The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
基本信息
- 批准号:10447272
- 负责人:
- 金额:$ 31.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdoptedAffectAgeAgingAmericanBiological AssayBlood PressureBlood VesselsBody CompositionBody WeightBone DensityCardiovascular DiseasesCardiovascular systemCessation of lifeCharacteristicsChinese PeopleChronicClinic VisitsClinicalCognitiveCohort StudiesCommunitiesDataData CollectionData SetEarly InterventionElderlyEnrollmentEnsureEventFollow-Up StudiesFractureFutureGenitourinary systemGoalsGonadal Steroid HormonesHealthHealth PersonnelHemorrhageHispanicsHormonal ChangeInflammationInfrastructureJapanese PopulationKnowledgeLaboratoriesLeadershipLife ExpectancyLife ExperienceLife StyleLinkLipidsLongitudinal cohortLongitudinal cohort studyMeasuresMedicalMenopauseMenstruationMental DepressionMental HealthMethodsMusculoskeletalNatural HistoryOsteoporosisOutcomePatternPersonal SatisfactionPhysical FunctionPhysiologicalPhysiologyPopulationPositioning AttributePostmenopausePremenopausePrevention programQuality of lifeResearchResourcesRiskRisk FactorsRoleSiteSleepStructureStudy of Women&aposs Health Across the NationSymptomsTimeTranslatingVisitWomanWomen&aposs Healthage relatedagedbody systembonebone strengthcardiometabolic riskcardiometabolismcardiovascular disorder riskclinical practicecognitive disabilitycognitive performancecohortdata managementdepressive symptomsdesigndisabilitydisorder preventionenhancing factorethnic differencefallshealth disparityhuman old age (65+)indexinginsightmenmiddle agemortalitymulti-racialphysical conditioningpreservationprospectivepsychosocialpublic health prioritiesracial and ethnicracial and ethnic disparitiessocioeconomicstreatment program
项目摘要
PROJECT SUMMARY
This U19 application, referred to as SWAN-Aging, is designed to determine the extent to which midlife health,
and specifically the menopause transition (MT), affects successful aging in women. This proposal capitalizes
on the rich resources of the Study of Women's Health Across the Nation (SWAN), a longitudinal cohort study
initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT. A total
of 3302 Black, Chinese, Japanese, Hispanic and White women were enrolled at seven sites, with 74% of still-
living women completing up to 16 visits spanning the pre-menopause to post-menopause. SWAN has
described the natural history of the MT -- its timing, patterns of hormonal changes, and symptoms – and their
relation to midlife health indicators. In SWAN-Aging, we will extend follow-up of the SWAN cohort into early old
age (66-75 years) and will prospectively link comprehensive longitudinal characterization of both the MT and
midlife health indicators to functioning and health across multiple domains in early old age, a pivotal time of
transition into old age when adverse changes in health and functioning begin to accumulate. The global
specific aims of this U19 application are to: 1) determine the impact of MT characteristics and trajectories of
midlife health indicators on the preservation of cognitive, physical, genitourinary, sexual, and psychosocial
function and sleep in early old age; 2) determine the impact of MT characteristics and trajectories of midlife
health indicators on risk of adverse health outcomes, including falls, osteoporosis and fractures, poor
cardiometabolic function, cardiovascular events and early mortality; 3) determine if racial/ethnic disparities in
health and functioning in early old age are attributable to midlife racial/ethnic differences in MT characteristics
and midlife health indicators; and 4) translate the SWAN and SWAN-Aging findings for women and their health
care providers. These aims will be achieved through three integrated scientific Projects that are organized
around key health domains (functioning, cardiometabolic health and musculoskeletal health) and linked by a
common focus on MT characteristics and midlife changes in health indicators as key exposures. The three
Projects will be supported by three Cores which will a) provide the necessary organizational infrastructure to
conduct this study and to disseminate results to the research and medical communities; b) conduct accurate,
high volume assays, adopting new methods as needed to provide state-of-the-art laboratory data, and c)
oversee the design and conduct of the core clinic visit, data collection and data management, and the creation
of the analytic datasets. SWAN-Aging will include one clinic visit and a National Death Index search to ensure
complete mortality ascertainment for the cohort. SWAN-Aging is uniquely positioned to fill important scientific
gaps in understanding of the impact of the MT and midlife indicators on women's health and functioning in
early old age and to facilitate the application of new knowledge to clinical practice. This study will provide
valuable insights into modifiable factors relevant to the design of future prevention and treatment programs.
项目总结
项目成果
期刊论文数量(0)
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SHERRI-ANN M BURNETT-BOWIE其他文献
SHERRI-ANN M BURNETT-BOWIE的其他文献
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{{ truncateString('SHERRI-ANN M BURNETT-BOWIE', 18)}}的其他基金
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
- 批准号:
10263894 - 财政年份:2020
- 资助金额:
$ 31.6万 - 项目类别:
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
- 批准号:
10292495 - 财政年份:2020
- 资助金额:
$ 31.6万 - 项目类别:
The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age
全国妇女健康研究 (SWAN):中年和更年期过渡对早年健康和功能的影响
- 批准号:
10471452 - 财政年份:2020
- 资助金额:
$ 31.6万 - 项目类别:
VITAMIN D DEFICIENCY: INSULIN RESISTANCE AND FGF-23
维生素 D 缺乏:胰岛素抵抗和 FGF-23
- 批准号:
7731274 - 财政年份:2008
- 资助金额:
$ 31.6万 - 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
- 批准号:
7433724 - 财政年份:2006
- 资助金额:
$ 31.6万 - 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
- 批准号:
7147855 - 财政年份:2006
- 资助金额:
$ 31.6万 - 项目类别:
VITAMIN D DEFICIENCY: INSULIN RESISTANCE AND FGF-23
维生素 D 缺乏:胰岛素抵抗和 FGF-23
- 批准号:
7607088 - 财政年份:2006
- 资助金额:
$ 31.6万 - 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
- 批准号:
7880829 - 财政年份:2006
- 资助金额:
$ 31.6万 - 项目类别:
Dietary and hormonal regulation of FGF-23 in humans
人类 FGF-23 的饮食和激素调节
- 批准号:
7647447 - 财政年份:2006
- 资助金额:
$ 31.6万 - 项目类别:
EFFECTS OF DIETARY PHOSPHATE ON THE REGULATION OF FGF-23
膳食磷酸盐对 FGF-23 调节的影响
- 批准号:
7205064 - 财政年份:2004
- 资助金额:
$ 31.6万 - 项目类别:
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