The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age

全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响

基本信息

项目摘要

PROJECT SUMMARY This U19 application, referred to as SWAN-Aging, is designed to determine the extent to which midlife health, and specifically the menopause transition (MT), affects successful aging in women. This proposal capitalizes on the rich resources of the Study of Women's Health Across the Nation (SWAN), a longitudinal cohort study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT. A total of 3302 Black, Chinese, Japanese, Hispanic and White women were enrolled at seven sites, with 74% of still- living women completing up to 16 visits spanning the pre-menopause to post-menopause. SWAN has described the natural history of the MT -- its timing, patterns of hormonal changes, and symptoms – and their relation to midlife health indicators. In SWAN-Aging, we will extend follow-up of the SWAN cohort into early old age (66-75 years) and will prospectively link comprehensive longitudinal characterization of both the MT and midlife health indicators to functioning and health across multiple domains in early old age, a pivotal time of transition into old age when adverse changes in health and functioning begin to accumulate. The global specific aims of this U19 application are to: 1) determine the impact of MT characteristics and trajectories of midlife health indicators on the preservation of cognitive, physical, genitourinary, sexual, and psychosocial function and sleep in early old age; 2) determine the impact of MT characteristics and trajectories of midlife health indicators on risk of adverse health outcomes, including falls, osteoporosis and fractures, poor cardiometabolic function, cardiovascular events and early mortality; 3) determine if racial/ethnic disparities in health and functioning in early old age are attributable to midlife racial/ethnic differences in MT characteristics and midlife health indicators; and 4) translate the SWAN and SWAN-Aging findings for women and their health care providers. These aims will be achieved through three integrated scientific Projects that are organized around key health domains (functioning, cardiometabolic health and musculoskeletal health) and linked by a common focus on MT characteristics and midlife changes in health indicators as key exposures. The three Projects will be supported by three Cores which will a) provide the necessary organizational infrastructure to conduct this study and to disseminate results to the research and medical communities; b) conduct accurate, high volume assays, adopting new methods as needed to provide state-of-the-art laboratory data, and c) oversee the design and conduct of the core clinic visit, data collection and data management, and the creation of the analytic datasets. SWAN-Aging will include one clinic visit and a National Death Index search to ensure complete mortality ascertainment for the cohort. SWAN-Aging is uniquely positioned to fill important scientific gaps in understanding of the impact of the MT and midlife indicators on women's health and functioning in early old age and to facilitate the application of new knowledge to clinical practice. This study will provide valuable insights into modifiable factors relevant to the design of future prevention and treatment programs.
项目总结

项目成果

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SHERRI-ANN M BURNETT-BOWIE其他文献

SHERRI-ANN M BURNETT-BOWIE的其他文献

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{{ truncateString('SHERRI-ANN M BURNETT-BOWIE', 18)}}的其他基金

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
  • 批准号:
    10263894
  • 财政年份:
    2020
  • 资助金额:
    $ 31.6万
  • 项目类别:
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
  • 批准号:
    10292495
  • 财政年份:
    2020
  • 资助金额:
    $ 31.6万
  • 项目类别:
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
  • 批准号:
    10471452
  • 财政年份:
    2020
  • 资助金额:
    $ 31.6万
  • 项目类别:
VITAMIN D DEFICIENCY: INSULIN RESISTANCE AND FGF-23
维生素 D 缺乏:胰岛素抵抗和 FGF-23
  • 批准号:
    7731274
  • 财政年份:
    2008
  • 资助金额:
    $ 31.6万
  • 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
  • 批准号:
    7433724
  • 财政年份:
    2006
  • 资助金额:
    $ 31.6万
  • 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
  • 批准号:
    7147855
  • 财政年份:
    2006
  • 资助金额:
    $ 31.6万
  • 项目类别:
VITAMIN D DEFICIENCY: INSULIN RESISTANCE AND FGF-23
维生素 D 缺乏:胰岛素抵抗和 FGF-23
  • 批准号:
    7607088
  • 财政年份:
    2006
  • 资助金额:
    $ 31.6万
  • 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
  • 批准号:
    7880829
  • 财政年份:
    2006
  • 资助金额:
    $ 31.6万
  • 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
  • 批准号:
    7647447
  • 财政年份:
    2006
  • 资助金额:
    $ 31.6万
  • 项目类别:
EFFECTS OF DIETARY PHOSPHATE ON THE REGULATION OF FGF-23
膳食磷酸盐对 FGF-23 调节的影响
  • 批准号:
    7205064
  • 财政年份:
    2004
  • 资助金额:
    $ 31.6万
  • 项目类别:

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