The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age

全国妇女健康研究（SWAN）：中年和更年期的影响 老年早期健康和功能的转变。行政补充 摘要 2019冠状病毒病（COVID-19）大流行极大地改变了我们的生活和互动方式。 除了在美国夺去超过22万人的生命和感染超过800万人之外， (US)迄今为止，还有数百万人因失业或经商而遭受经济损失; 孤独、焦虑或抑郁;没有接受或延误医疗护理。这一行政 补充天鹅老化：中年和更年期过渡对健康和功能的影响， Early Old Age（1U 19 AG 063720 - 01 A1）是对特别关注通知NOT-AG-20-022：NIA的回应 关于COVID-19的行政补充和修订补充的可用性。大流行 特别是与天鹅老龄化参与者有关，因为他们是高风险，潜在的高暴露， 根据年龄和居住地点，全国妇女健康研究（SWAN） 是一个多种族/民族的女性队列，年龄在42-52岁之间，随访超过25年， 经济紧张和压力，健康行为，认知和身体功能，以及精神和 身体健康天鹅老化将前瞻性地联系全面的纵向表征， 更年期过渡（MT）和中年健康指标，以功能和多个健康领域的早期老年人 年龄（65-75岁），包括认知障碍和认知下降，身体功能，心理 健康、睡眠、心血管和骨骼健康。计划于2021年7月开始的后续访问提供了一个 这是评价这一流行病对妇女的经济安全、获得 健康护理、认知和身体功能以及老年早期的身心健康。天鹅- 老龄化的总体目标是提高对妇女成功老龄化的理解。如果不抓紧时间- 关于COVID-19感染及其后果的敏感数据，SWAN-Aging将无法解释 大流行病对参与者健康和福祉的影响。这一行政补充旨在 评估感染和症状、社会和经济破坏以及延迟医疗对 老年早期健康和功能的多个方面。以前收集的大量纵向数据 将使我们能够a）说明个人特定的，大流行前的生物学，功能和健康轨迹， 在将COVID-19大流行的因果影响与老龄化分离时，以及B）描述风险和 对健康和功能的流行病相关影响的保护因素。它的目标是1）表征 COVID-19感染（血清阳性、症状和住院），并确定 大流行病对天鹅老龄妇女的健康和功能的影响; 2）确定大流行病的影响， 经济安全、社会参与、健康行为以及健康和功能方面的缓解努力 结果;以及3）确定与COVID-19相关的医疗延误对健康的影响。

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age. Administrative Supplement ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic, has dramatically changed the way we live and interact. In addition to claiming more than 220,000 lives and infecting more than 8 million people in the United States (US) to date, many more millions have suffered economically through job or business loss; suffered from social isolation, anxiety or depression; and have not received or delayed medical care. This administrative supplement to SWAN-Aging: The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age (1U19AG063720-01A1) is in response to the Notice of Special Interest NOT-AG-20-022: NIA Availability of Administrative Supplements and Revision Supplements on COVID-19. The pandemic is especially pertinent to SWAN-Aging participants as they are a high-risk, and potentially high-exposure, population given their age and residential locations. The Study of Women’s Health Across the Nation (SWAN) is a multi-racial/ethnic cohort of women, enrolled at age 42-52 and followed for over 25 years with longitudinal measures of economic strain and stress, health behaviors, cognitive and physical functioning, and mental and physical health. SWAN-Aging will prospectively link comprehensive longitudinal characterization of the menopause transition (MT) and midlife health indicators to functioning and multiple health domains in early old age (65-75 years), including cognitive impairment and cognitive decline, physical functioning, psychological well-being, sleep, and cardiovascular and bone health. A follow-up visit, planned to start July 2021, provides a unique opportunity to evaluate the longer-term impact of the pandemic on women’s economic security, access to health care, their cognitive and physical functioning, and physical and mental health in early old age. SWAN- Aging’s overall goal is to enhance understanding of successful aging in women. Without collecting time- sensitive data on COVID-19 infection and its consequences, SWAN-Aging will not be able to account for the impact of the pandemic on participants’ health and well-being. This administrative supplement is designed to evaluate the effect of infection and symptoms, social and economic disruption, and delayed medical care on multiple aspects of health and functioning in early old age. The wealth of previously collected longitudinal data will allow us to a) account for person-specific, pre-pandemic trajectories of biology, functioning, and health, when disentangling the causal impact of the COVID-19 pandemic from aging, and b) delineate risk and protective factors for pandemic-related effects on health and functioning. Its goals are 1) to characterize COVID-19 infection (seropositivity, symptoms, and hospitalizations) and determine longer-term effects of the pandemic on health and functioning in SWAN-Aging women; 2) to determine the effect of the pandemic and mitigation efforts on economic security, social engagement, health behaviors, and health and functioning outcomes; and 3) to determine the effect of COVID-19-related delays in receiving medical care on health.