VITAMIN D DEFICIENCY: INSULIN RESISTANCE AND FGF-23

维生素 D 缺乏：胰岛素抵抗和 FGF-23

• 批准号: 7731274
• 负责人: SHERRI-ANN M BURNETT-BOWIE
• 金额: $ 10.44万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731274
• 关键词: Affect; Calcium; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Funding; Grant; Hormones; Institution; Insulin Resistance; Placebos; Prevention strategy; Randomized; Regulation; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Vitamin D; Vitamin D Deficiency; Vitamins; Week; improved; inorganic phosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data suggest that vitamin D deficiency (1) contributes to insulin resistance and (2) affects the regulation of a new phosphate-regulating hormone, FGF-23. We will test if treatment of vitamin D deficiency improves insulin resistance and increases FGF-23. Over 12 weeks, 100 healthy vitamin D deficient subjects will be randomly assigned to calcium 500mg BID and either vitamin D 50,000 IU QWEEK or placebo. If confirmed, these data would (1) argue that treatment of vitamin D deficiency could be used as a strategy for the prevention of diabetes mellitus and (2) add to the understanding of a new and important hormone.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 数据表明，维生素D缺乏症（1）有助于胰岛素耐药性，（2）会影响新的磷酸激素调节激素FGF-23。我们将测试维生素D缺乏症的治疗是否可以提高胰岛素抵抗并增加FGF-23。 在12周的时间里，将将100个健康的维生素D缺乏受试者随机分配到500mg钙的bid和维生素D 50,000 IU QWeek或安慰剂中。 如果得到确认，这些数据将（1）认为维生素D缺乏症的治疗可以用作预防糖尿病的策略，并且（2）增加了对新的重要激素的理解。