2/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes

2/5 物质暴露和早年不幸对儿童健康发展和结果的累积风险

基本信息

  • 批准号:
    9899486
  • 负责人:
  • 金额:
    $ 25.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-30 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

PROJECTSUMMARY / DESCRIPTION How do in utero opioid exposure and early adversity affect a child's neurodevelopmental and health outcomes? The simplicity of this question masks the complex and multifaceted nature of human neurodevelopment, and the variety of environmental influences that can exacerbate or moderate the effects of in utero substance exposure. From conception to age 10, our brain undergoes remarkable structural and functional change. Processes including myelination and synaptogenesis are at their peak throughout this age span, contributing to the emergence of nearly all cognitive and behavioral skills, and responsive to both early substance exposures and environmental stimuli. In the context of fetal opioid exposure, this often co-occurs with other maternal substance use (alcohol, tobacco, marijuana), as well as related pre- and post-natal factors including maternal mental health concerns, supportive or adverse family environments, low socioeconomic status (SES), inter-partner violence, and caregiving quality and quantity. Despite increased efforts to understand the neurodevelopmental sequela of in utero opioid and other substance exposure on long-term behavioral, cognitive, and societal outcomes, important questions remain, specifically, 1. How is brain growth is disrupted by fetal substance and related pre and post-natal exposures; and 2. How are these disrupted growth patterns causally related to later cognitive and behavioral outcomes? This proposal seeks to formulate our approach to addressing these key questions, and decipher the individual and cumulative effect of these intertwined pre- and post-natal exposures on child neurodevelopment. By bringing together leading experts in child development and adversity, pediatric neuroimaging, maternal, fetal, and child abuse medicine, longitudinal and functional statistics, and public health, strategically located US states and counties hardest hit by the current opioid crisis, we will articulate our vision of the larger HEALthy Brain & Child Development study, and lay the foundation for our participation in three incremental steps. First, we will address the legal, ethical, and mother-child care and support concerns implicit in this study by leveraging our team's past experience in family adversity, child abuse, and fetal substance exposure research. Next, we will integrate across our areas of neuroimaging expertise to develop, implement, and harmonize a multi-modal MRI and EEG protocol to assess maturing brain structure, function, and connectivity. This neuroimaging protocol will be paired with extensive neurocognitive, sociodemographic, physical health, family and medical history, anthropometric, and biospecimen data collection to quantify the individual, cumulative, and interactive effects of a child's substance and environment on their overall health and neurodevelopment. Finally, we will develop and test advanced statistical approaches to model and analyze this multidimensional and longitudinal data, taking into account the likely sparse and unbalanced nature of the measurements. Together, these steps lay the foundation for a broad and large-scale study to examine the impact of exposure to substances and early adversity on a child's neural, physical, and behavioral development.
项目摘要/描述

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Amy J Elliott其他文献

Association of maternal fish consumption and strongω/strong-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis
孕期母亲鱼类摄入量及ω-3补充剂的使用与儿童自闭症相关结局的关联:一项队列联合分析结果
  • DOI:
    10.1016/j.ajcnut.2024.06.013
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Kristen Lyall;Matt Westlake;Rashelle J Musci;Kennedy Gachigi;Emily S Barrett;Theresa M Bastain;Nicole R Bush;Claudia Buss;Carlos A Camargo;Lisa A Croen;Dana Dabelea;Anne L Dunlop;Amy J Elliott;Assiamira Ferrara;Akhgar Ghassabian;James E Gern;Marion E Hare;Irva Hertz-Picciotto;Alison E Hipwell;Christine W Hockett;S Swan
  • 通讯作者:
    S Swan

Amy J Elliott的其他文献

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{{ truncateString('Amy J Elliott', 18)}}的其他基金

Maternal American-Indian Rural Community Health (MARCH)
美国-印度孕产妇农村社区健康(三月)
  • 批准号:
    10748656
  • 财政年份:
    2023
  • 资助金额:
    $ 25.18万
  • 项目类别:
Community Partners Component
社区合作伙伴组件
  • 批准号:
    10748660
  • 财政年份:
    2023
  • 资助金额:
    $ 25.18万
  • 项目类别:
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
南达科他州儿科临床试验网络 (SoDakPCTN)
  • 批准号:
    10923168
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
南达科他州儿科临床试验网络 (SoDakPCTN)
  • 批准号:
    10625726
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
南达科他州儿科临床试验网络 (SoDakPCTN)
  • 批准号:
    10242215
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
南达科他州儿科临床试验网络 (SoDakPCTN)
  • 批准号:
    10474477
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
南达科他州儿科临床试验网络 (SoDakPCTN)
  • 批准号:
    10064263
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
2/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes
2/5 物质暴露和早年不幸对儿童健康发展和结果的累积风险
  • 批准号:
    10017367
  • 财政年份:
    2019
  • 资助金额:
    $ 25.18万
  • 项目类别:
2/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes
2/5 物质暴露和早年不幸对儿童健康发展和结果的累积风险
  • 批准号:
    10199299
  • 财政年份:
    2019
  • 资助金额:
    $ 25.18万
  • 项目类别:
Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study Cohort
环境对北部平原安全通道研究队列儿童健康结果的影响
  • 批准号:
    10442792
  • 财政年份:
    2016
  • 资助金额:
    $ 25.18万
  • 项目类别:

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Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
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The affect of Age related hearing loss for cognitive function
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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