BIOSTATISTICS AND INFORMATICS

生物统计学和信息学

• 批准号: 8181004
• 负责人: SUSAN G. HILSENBECK
• 金额: $ 22.06万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-17 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181004
• 关键词: Address; Adult; Architecture; Area; Basic Science; Bioinformatics; Biological Markers; Biology; Biometry; Biostatistics Shared Resource; Breast; Cancer Center; Cancer Center Support Grant; Cancer Grant Supplements (P30); Capital; Cellular biology; Chad; Charge; Childhood; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Commit; Common Data Element; Communities; Complex; Computer software; Conduct Clinical Trials; Conflict of Interest; Contracts; DNA Sequence; Data; Data Analyses; Data Base Management; Databases; Development; Discipline; Doctor of Philosophy; Educational process of instructing; Equipment; Evaluation; Experimental Designs; Faculty; Fellowship; Flow Cytometry Shared Resource; Funding; Funding Agency; Future; Genomics; Goals; Grant; Guidelines; Human Resources; Informatics; Information Management; Journals; Laboratories; Laboratory Study; Leadership; Left; Link; Malignant Neoplasms; Management Information Systems; Medical; Medicine; Methodology; Methods; Microscopy; Mission; Molecular; Molecular Medicine; Monitor; Names; Nuclear Receptors; Paper; Pathology; Pediatrics; Phase II Clinical Trials; Play; Police; Population Sciences; Postdoctoral Fellow; Preparation; Process; Production; Prostate; Published Comment; RNA Interference; Recording of previous events; Recovery; Recruitment Activity; Reporting; Reproduction spores; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Review Committee; Role; Schedule; Schools; Scientist; Screening procedure; Services; Source; Statistical Data Interpretation; Strategic Planning; Students; Supervision; System; Time; Tissue Banking; Tissue Banks; Training; Training Programs; Training and Education; United States National Institutes of Health; Vendor; Vocabulary; Work; anticancer research; base; cancer Biomedical Informatics Grid; cancer cell; cancer prevention; college; cost; cost effective; data management; data mining; data sharing; design; epigenomics; experience; gene therapy; genome-wide; high throughput technology; improved; informatics shared resource; interest; interoperability; meetings; member; new technology; next generation; novel strategies; oncology; open source; programs; protein expression; research study; skills; tool; working group

Biostatistics shared resources have, from the beginning of cancer centers, been a centerpiece of the infrastructure that underpins and adds value to a cancer center. The same holds true today, although needs continue to evolve. At present, within the Dan L Duncan Cancer Center, the Biostatistics and Informatics Shared Resource plays a critical role, and going forward into the next funding period, we propose changes and strategic enhancements that will continue to provide the best possible support of research at the Cancer Center. The resource was initially established as part of the first CCSG application in 2006. The Resource grew, primarily, out of existing capabilities and personnel in the biostatistics group in the Breast Center. Directed by Dr. Susan Hilsenbeck, this group had already established strong grant-funded collaborations with non-Breast Center investigators in what is now the Cancer Cell and Gene Therapy Program, the Nuclear Receptors Program, and the Cancer Prevention and Population Science Program, as well as a broad spectrum of investigators in the Breast Program. During our first funding period we continued to grow strategically, adding faculty, staff and services, according to the plan put forward in our initial application, and to address Cancer Center needs. We first added faculty and staff to increase support for bioinformatic analyses. We expanded expertise to support clinical trials, and now, in this competing renewal, propose to formally add support for other kinds of informatics by inclusion of the Cancer Center's developing informatics group. The primary purpose of the Resource is to support the research efforts of Cancer Center investgators through collaboration on biostatistical and informatic aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical and bioinformatic assistance (general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development and interpretation); informatic support (project management, IT/hardware management, and database development including caBlG integration); statistical review for PRMS and education and training. Future plans include additional faculty and staff recruitment, development of better systems for clinical data management and reporting, and assisting high throughput technology-oriented share-resources, such as the Integrated Microscopy SR or the new Genome-Wide RNAi Screening and Analysis SR, with improved data management and analysis pipelines.

从癌症中心建立之初，生物统计共享资源就一直是基础设施的核心，为癌症中心提供支撑和增值。今天也是如此，尽管需求在不断变化。目前，在丹·L·邓肯癌症中心内，生物统计学和信息学共享资源起着至关重要的作用，进入下一个资助期，我们提出改变和战略增强，将继续为癌症中心的研究提供最好的支持。该资源最初是作为2006年CCSG首次应用的一部分而建立的。资源