Yale-METRO Metropolitan Emergency Trial netwoRK to advance patient Outcomes

耶鲁大学-METRO 大都会紧急试验网络可改善患者的治疗效果

• 批准号: 10552382
• 负责人: Gail D'Onofrio
• 金额: $ 50.09万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552382
• 关键词: Acute; Adult; Agreement; Applications Grants; Area; Blood Vessels; COVID-19 pandemic; Cardiac; Cardiovascular system; Catchment Area; Cessation of life; Clinical; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Communities; Connecticut; Data; Data Collection; Data Coordinating Center; Detection; Diagnosis; Electronics; Emergency Care; Emergency Department Physician; Emergency Medicine; Emergency Situation; Emergency department visit; Enrollment; Ensure; Faculty; Funding; Future; Generations; Geography; Health; Health system; Healthcare; Hematologist; Hematology; Home; Hospitals; Hour; Injury; Institution; Institutional Review Boards; Integrated Health Care Systems; Intervention; Lead; Leadership; Life; Long-Term Care; Longterm Follow-up; Lung; Massachusetts; Medicine; Mentors; Monitor; Morbidity - disease rate; Multi-Institutional Clinical Trial; Multicenter Trials; Neurologic; Neurologist; Neurology; Neurosurgeon; New England; New York; New York City; Outcome; Patient-Focused Outcomes; Pediatric Hospitals; Persons; Population; Population Heterogeneity; Prehospital Emergency Care; Presbyterian Church; Principal Investigator; Procedures; Process; Quality Control; Reporting; Research; Research Personnel; Research Proposals; Rhode Island; Scientist; Seasons; Stroke; Surgeon; System; Talents; Technology; Testing; Time; Training; Trauma; United States National Institutes of Health; Universities; Vision; advanced disease; clinical center; collaborative environment; data management; data standards; design; disability; experience; hospital care; improved; innovation; innovative technologies; interest; medical specialties; metropolitan; multidisciplinary; participant enrollment; patient population; pediatric emergency; pediatric patients; quality assurance; recruit; respiratory; skills; success; synergism; uptake

The Yale-Metropolitan Emergency Trial network to advance patient Outcomes (Yale-METRO) is anchored by Yale New Haven Health System (YNHHS) as the Hub and 5 leading partner integrated health systems (1) Hartford Healthcare, (2) Rhode Island/Brown University Health System, (3) Mount Sinai Health System, (4) New York Presbyterian/Weill Cornell Medicine, and (5) Montefiore Health System. Yale-New Haven Hospital is the 7th largest hospital in the U.S. and in collaboration with YNHHS and the Spokes with their respective networks these geographically proximate institutions, cover a densely populated catchment area including more than 8 million people throughout Connecticut, Rhode Island, Southeast NY, Southern MA, and 4 boroughs of New York City, with 1,739,027 Emergency Department visits offering access to a large and diverse population of acutely ill adult and pediatric patients. Principal Investigators Dr. Gail D'Onofrio (Emergency Medicine) and Dr. Kevin Sheth (Neurology) bring a complementary set of leadership skills, high-level clinical trial experience, and an excellent organizational framework. Each have demonstrated expertise in leading and conducting multicenter trials, and a proven track record of high-quality ED and pre-hospital recruitment, and retention in studies, even during the COVID-19 Pandemic. They have collaborated and are actively engaged in multicenter trials with the Spoke institutions and investigators. These interactions include leveraging successful contributions currently in place for NIH networks such as NeuroNEXT and Stroke Net. They have access to a cadre of impressive multispecialty faculty, creating a highly collaborative environment focused on the emergency care related to presentations and diagnoses of interest including, neurological, cardiovascular, respiratory, hematology and trauma. Finally, they have created mechanisms to facilitate enrollment 24 hours, 7 days a week that are already in place. The proposal is strengthened by a: (1) Pool of talented investigators with nationally recognized researchers and MPIs with experience implementing multicenter trials (2) Large diverse patient population (3) Informaticist and analytic team bringing innovative technological strategies and processes for rapid uptake of Spokes, recruitment, data collection, monitoring and quality; (4) Robust track record of mentoring junior investigators and (5) Expertise in developing future proposals for SIREN research. Yale-METRO offers all the components for conducting high-quality research and unique opportunities to use innovative technology advances for disease detection, patient enrollment, data collection and high-quality assurances procedures. Thus, Yale-METRO offers unique opportunities to strengthen the SIREN Network, designing, testing, and discovering interventions and therapies improving patient outcomes.

旨在提高患者治疗效果的耶鲁-大都会紧急试验网络 (Yale-METRO) 以耶鲁纽黑文医疗系统 (YNHHS) 为中心，以及 5 个领先的合作伙伴综合医疗系统为基础：(1) 哈特福德医疗保健系统、(2) 罗德岛/布朗大学医疗系统、(3) 西奈山医疗系统、(4) 纽约长老会/威尔康奈尔医学中心和 (5) 蒙蒂菲奥里医疗系统。耶鲁-纽黑文医院是美国第七大医院，与 YNHHS 和 Spokes 合作，这些地理位置邻近的机构覆盖了人口稠密的服务区，包括康涅狄格州、罗德岛州、纽约东南部、马萨诸塞州南部和纽约市 4 个行政区的超过 800 万人，急诊科就诊次数达 1,739,027 次，为大量不同人群提供了服务。 患有急性疾病的成人和儿童患者。 首席研究员 Gail D'Onofrio 博士（急诊医学）和 Kevin Sheth 博士（神经病学）带来了一套互补的领导技能、高水平的临床试验经验和出色的组织框架。每个人都在领导和开展多中心试验方面表现出了专业知识，并且在高质量急诊室和院前招募以及研究保留方面拥有良好的记录，即使在 COVID-19 大流行期间也是如此。他们与 Spoke 机构和研究人员合作并积极参与多中心试验。这些互动包括利用目前对 NIH 网络（例如 NeuroNEXT 和 Stroke Net）的成功贡献。他们拥有一批令人印象深刻的多专业教师队伍，创造了一个高度协作的环境，专注于与感兴趣的演示和诊断相关的紧急护理，包括神经学、心血管、呼吸、血液学和创伤。最后，他们创建了每周 7 天、24 小时便利注册的机制，并且这些机制已经到位。 该提案通过以下因素得到加强：(1) 一批才华横溢的研究人员，包括国家认可的研究人员和具有实施多中心试验经验的 MPI (2) 大量多样化的患者群体 (3) 信息学家和分析团队带来创新的技术策略和流程，以快速采用 Spokes、招募、数据收集、监测和质量； (4) 指导初级研究人员的良好记录；(5) 为 SIREN 研究制定未来提案的专业知识。 耶鲁-麦德龙提供了进行高质量研究的所有组成部分，以及利用创新技术进步进行疾病检测、患者登记、数据收集和高质量保证程序的独特机会。因此，耶鲁-麦德龙提供了独特的机会来加强 SIREN 网络，设计、测试和发现改善患者治疗效果的干预措施和疗法。