The National Drug Abuse Clinical Trials Network: New England Consortium Node

国家药物滥用临床试验网络：新英格兰联盟节点

• 批准号: 10442107
• 负责人: Gail D'Onofrio
• 金额: $ 9.16万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10442107
• 关键词: Administrative Supplement; Clinical Trials Network; Cocaine Users; Data Analyses; Drug abuse; Enrollment; Ethnic Origin; Hispanics; Latinx; Meta-Analysis; National Institute of Drug Abuse; New England; Outcome; Race; Randomized; Registries; Research Personnel; Substance Use Disorder; Time; Treatment outcome; comparative effectiveness; psychosocial; sex; substance user; success

ABSTRACT This Administrative Supplement to the NIDA Clinical Trials Network: New England Consortium Node is to support three specific concepts: 1) Comprehensive Meta-Analysis of CTN Treatment Outcomes by Race and Sex This project will perform additional meta-analyses examining whether/how race and sex interact to predict likelihood of treatment success and likelihood of randomization into a CTN trial versus screen fail. Exploratory analysis will be conducted evaluating how these outcomes vary by ethnicity (i.e. Hispanic/Latinx). 2) Using Integrative Data Analysis to Examine the Impact of Psychosocial Treatments for Black Cocaine Users Enrolled in the CTN Using integrative data analysis of multiple CTN trials, this project will examine comparative effectiveness and moderators of substance use disorder treatments for Black substance users. 3) NIDA CTN Substance Use Disorder (SUD) Registry Initiative concept This project will establish a NIDA CTN Substance Use Disorder Registry to allow investigators to follow substance users over time.

抽象的 NIDA 临床试验网络的行政补充：新英格兰联盟 Node是支持三个具体的概念： 1) 按种族和性别对 CTN 治疗结果进行综合荟萃分析 该项目将进行额外的荟萃分析，检查种族和性别是否/如何 相互作用以预测治疗成功的可能性和随机化的可能性 CTN 试验与筛选失败。将进行探索性分析，评估这些 结果因种族（即西班牙裔/拉丁裔）而异。 2) 使用综合数据分析来检验社会心理的影响 加入 CTN 的黑色可卡因使用者的治疗 该项目将利用多个 CTN 试验的综合数据分析 物质使用障碍治疗的比较有效性和调节因素 黑色物质使用者。 3) NIDA CTN 药物使用障碍 (SUD) 注册倡议概念 该项目将建立 NIDA CTN 物质使用障碍登记处，以允许 调查人员随着时间的推移跟踪药物使用者。