Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study Cohort

环境对北部平原安全通道研究队列儿童健康结果的影响

• 批准号: 10442792
• 负责人: Amy J Elliott
• 金额: $ 10.05万
• 依托单位: AVERA MCKENNAN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10442792
• 关键词: Age; Alaska Native; Alcohols; Allergens; Allergic; American Indians; Area; Asthma; Attention; Behavioral; Breathing; Child; Child Health; Childhood; Cognitive; Cohort Studies; Complex; Consent; DNA Methylation; Data; Data Collection; Data Element; Data Set; Development; Electroencephalography; Elements; Emergency department visit; Ensure; Environmental Exposure; Exposure to; Family; Fetal Alcohol Exposure; Foundations; Future; Goals; Growth; Health; Hearing; Hospitalization; Individual; Infant; Infrastructure; Inhalant dose form; Intervention; Life; Measures; Mediating; Mediator of activation protein; National Institute of Child Health and Human Development; Neuraxis; Outcome; Participant; Pharmaceutical Preparations; Phase; Phenotype; Physiology; Population; Procedures; Protocols documentation; Recording of previous events; Research Personnel; Rest; Risk; Rural; School-Age Population; Sensory; Site; Sleep; Smoking; Stress; Sudden infant death syndrome; Symptoms; Testing; Tobacco; Training; Wheezing; Work; Youth; adverse outcome; airway inflammation; alcohol exposure; behavioral outcome; cohort; community engagement; dosage; early childhood; early life exposure; environmental stressor; executive function; feasibility testing; fetal; fungus; high risk population; indexing; infancy; innovation; neurodevelopment; neurodevelopmental effect; neurophysiology; non-Native; northern plains; patient engagement; postnatal; prenatal; prenatal exposure; pulmonary function; recruit; response; rural Americans; social; stillbirth; tobacco smoke exposure

Project Summary/Abstract The overarching premise of this proposal is that the extant and proposed cohorts (n>4400), infrastructure, and investigative team of PASS-ECHO are uniquely poised to answer questions relating to the impact of prenatal and early childhood environmental exposures on later health outcomes. To accomplish this objective, the study will build upon the successful study infrastructure established through the Prenatal Alcohol in SIDS and Stillbirth (PASS) Network (NICHD U02-HD045935) and will utilize this unique cohort to provide a wealth of prenatal and infant data that can expand the capability of the ECHO study in areas of neurodevelopment, neurophysiology, and asthma, particularly among rural and American Indian youth. The PASS-ECHO investigative team has a proven track record in conducting complex and high quality studies while maintaining longitudinal participant and community engagement in the region. Complementary to the common protocol, the PASS-ECHO cohort will examine in-depth data concurrent to individual-, family-, and social-level factors .While this proposal focuses on neurodevelopmental and asthma outcomes, the PASS-ECHO cohort is capable of including additional measures to provide additional data for the other ECHO focus areas. The PASS-ECHO investigators, infrastructure, and cohort have the capacity to contribute significantly to meet the overarching goal of ECHO.

项目概要/摘要 该提案的总体前提是现有和拟议的队列（n>4400）、基础设施、 PASS-ECHO 和调查团队以独特的方式回答与影响相关的问题 产前和儿童早期的环境暴露对以后的健康结果的影响。为了实现这一目标， 该研究将建立在通过小岛屿发展中国家产前酒精建立的成功研究基础设施的基础上 和死产 (PASS) 网络 (NICHD U02-HD045935)，并将利用这个独特的群体提供丰富的 产前和婴儿数据可以扩展 ECHO 研究在神经发育领域的能力， 神经生理学和哮喘，特别是在农村和美国印第安青年中。 PASS-ECHO 调查团队在进行复杂和高质量的研究方面拥有良好的记录，同时保持 该地区的纵向参与者和社区参与。作为通用协议的补充， PASS-ECHO 队列将检查与个人、家庭和社会层面因素同时发生的深入数据。 该提案重点关注神经发育和哮喘结果，PASS-ECHO 队列能够 包括为其他 ECHO 重点领域提供额外数据的额外措施。 PASS-ECHO 研究人员、基础设施和队列有能力为满足总体目标做出重大贡献 回声的目标。