The development of subnetworks of the TRN

TRN子网的发展

• 批准号: 10441609
• 负责人: Ubadah Sabbagh
• 金额: $ 8.91万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441609
• 关键词: Address; Architecture; Area; BRAIN initiative; Biological Clocks; Biology; Brain; Brain region; Cell Nucleus; Cells; Characteristics; Communities; Data; Data Set; Development; Disease; Dorsal; Extracellular Matrix; Eye; Eye Movements; Eye diseases; Fiber; Foxes; Functional disorder; Goals; Health; Human; Image; Immunohistochemistry; In Situ Hybridization; Individual; Injury; Interneurons; Jet Lag Syndrome; Knowledge; Label; Laboratories; Lateral Geniculate Body; Lead; Light; Mediating; Medicine; Mental Depression; Mentors; Methods; Molecular; Molecular Genetics; Molecular Neurobiology; Moods; National Eye Institute; Natural regeneration; Nerve Regeneration; Nervous system structure; Neurons; Neurosciences; Pattern; Positioning Attribute; Postdoctoral Fellow; Process; Proteome; Proteomics; Publications; Reporter; Research; Research Personnel; Research Project Grants; Retina; Retinal Ganglion Cells; Role; Sleep Disorders; Spatial Distribution; Structure; Subthalamic structure; System; Technical Expertise; Testing; Thalamic structure; Training; Transgenic Organisms; Translational Research; United States National Institutes of Health; Universities; Ursidae Family; Viral; Virginia; Vision; Visual; Visual system structure; Work; cell type; circadian; circadian pacemaker; developmental neurobiology; doctoral student; information processing; innovation; interdisciplinary approach; meetings; neural circuit; neurochemistry; neurodevelopment; novel; optic nerve regeneration; postnatal; pre-doctoral; programs; regenerative approach; regenerative therapy; restoration; retinogeniculate; segregation; single-cell RNA sequencing; tenure track; therapy development; tool; transcriptome; transcriptomics; vision development; visual information; visual motor

PROJECT SUMMARY Our relationship with the visual world is heavily dependent on our ability to receive and process light coming into the eye. A portion of that light-derived information is needed for many non-image-forming visual functions like programming our biological clocks, controlling eye movement, and influencing mood. A major region of the brain which receives this non-image-forming visual information is located in the ventral thalamus and known as the ventral lateral geniculate nucleus (vLGN). Although the vLGN has connections with downstream regions involved in important functions, including visuomotor function, circadian photoentrainment, and vestibular function, it has not been well-studied. One reason for this significant gap in knowledge is that very little is known about funda- mental characteristics of vLGN, particularly with respect to its cellular and molecular landscape, thus making it technically challenging to develop tools to answer outstanding questions about its role in visual information pro- cessing. This study is motivated by the need to characterize the molecular architecture of vLGN, and to identify the neurons which form connections with retinal fibers. This project directly aligns with the BRAIN Initiative and the NIH's Blueprint Program by expanding fundamental understanding of neuroscience using innovative re- search methods to characterize cell types in the nervous system and mapping connected neurons in the brain. The results of this work will significantly impact the field and generate a deeper understanding of a visual region of the brain which receives, processes, and transmits non-image-forming visual information.

项目总结