitor; Names; Nuclear Receptors; Paper; Pathology; Pediatrics; Phase II Clinical Trials; Play; Police; Population Sciences; Postdoctoral Fellow; Preparation; Process; Production; Prostate; Published Comment; RNA Interference; Recording of previous events; Recovery; Recruitment Activity; Reporting; Reproduction spores; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Review Committee; Role; Schedule; Schools; Scientist; Screening procedure; Services; Source; Statistical Data Interpretation; Strategic Planning; Students; Supervision; System; Time; Tissue Banking; Tissue Banks; Training; Training Programs; Training and Education; United States National Institutes of Health; Vendor; Vocabulary; Work; anticancer research; base; cancer Biomedical Informatics Grid; cancer cell; cancer prevention; college; cost; cost effective; data management; data mining; data sharing; design; epigenomics; experience; gene therapy; genome-wide; high throughput technology; improved; informatics shared resource; interest; interoperability; meetings; member; new technology; next generation; novel strategies; oncology; open source; programs; protein expression; research study; skills; tool; working group

Biostatistics shared resources have, from the beginning of cancer centers, been a centerpiece of the infrastructure that underpins and adds value to a cancer center. The same holds true today, although needs continue to evolve. At present, within the Dan L Duncan Cancer Center, the Biostatistics and Informatics Shared Resource plays a critical role, and going forward into the next funding period, we propose changes and strategic enhancements that will continue to provide the best possible support of research at the Cancer Center. The resource was initially established as part of the first CCSG application in 2006. The Resource grew, primarily, out of existing capabilities and personnel in the biostatistics group in the Breast Center. Directed by Dr. Susan Hilsenbeck, this group had already established strong grant-funded collaborations with non-Breast Center investigators in what is now the Cancer Cell and Gene Therapy Program, the Nuclear Receptors Program, and the Cancer Prevention and Population Science Program, as well as a broad spectrum of investigators in the Breast Program. During our first funding period we continued to grow strategically, adding faculty, staff and services, according to the plan put forward in our initial application, and to address Cancer Center needs. We first added faculty and staff to increase support for bioinformatic analyses. We expanded expertise to support clinical trials, and now, in this competing renewal, propose to formally add support for other kinds of informatics by inclusion of the Cancer Center's developing informatics group. The primary purpose of the Resource is to support the research efforts of Cancer Center investgators through collaboration on biostatistical and informatic aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical and bioinformatic assistance (general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development and interpretation); informatic support (project management, IT/hardware management, and database development including caBlG integration); statistical review for PRMS and education and training. Future plans include additional faculty and staff recruitment, development of better systems for clinical data management and reporting, and assisting high throughput technology-oriented share-resources, such as the Integrated Microscopy SR or the new Genome-Wide RNAi Screening and Analysis SR, with improved data management and analysis pipelines.

从癌症中心成立之初，生物统计学共享资源就一直是支撑癌症中心并为其增加价值的基础设施的核心。今天的情况也是如此，尽管需要继续演变。目前，在丹L邓肯癌症中心，生物统计学和信息学共享资源发挥着至关重要的作用，并进入下一个资助期，我们提出的变化和战略增强，将继续提供在癌症中心的研究最好的支持。该资源最初是作为2006年第一个CCSG应用程序的一部分而建立的。资源 主要是从乳腺中心生物统计组现有的能力和人员中发展起来的。 在Susan Hilsenbeck博士的指导下，该小组已经与非乳腺中心的研究人员建立了强有力的赠款资助合作，现在是癌症细胞和基因治疗计划，核受体计划和癌症预防和人口科学计划，以及乳腺计划中的广泛研究人员。在我们的第一个资助期间，我们继续战略性地增长，增加教师，工作人员和服务，根据我们最初申请中提出的计划，并解决癌症中心的需求。我们首先增加了教职员工，以增加对生物信息学分析的支持。我们扩展了专业知识来支持临床试验，现在，在这个竞争性的更新中，我们建议通过纳入癌症中心的发展中信息学小组来正式增加对其他类型信息学的支持。该资源的主要目的是通过在临床和基础科学研究的设计，实施，分析和解释的生物统计和信息方面的合作，支持癌症中心投资者的研究工作。这将通过提供生物统计学和生物信息学协助（一般咨询、实验设计、协助开展临床试验、统计分析、方法学开发和解释）;信息学支持（项目管理、IT/硬件管理和数据库开发，包括caBlG集成）; PRMS的统计审查以及教育和培训来实现。未来的计划包括增加教职员工 招募，开发更好的临床数据管理和报告系统，并协助高通量技术导向的共享资源，如集成显微镜SR或新的全基因组RNAi筛选和分析SR，改善数据管理和分析管道。