Biostatistics, Information, and Computational Biology

项目摘要 在此更新的SPORE应用程序中，以前的生物统计和数据管理核心被重命名为 更好地体现我们的服务。我们拥有丰富的团队合作经验， 特别是这组SPORE调查人员。我们的SPORE中的所有项目 应用程序将需要一系列临床前和临床实验的统计支持。所有这三个项目 建议临床试验，我们在电子临床试验数据管理方面有着良好的记录， 小型单机构试验和更复杂的随机多机构试验。所有项目也将受益 从我们对生物信息学和整合蛋白质基因组学分析的扩展支持。我们还提供数据 核心1（病理学和生物库）的管理支持。新的信息发展， 生物库和临床注释，承担和成本分担与其他几个大型项目是一个重要的 对孢子有好处。 根据我们的经验，集中的定量科学支持可确保生物统计学家， 生物信息学家和信息学专业人员完全熟悉项目的各个方面， 丹这提供了连续性，提高了效率，并确保采用适当的方法。这 还增加了跨项目的数据共享。信息学和统计学核心（ISC）将提供三大 服务类型：（1）全面的生物统计咨询、实验设计、数据分析和 报告;（2）整合蛋白质组-基因组生物信息学咨询，实验设计，数据分析和 开发、定制、整合和维护数据库和数据管理 系统，以支持SPORE项目和核心的数据管理需求。作为副产品，必要时， 核心还可以开发新的方法，或从其他领域调整现有的方法，以满足独特的需求 的孢子。 SPORE拥有一支专业且经验丰富的团队，拥有一系列技能，这将使其受益匪浅。的 核心还可以灵活地利用癌症中心生物统计学和信息学的资源和人员 共享资源和Zhang实验室，以增强专业知识，或根据需求变化改变对资源的访问。 所有项目的样本量考虑、实验设计和计划分析概述如下： 与核心合作编写。此外，深刻理解SPORE数据和分析需求， 反过来，推动数据库和应用程序的开发，确保信息化解决方案满足广泛的需求， 具体项目，需要的孢子。SPORE的一个特点是可以灵活地终止徒劳的研究， 新线索通过专门的核心人员，我们还可以帮助研究人员设计新的研究并测试新的 这些相关项目的相互促进可能产生的假设。

PROJECT SUMMARY In this renewal SPORE application, the former Biostatistics and Data Management Core is renamed to better reflect our expanded services. We have considerable experience working as a team with groups of investigators in general and this group of SPORE investigators in particular. All projects in our SPORE application will require statistical support for a range of preclinical and clinical experiments. All three projects propose clinical trials, and we have a strong track record of electronic clinical trial data management for both small single institution trials and more complex randomized multi-institution trials. All projects will also benefit from our expanded support for bioinformatics and integrative proteogenomic analysis. We also provide data management support to Core 1 (Pathology and Biobanking). New informatic development in support of biobanking and clinical annotation, undertaken and cost shared with several other large projects is a significant benefit to the SPORE. In our experience, centralized quantitative science support ensures that the biostatisticians, bioinformaticians and informatics professionals are completely familiar with all aspects of the Projects and Cores. This provides continuity, increases efficiency, and ensures that appropriate methods are applied. This also increases cross-Project data sharing. The Informatics and Statistics Core (ISC) will provide three broad types of services: (1) Comprehensive biostatistical consultation, experimental design, data analysis and reporting; (2) Integrative proteome-genomic bioinformatic consultation, experimental design, data analysis and reporting; (3) Development, customization, integration and maintenance of databases and data management systems to support data management needs of SPORE projects and cores. As a by-product, when necessary, the Core can also develop new methods or adapt existing methods from other arenas to meet the unique needs of the SPORE. The SPORE benefits greatly from having a dedicated and experienced team with a range of skills. The Core can also draw flexibly on the resources and personnel in the Cancer Center Biostatistics and Informatics Shared Resource and the Zhang Lab to augment expertise, or alter access to resources as needs change. Sample size considerations, experimental designs, and overviews of planned analyses for all projects were prepared in collaboration with the Core. In addition, deep understanding of SPORE data and analysis needs, in turn, drives database and application development, ensuring that informatic solutions meet the broad, as well as project-specific, needs of the SPORE. A hallmark of SPOREs is flexibility to terminate futile studies and pursue new leads. With dedicated Core personnel, we can also help investigators design new studies and test new hypotheses that may arise by cross-fertilization of these related projects.