The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age

全国妇女健康研究(SWAN)：中年和更年期的影响 关于老年早期健康和功能的转变。行政副刊 摘要 冠状病毒病2019年(新冠肺炎)大流行，极大地改变了我们的生活和互动方式。 除了夺走22万多人的生命，感染美国800多万人外， (美国)到目前为止，更多的数百万人因失业或商业损失而遭受经济损失；遭受社会痛苦 孤立、焦虑或抑郁；没有接受或延误医疗护理。这项管理工作 天鹅老化补充：中年和更年期转变对健康和功能的影响 早年(1U19AG063720-01A1)是对特别利益通知NOT-AG-20-022：NIA的回应 在新冠肺炎上提供行政补充和修订补充。大流行是 尤其与天鹅老龄化参与者有关，因为他们是高风险和潜在的高暴露， 考虑到他们的年龄和居住地点的人口。全国妇女健康研究(天鹅) 是一个多种族/民族的女性队列，年龄在42-52岁之间，并跟踪超过25年的纵向 经济紧张和压力、健康行为、认知和身体功能以及精神和心理的测量 身体健康。Swan-Aging将前瞻性地将全面的纵向特征 绝经过渡期(MT)与中年健康指标对早期老年人功能和多健康领域的影响 年龄(65-75岁)，包括认知障碍和认知衰退、身体功能、心理 健康、睡眠、心血管和骨骼健康。计划于2021年7月开始的后续访问提供了 评价这一大流行病对妇女经济安全、获取 在老年早期，儿童有权获得医疗保健、认知和身体功能以及身心健康。天鹅- 老龄化的总体目标是加强对女性成功老龄化的理解。如果不收集时间- 新冠肺炎感染及其后果的敏感数据，天鹅老龄化将无法解释 大流行对参与者的健康和福祉的影响。本行政副刊旨在 评估感染和症状、社会和经济中断以及延迟的医疗护理对 老年早期的健康和功能的多个方面。先前收集的大量纵向数据 将使我们能够a)解释特定于人的、大流行前的生物学、功能和健康的轨迹， 在将新冠肺炎大流行的因果影响与老龄化分开时，以及b)界定风险和 大流行对健康和功能影响的保护性因素。它的目标是1)刻画 新冠肺炎感染(血清阳性，症状和住院)，并确定长期影响 大流行对天鹅老龄妇女健康和功能的影响；2)确定大流行的影响和 缓解经济安全、社会参与、健康行为以及健康和功能方面的努力 结果：以及3)确定新冠肺炎相关就医延迟对健康的影响。

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age. Administrative Supplement ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic, has dramatically changed the way we live and interact. In addition to claiming more than 220,000 lives and infecting more than 8 million people in the United States (US) to date, many more millions have suffered economically through job or business loss; suffered from social isolation, anxiety or depression; and have not received or delayed medical care. This administrative supplement to SWAN-Aging: The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age (1U19AG063720-01A1) is in response to the Notice of Special Interest NOT-AG-20-022: NIA Availability of Administrative Supplements and Revision Supplements on COVID-19. The pandemic is especially pertinent to SWAN-Aging participants as they are a high-risk, and potentially high-exposure, population given their age and residential locations. The Study of Women’s Health Across the Nation (SWAN) is a multi-racial/ethnic cohort of women, enrolled at age 42-52 and followed for over 25 years with longitudinal measures of economic strain and stress, health behaviors, cognitive and physical functioning, and mental and physical health. SWAN-Aging will prospectively link comprehensive longitudinal characterization of the menopause transition (MT) and midlife health indicators to functioning and multiple health domains in early old age (65-75 years), including cognitive impairment and cognitive decline, physical functioning, psychological well-being, sleep, and cardiovascular and bone health. A follow-up visit, planned to start July 2021, provides a unique opportunity to evaluate the longer-term impact of the pandemic on women’s economic security, access to health care, their cognitive and physical functioning, and physical and mental health in early old age. SWAN- Aging’s overall goal is to enhance understanding of successful aging in women. Without collecting time- sensitive data on COVID-19 infection and its consequences, SWAN-Aging will not be able to account for the impact of the pandemic on participants’ health and well-being. This administrative supplement is designed to evaluate the effect of infection and symptoms, social and economic disruption, and delayed medical care on multiple aspects of health and functioning in early old age. The wealth of previously collected longitudinal data will allow us to a) account for person-specific, pre-pandemic trajectories of biology, functioning, and health, when disentangling the causal impact of the COVID-19 pandemic from aging, and b) delineate risk and protective factors for pandemic-related effects on health and functioning. Its goals are 1) to characterize COVID-19 infection (seropositivity, symptoms, and hospitalizations) and determine longer-term effects of the pandemic on health and functioning in SWAN-Aging women; 2) to determine the effect of the pandemic and mitigation efforts on economic security, social engagement, health behaviors, and health and functioning outcomes; and 3) to determine the effect of COVID-19-related delays in receiving medical care on health.