CORE--FAMILIAL BREAST CANCER RESOURCE

我们建立家族性乳腺癌资源的主要使命是 降低乳腺癌的发病率、发病率和死亡率。本 最后，该资源将用于识别和研究遗传标记， 乳腺癌易感性，并提供高风险妇女参与 在癌症筛查和预防试验中。 家族性乳腺癌的索引病例是从我们自己的肿瘤中确定的 银行、医生推荐、直接媒体征集、筛选 乳房X光检查报告和其他来源。应计费用已超过我们的 原始预测基本上。数据库目前包括223个 代表12 137人的家庭，包括707名成员， 有乳腺癌病史。数据收集包括有据可查的学位 扩大到包括所有乳腺癌病例的二阶亲属。 数据项包括人口统计学和联系信息以及临床 所有癌症和所有良性乳腺疾病的信息。期间 在下一个拨款期，我们建议更加重视检讨工作， 核实临床数据和招募西班牙裔家庭。 在资源之间建立了良好的合作关系 和当地乳腺癌试验（例如NSABP乳腺癌预防试验） 以便有阳性家族史的试验参与者 资源和资源将感兴趣的高风险患者转介给 审判 除了数据库，资源还包括组织库。 在获得知情同意后，从关键部位采集血样， 有3名或以上受影响成员的家庭成员， 冷冻保存的外周血淋巴细胞（PBL）和冷冻血清。的 库目前包含113个PBL和血清样本，代表30 家庭另有300人已经成为目标，但尚未 绘制处理知情同意书和抽血的程序， 当地和外地，用于处理血液，以及所有的 相关的计算机库存和跟踪系统，是很好的- 确立了习我们建议在下一次供资期间继续开展这一活动。 期此外，对于受影响的成员，我们将检索档案 组织样本在本申请的项目4中，我们提出使用DNA 从库PBL的检查几个肿瘤抑制基因牵连， 遗传性和散发性乳腺癌。

Our primary mission in establishing the Familial Breast Cancer Resource is to reduce the incidence, morbidity and mortality of breast cancer. To this end, the resource will be used to identify and study genetic markers of breast cancer susceptibility, and to offer high-risk women participation in cancer screening and prevention trials. Index cases of familial breast cancer are identified from our own tumor bank, physician referral, direct media solicitation, screening of mammography reports, and other sources. Accruals have exceeded our original projections substantially. The database currently includes 223 families representing 12,137 individuals, including 707 members with a history of breast cancer. Data collection includes well-documented degrees expanded to include second order relatives of all breast cancer cases. Data items include demographic and contact information as well as clinical information on all cancers, and all benign breast conditions. During the next funding period we propose to place additional emphasis on review and verification of clinical data and on recruitment of Hispanic families. There is a well-established cooperative relationship between the resource and local breast cancer trials (e.g. NSABP Breast Cancer Prevention Trial) so that trial participants with a positive family history are referred to the resource and the resource refers interested high risk patients to the trial. In addition to the databases, the resource also includes tissue banks. After obtaining informed consent, blood samples are obtained from key members of families with 3 or more affected members for banking as cryopreserved peripheral blood lymphocytes (PBL's) and frozen serum. The bank currently contains 113 PBL and serum samples representing 30 families. An additional 300 individuals are already targeted but not yet drawn. Procedures for handling informed consents and drawing bloods, both locally and out of town, for processing bloods, as well as all of the associated computer inventories and tracking systems, are well- established. We propose to continue this activity during the next funding period. Additionally, for affected members, we will retrieve archival tissue samples. In Project 4 of this application we propose to use DNA from banked PBL's to examine several tumor suppressor genes implicated in both hereditary and sporadic breast cancer.