National Institute on Drug Abuse Clinical Trial Network: New England Consortium Node
National Institute on Drug Abuse Clinical Trial Network: New England Consortium Node
批准号:
10684501
负责人:
Gail D'Onofrio
金额:
$442.87万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-09-01 至 2023-02-28
关键词:
Accident and Emergency departmentAncillary StudyBuprenorphineCase SeriesClinicalClinical Trials NetworkCompetenceDevelopmentEffectivenessElectronic Health RecordEligibility DeterminationEmergency Department patientEmergency department visitHourMental disordersNational Institute of Drug AbuseNew EnglandOpioidPatientsPharmaceutical PreparationsPhenotypeProceduresRandomized Controlled TrialsResearchResourcesSigns and SymptomsSiteSoft Tissue InfectionsTrainingValidationWithdrawalWithdrawal Symptomaddictionchronic paincompare effectivenesscost effectivedesignexperienceimplementation facilitationopioid overdoseopioid useopioid use disorderopioid withdrawalpatient engagementprimary outcomerecruit
中文摘要
摘要
这项研究将(1)招聘、培训和向大约30个急诊部(ED)站点提供资源
在美国各地使用实施促进战略为患者提供ED发起的BUP
出现阿片使用障碍(OUD),没有接受阿片使用障碍的药物治疗(Moud)。一次
如果实施得到充分实现,这些站点将(2)进行随机对照试验(RCT),以
丁丙诺啡舌下含服与丁丙诺啡缓释片的疗效比较
(XR-BUP)关于勃起功能障碍患者就诊后7天参与正式成瘾治疗的情况。此外,在
作为这项研究的辅助组成部分,我们将(3)评估XR-BUP在患有临床阿片类药物的ED患者中的使用
戒断量表(COS)在病例系列中的得分<;8,以潜在地扩大较大规模患者的资格
RCT适用于那些出现很少或没有阿片类药物戒断症状的人。最后,我们将(4)开发和验证
ED电子健康记录(HER)与阿片类药物相关的表型,这两种表型都将告知主要的随机对照试验。
英文摘要
ABSTRACT
This study will (1) recruit, train and provide resources to approximately 30 Emergency Department (ED) sites
throughout the U.S. using implementation facilitation strategies to provide ED-initiated BUP for patients
presenting with opioid use disorder (OUD) not receiving medications for opioid use disorder (MOUD). Once
implementation is adequately achieved, the sites will (2) conduct a randomized controlled trial (RCT) to
compare the effectiveness of sublingual buprenorphine (SL-BUP) versus extended-release buprenorphine
(XR-BUP) on ED patients' engagement in formal addiction treatment 7-days after their ED visit. In addition, in
an ancillary component of the study, we will (3) assess the use of XR-BUP in ED patients with Clinical Opioid
Withdrawal Scale (COS) scores < 8 in a case series to potentially expand the eligibility of patients in the larger
RCT to those presenting with little to no opioid withdrawal symptoms. Finally, we will (4) develop and validate
ED electronic health record (HER) opioid-related phenotypes, both of which will inform the main RCT.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Yale-METRO Metropolitan Emergency Trial netwoRK to advance patient Outcomes
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批准号:10552382
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项目类别:
-
资助金额:$50.09万
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财政年份:2023
-
负责人:Gail D'Onofrio
-
依托单位:
Clinical Trials Network: Admin Supplement: Integrating MOUD with BUP in Non-medical Community Settings
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批准号:10801347
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项目类别:
-
资助金额:$5.79万
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财政年份:2023
-
负责人:Gail D'Onofrio
-
依托单位:
Standard versus High Dose ED-Initiated Buprenorphine Induction
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批准号:10801950
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项目类别:
-
资助金额:$128.6万
-
财政年份:2023
-
负责人:Gail D'Onofrio
-
依托单位:
Clinical Trials Network New England Consortium Node: Admin Supplement CTN0131
-
批准号:10655837
-
项目类别:
-
资助金额:$163.84万
-
财政年份:2022
-
负责人:Gail D'Onofrio
-
依托单位:
Clinical Trials Network New England Consortium Node: Admin Supplement CTN0126
-
批准号:10655828
-
项目类别:
-
资助金额:$68.83万
-
财政年份:2022
-
负责人:Gail D'Onofrio
-
依托单位:
The National Drug Abuse Clinical Trials Network: New England Consortium Node
-
批准号:10450554
-
项目类别:
-
资助金额:$170.0万
-
财政年份:2021
-
负责人:Gail D'Onofrio
-
依托单位:
The National Drug Abuse Clinical Trials Network: New England Consortium Node
-
批准号:10442107
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项目类别:
-
资助金额:$9.16万
-
财政年份:2021
-
负责人:Gail D'Onofrio
-
依托单位:
The National Drug Abuse Clinical Trials Network: New England Consortium Node
-
批准号:10451986
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项目类别:
-
资助金额:$23.31万
-
财政年份:2021
-
负责人:Gail D'Onofrio
-
依托单位:
EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use Disorder
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批准号:9928151
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项目类别:
-
资助金额:$38.22万
-
财政年份:2018
-
负责人:Gail D'Onofrio
-
依托单位:
EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use Disorder
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批准号:10379284
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项目类别:
-
资助金额:$181.52万
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财政年份:2018
-
负责人:Gail D'Onofrio
-
依托单位:
EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use Disorder
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批准号:9903269
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项目类别:
-
资助金额:$168.53万
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财政年份:2018
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负责人:Gail D'Onofrio
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依托单位:
Yale Drug use, Addiction and HIV Research Scholars (DAHRS)
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批准号:10430158
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项目类别:
-
资助金额:$50.94万
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财政年份:2013
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负责人:Gail D'Onofrio
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依托单位:
Yale Drug use, Addiction and HIV Research Scholars (DAHRS)
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批准号:10192686
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项目类别:
-
资助金额:$50.37万
-
财政年份:2013
-
负责人:Gail D'Onofrio
-
依托单位:
Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)
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批准号:8829809
-
项目类别:
-
资助金额:$49.15万
-
财政年份:2013
-
负责人:Gail D'Onofrio
-
依托单位:
Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)
-
批准号:8510031
-
项目类别:
-
资助金额:$50.81万
-
财政年份:2013
-
负责人:Gail D'Onofrio
-
依托单位:
Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)
-
批准号:8650799
-
项目类别:
-
资助金额:$50.18万
-
财政年份:2013
-
负责人:Gail D'Onofrio
-
依托单位:
Yale-Drug use, Addiction, and HIV prevention Research Scholars (Yale-DAHRS)
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批准号:10672039
-
项目类别:
-
资助金额:$54.06万
-
财政年份:2013
-
负责人:Gail D'Onofrio
-
依托单位:
The SBIRT Training in Yale Residency Programs: Implementation and Dissemination
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批准号:8286789
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项目类别:
-
资助金额:$0.0万
-
财政年份:2008
-
负责人:Gail D'Onofrio
-
依托单位:
Models of SBIRT for Opioid Dependent Patients in the Emergency Department
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批准号:8097513
-
项目类别:
-
资助金额:$107.17万
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财政年份:2008
-
负责人:Gail D'Onofrio
-
依托单位:
Models of SBIRT for Opioid Dependent Patients in the Emergency Department
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批准号:7586474
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项目类别:
-
资助金额:$92.52万
-
财政年份:2008
-
负责人:Gail D'Onofrio
-
依托单位:
海外基金