Biostatistics, Information, and Computational Biology

项目总结 在这个续订的孢子应用程序中，以前的生物统计和数据管理核心更名为 更好地反映我们扩展的服务。我们有相当多的经验，作为一个团队工作与小组 一般的调查人员，特别是这群孢子调查人员。所有项目都在我们的孢子里 应用将需要一系列临床前和临床试验的统计支持。所有三个项目 建议临床试验，我们在电子临床试验数据管理方面有很强的记录 小型单机构试验和更复杂的随机多机构试验。所有项目也将受益 来自我们对生物信息学和综合蛋白质基因组分析的扩展支持。我们还提供数据 对核心1(病理学和生物库)的管理支持。支持……的信息化新发展 生物库和临床注释，承担并与其他几个大型项目分担成本是一个重要的 对孢子有好处。 根据我们的经验，集中的定量科学支持确保生物统计学家， 生物信息学家和信息学专业人员完全熟悉项目的各个方面，并 核心。这提供了连续性，提高了效率，并确保应用了适当的方法。这 还可以增加跨项目的数据共享。信息和统计核心(ISC)将提供三个广泛的 服务类型：(1)综合生物统计咨询、实验设计、数据分析和 (2)蛋白质组-基因组一体化生物信息学咨询、实验设计、数据分析和 报告；(3)数据库和数据管理的开发、定制、整合和维护 支持孢子项目和核心数据管理需求的系统。作为副产品，在必要时， 核心还可以开发新的方法或从其他领域改编现有方法来满足独特的需求 孢子的种类。 孢子极大地受益于拥有一支敬业和经验丰富的团队，拥有一系列技能。这个 CORE还可以灵活地利用癌症中心生物统计和信息学的资源和人员 共享资源和张实验室，以增强专业知识，或在需求变化时更改对资源的访问。 所有项目的样本量考虑因素、实验设计和计划分析概述 与核心合作编写。此外，深入了解孢子数据和分析需求，在 反过来，推动数据库和应用程序开发，确保Informatic解决方案满足广泛的需求 具体到项目，需要的孢子。孢子的一个特点是可以灵活地终止徒劳的研究并继续下去 新的线索。有了专门的核心人员，我们还可以帮助研究人员设计新的研究和测试新的 这些相关项目的交叉受精可能产生的假设。

PROJECT SUMMARY In this renewal SPORE application, the former Biostatistics and Data Management Core is renamed to better reflect our expanded services. We have considerable experience working as a team with groups of investigators in general and this group of SPORE investigators in particular. All projects in our SPORE application will require statistical support for a range of preclinical and clinical experiments. All three projects propose clinical trials, and we have a strong track record of electronic clinical trial data management for both small single institution trials and more complex randomized multi-institution trials. All projects will also benefit from our expanded support for bioinformatics and integrative proteogenomic analysis. We also provide data management support to Core 1 (Pathology and Biobanking). New informatic development in support of biobanking and clinical annotation, undertaken and cost shared with several other large projects is a significant benefit to the SPORE. In our experience, centralized quantitative science support ensures that the biostatisticians, bioinformaticians and informatics professionals are completely familiar with all aspects of the Projects and Cores. This provides continuity, increases efficiency, and ensures that appropriate methods are applied. This also increases cross-Project data sharing. The Informatics and Statistics Core (ISC) will provide three broad types of services: (1) Comprehensive biostatistical consultation, experimental design, data analysis and reporting; (2) Integrative proteome-genomic bioinformatic consultation, experimental design, data analysis and reporting; (3) Development, customization, integration and maintenance of databases and data management systems to support data management needs of SPORE projects and cores. As a by-product, when necessary, the Core can also develop new methods or adapt existing methods from other arenas to meet the unique needs of the SPORE. The SPORE benefits greatly from having a dedicated and experienced team with a range of skills. The Core can also draw flexibly on the resources and personnel in the Cancer Center Biostatistics and Informatics Shared Resource and the Zhang Lab to augment expertise, or alter access to resources as needs change. Sample size considerations, experimental designs, and overviews of planned analyses for all projects were prepared in collaboration with the Core. In addition, deep understanding of SPORE data and analysis needs, in turn, drives database and application development, ensuring that informatic solutions meet the broad, as well as project-specific, needs of the SPORE. A hallmark of SPOREs is flexibility to terminate futile studies and pursue new leads. With dedicated Core personnel, we can also help investigators design new studies and test new hypotheses that may arise by cross-fertilization of these related projects.