The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age

全国妇女健康研究 (SWAN)：中年和更年期过渡对早年健康和功能的影响

• 批准号: 10292495
• 负责人: SHERRI-ANN M BURNETT-BOWIE
• 金额: $ 19.67万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292495
• 关键词: 2019-nCoV; Address; Administrative Supplement; Age; Aging; American; Anxiety; Behavior; Biology; Blood Glucose; Blood Pressure; Businesses; COVID-19; COVID-19 mortality; COVID-19 pandemic; Cardiovascular system; Caring; Chronic Disease; Data; Diabetes Mellitus; Economics; Enrollment; Ethnic Origin; Event; Fright; Goals; Health; Health behavior; Health care facility; Home; Hospitalization; Impaired cognition; Infection; Link; Lipids; Location; Masks; Measures; Medical; Menopause; Mental Depression; Mental Health; Neighborhoods; Obesity; Occupations; Outcome; Participant; Personal Satisfaction; Persons; Physical Function; Population; Population Density; Preventive care; Provider; Race; Risk; Risk Factors; SARS-CoV-2 infection; Security; Serology; Social Distance; Social isolation; Social support; Socioeconomic Status; Stress; Study of Women' s Health Across the Nation; Symptoms; Time; United States; Virus; Visit; Well in self; Woman; bone health; cardiometabolism; cardiovascular health; cognitive function; cohort; design; experience; follow-up; health care availability; health care service utilization; health related quality of life; high risk; human old age (65+); interest; low socioeconomic status; middle age; multi-racial; optimism; pandemic disease; physical conditioning; prospective; protective factors; psychologic; racial and ethnic; resilience; response; screening; seropositive; sleep health; social; social engagement; symptomatic COVID-19; urgent care

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age. Administrative Supplement ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic, has dramatically changed the way we live and interact. In addition to claiming more than 220,000 lives and infecting more than 8 million people in the United States (US) to date, many more millions have suffered economically through job or business loss; suffered from social isolation, anxiety or depression; and have not received or delayed medical care. This administrative supplement to SWAN-Aging: The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age (1U19AG063720-01A1) is in response to the Notice of Special Interest NOT-AG-20-022: NIA Availability of Administrative Supplements and Revision Supplements on COVID-19. The pandemic is especially pertinent to SWAN-Aging participants as they are a high-risk, and potentially high-exposure, population given their age and residential locations. The Study of Women’s Health Across the Nation (SWAN) is a multi-racial/ethnic cohort of women, enrolled at age 42-52 and followed for over 25 years with longitudinal measures of economic strain and stress, health behaviors, cognitive and physical functioning, and mental and physical health. SWAN-Aging will prospectively link comprehensive longitudinal characterization of the menopause transition (MT) and midlife health indicators to functioning and multiple health domains in early old age (65-75 years), including cognitive impairment and cognitive decline, physical functioning, psychological well-being, sleep, and cardiovascular and bone health. A follow-up visit, planned to start July 2021, provides a unique opportunity to evaluate the longer-term impact of the pandemic on women’s economic security, access to health care, their cognitive and physical functioning, and physical and mental health in early old age. SWAN- Aging’s overall goal is to enhance understanding of successful aging in women. Without collecting time- sensitive data on COVID-19 infection and its consequences, SWAN-Aging will not be able to account for the impact of the pandemic on participants’ health and well-being. This administrative supplement is designed to evaluate the effect of infection and symptoms, social and economic disruption, and delayed medical care on multiple aspects of health and functioning in early old age. The wealth of previously collected longitudinal data will allow us to a) account for person-specific, pre-pandemic trajectories of biology, functioning, and health, when disentangling the causal impact of the COVID-19 pandemic from aging, and b) delineate risk and protective factors for pandemic-related effects on health and functioning. Its goals are 1) to characterize COVID-19 infection (seropositivity, symptoms, and hospitalizations) and determine longer-term effects of the pandemic on health and functioning in SWAN-Aging women; 2) to determine the effect of the pandemic and mitigation efforts on economic security, social engagement, health behaviors, and health and functioning outcomes; and 3) to determine the effect of COVID-19-related delays in receiving medical care on health.

全国妇女健康研究 (SWAN)：中年和更年期的影响 早年健康和功能的转变。行政补充 抽象的 2019 年冠状病毒病 (COVID-19) 大流行极大地改变了我们的生活和互动方式。 除了在美国夺走了超过22万人的生命并感染了超过800万人 （美国）迄今为止，还有数百万人因失业或生意损失而遭受经济损失；遭受社会 孤立、焦虑或抑郁；并且没有接受或延误医疗护理。本次行政 SWAN-Aging 的补充：中年和更年期过渡对健康和功能的影响 早年 (1U19AG063720-01A1) 是对特殊利益通知 NOT-AG-20-022 的回应：NIA 有关 COVID-19 的行政补充和修订补充的可用性。此次疫情是 尤其与 SWAN-Aging 参与者相关，因为他们是高风险且潜在的高暴露人群， 考虑到年龄和居住地点的人口。全国妇女健康研究 (SWAN) 是一个多种族/民族的女性队列，在 42-52 岁之间入组，并进行了超过 25 年的纵向跟踪研究。 经济紧张和压力、健康行为、认知和身体功能以及精神和心理方面的衡量标准 身体健康。 SWAN-Aging 将前瞻性地将综合纵向特征联系起来 更年期过渡 (MT) 和中年健康指标对早期老年人的功能和多个健康领域的影响 年龄（65-75岁），包括认知障碍和认知衰退、身体机能、心理 健康、睡眠、心血管和骨骼健康。计划于 2021 年 7 月开始的后续访问提供了 评估这一流行病对妇女经济安全、获得机会的长期影响的独特机会 保健、他们的认知和身体功能以及早年的身心健康。天鹅- 《老龄化》的总体目标是增强女性对成功老龄化的理解。无需收集时间—— 有关 COVID-19 感染及其后果的敏感数据，SWAN-Aging 将无法解释 大流行对参与者健康和福祉的影响。本行政补充的目的是 评估感染和症状、社会和经济混乱以及医疗护理延迟对患者的影响 早年健康和功能的多个方面。先前收集的大量纵向数据 将使我们能够a）解释特定于个人的、大流行前的生物学、功能和健康轨迹， 在理清 COVID-19 大流行与老龄化之间的因果影响时，b) 描述风险和 大流行相关的健康和功能影响的保护因素。其目标是 1) 表征 COVID-19 感染（血清阳性、症状和住院治疗）并确定其长期影响 流行病对 SWAN 老年妇女健康和功能的影响； 2）确定大流行的影响 经济安全、社会参与、健康行为以及健康和功能方面的缓解努力 结果； 3) 确定与 COVID-19 相关的延迟接受医疗服务对健康的影响。