Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)

耶鲁大学药物滥用、成瘾和艾滋病毒研究学者 (Yale-DAHRS)

• 批准号: 8510031
• 负责人: Gail D'Onofrio
• 金额: $ 50.81万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510031
• 关键词: AIDS prevention; Accident and Emergency department; Acquired Immunodeficiency Syndrome; Acute; Address; Adolescent; Aging; Alcohol or Other Drugs use; Alcohols; Area; Behavioral Research; Biomedical Research; Buprenorphine; Cardiovascular Diseases; Chronic; Clinic; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials; Communicable Diseases; Communities; Community Hospitals; Complex; Data Analyses; Data Collection; Data Set; Demography; Development; Development Plans; Diagnostic; Discipline of obstetrics; Disease; Drug Addiction; Drug abuse; Effectiveness; Elderly; Emergency Medicine; Engineering; Ensure; Evaluation; Faculty; Federally Qualified Health Center; Fostering; Foundations; Funding; Future; Gender; Grant; Gynecology; HIV; Health; Health Sciences; Hepatitis; Hepatitis C; Hospitals; Imprisonment; Information Dissemination; Inpatients; Institutes; Interdisciplinary Study; Internal Medicine; Intervention; Intoxication; Investigation; Knowledge; Laboratories; Leadership; Lung diseases; Medical; Medical center; Medicine; Mentors; Meta-Analysis; Minority; Modeling; NCI Scholars Program; New England; Opiate Addiction; Outcome; Overdose; Pain; Patients; Pediatrics; Population Heterogeneity; Prevention; Primary Health Care; Principal Investigator; Provider; Psychiatry; Psychology; Public Health Informatics; Publishing; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Research Training; Risk; Risk Factors; Science; Scientist; System; Time; Tobacco; Training; Training Programs; Trauma; United States National Institutes of Health; Veterans; Withdrawal; Woman; Women' s Health; Work; Writing; addiction; base; career; career development; clinical epidemiology; cohort; cost effective; data management; design; experience; improved; innovative technologies; named group; post-doctoral training; prescription drug abuse; programs; racial and ethnic disparities; responsible research conduct; screening; screening, brief intervention, referral, and treatment; skills; statistics; success; systematic review; tertiary care; tool; tool development; treatment center; ward

DESCRIPTION (provided by applicant): There is a critical need to develop a diverse pool of highly trained clinician scholars to foster the development of biomedical, behavioral and clinical research related to drug abuse, addiction, and HIV prevention and treatment in general medical settings. Patients who abuse substances are more likely to be seen in general medical settings such as emergency departments (ED), general medical primary care clinics and inpatient wards, HIV and adolescent health clinics, and women's health centers. These patients often present with a complex array of acute consequences and complications (e.g. intoxication, overdose, withdrawal, trauma and infectious diseases) of substance use as well as chronic conditions such as HIV disease, hepatitis, pulmonary and cardiovascular disease. Objectives: The Yale-Drug Abuse, Addiction, and HIV Research Scholars (DAHRS) program provides a comprehensive three year post-doctorate, interdisciplinary, Mentored Career Development Program to improve drug abuse, addiction, and HIV medical outcomes integrating prevention and treatment in general medical settings including ED, primary care, HIV, adolescent, and women's health clinics. Specifically, Yale-DAHRS will: [Aim 1] Develop clinician scientists with the knowledge, skills, and ability to become independent investigators, generating findings of practical value with significant impact to improve health outcomes of patients with and at risk for drug abuse, addiction, and HIV; [Aim 2] Develop future leaders by providing Scholars with leadership tools and skills and creating individualized programs to ensure success in leading multidisciplinary research teams in studying drug abuse, addiction and HIV, and implementation and integration of research findings into general medical settings; and [Aim 3] Enhance the diversity of drug abuse, addiction, and HIV researchers. Addressing women and minority faculty under representation will enhance the diversity of investigators and research topics, broaden perspectives in setting research priorities, increase clinical trial participation, and expand knowledge. Working synergistically with Yale's established training programs in drug abuse, HIV and clinical investigation, Yale- DAHRS will capitalize on existing academic infrastructure and expertise to ensure success. Unique, features include: (1) An interdisciplinary, diverse faculty of independent researchers in illicit and prescription drug abuse and addiction, tobacco, alcohol, HIV, and medical complexities such as pain and hepatitis C; (2) Synergy with well established, high quality post-doctoral training programs at Yale; (3) The use of clinical informatics for data collection, data management, diagnostic tool development, and information dissemination; and (4) The integration of such diverse fields as public health, informatics, clinical epidemiology, systems engineering and demography with the traditional clinical sciences of internal medicine, emergency medicine, HIV medicine, pediatrics, obstetrics and gynecology, psychiatry, and psychology; (5) Established clinical research laboratories, including the Yale-New Haven Hospital, a tertiary care center for southern New England and a community hospital for the Greater New Haven Area, serving an ethnically, racially, culturally, and economically diverse population, a Veterans Affairs Medical Center and community treatment centers such as the APT Foundation and Federally Qualified Health Centers; (6) Synergies with established research centers and institutes such as the Center for Interdisciplinary Research on AIDS and the Veterans Aging Cohort on HIV. Career Development Plan: Yale-DAHRS is a three year research training program that will prepare a total of six clinician investigators for careers focusing on drug abuse, addiction, and HIV in general medical settings during its first funding cycle. Scholars will earn the Master in Health Sciences degree, combining rigorous training in research methodology, statistics and design with seminars in topics related to drug abuse, addiction, and HIV content, leadership, grant writing and responsible conduct of research. Candidates will complete published mentored research project(s) and prepare an application for the next career step; i.e. NIH R21, R03, R15, R34 mechanism. The collaboration of the multidisciplinary faculty and the combined robust strengths of two principal investigators from Emergency and Internal Medicine, both with extensive experience mentoring and as independent funded investigators will drive the Yale-DAHRS program. Potential Research Projects: Multiple research projects are "shovel ready" for Scholar training and can be completed within our allotted time frame, such as secondary data analysis using national large datasets e.g. VA Aging Cohort (HIV); risk factors, prevention and treatment of prescription drug abuse, office-based treatment of opioid dependence with buprenorphine, systematic reviews and meta-analyses, creation of cost effective evaluation models for patients with drug abuse, addiction and HIV including prescription drug abuse; investigation of gender and racial/ethnic disparities in identification and treatment interventions and outcomes; evaluation of screening, and treatment initiation in special populations (i.e. adolescent-elderly, veterans, incarcerated, HIV); comparison of models of screening, brief intervention and referral to treatment (SBIRT) delivery by providers and other innovative technologies; effectiveness and implementation of SBIRT science in general medicine practice with acute and chronic medical complexities.

描述（由申请人提供）：迫切需要培养一批训练有素的临床医生学者，以促进与药物滥用、成瘾和艾滋病毒预防和治疗相关的生物医学、行为和临床研究的发展。滥用药物的患者更有可能出现在普通医疗机构，如急诊科、普通医疗初级保健诊所和住院病房、艾滋病毒和青少年保健诊所以及妇女保健中心。这些患者往往会出现一系列复杂的药物使用急性后果和并发症（如中毒、过量、停药、创伤和传染病），以及艾滋病毒病、肝炎、肺病和心血管疾病等慢性病。目标：耶鲁-药物滥用、成瘾和艾滋病毒研究学者（DAHRS）项目提供了一个全面的三年博士后、跨学科、指导职业发展项目，以改善药物滥用、成瘾和艾滋病毒的医疗结果，将预防和治疗整合到一般医疗环境中，包括急诊科、初级保健、艾滋病毒、青少年和妇女健康诊所。具体来说，耶鲁- dahrs将：[目标1]培养具有知识、技能和能力的临床科学家，使他们成为独立的研究人员，产生具有实际价值的发现，对改善糖尿病患者和有风险患者的健康结果有重大影响