Population Research and Methods (RC-PRM)

项目概要/摘要 人口研究和方法核心（RC-PRM） 人口研究和方法核心（RC-PRM）采用多管齐下的方法来支持西奈山老年美国独立中心（MS-OAIC）的研究人员，他们面临着老年人阿尔茨海默病和相关痴呆症（ADRD）和其他严重疾病研究中出现的方法和分析问题。这个核心一直是非常富有成效的，通过我们的研究咨询计划，研究方法培训计划和指导，所有支持人口为基础的研究的一个过度的主题，为众多的OAIC调查人员提供支持。对于这一申请，我们召集了一批专家，其中一些人曾担任过顾问，一些人是新来的，他们具有广泛的知识和专业知识，可以作为调查人员的潜在顾问。我们增加了支持痴呆症研究的新举措，包括与痴呆症研究领域的领导者顾问合作，以及新的培训模块，重点是同意能力，工具选择，受试者保留，评估措施和结果，以及ADRD队列的纵向分析。我们扩大了我们 培训教师和硕士培训的分析人员，重点是观察研究方法，并增加了新的培训和支持实施科学。资源和专业知识将以各种方式提供，并贯穿研究过程的所有阶段-从研究设计到结果的解释和呈现。RC-PRM将为四个拟议的试点和探索性研究以及一个外部项目提供分析支持，每个项目都涉及OAIC的研究目标。此外，RC-PRM将开展一个发展项目，采用潜在类增长模型，为ADRD患者探索繁重的治疗轨迹，为未来探索痴呆症，功能和多功能障碍的交叉点奠定基础。RC-PRM的具体目标是：1）为OAIC调查人员提供严格的方法和分析支持; 2）应用先进的研究和统计方法（例如，潜在类别分析、倾向分数、工具变量估计、竞争风险分析等），但不常用于老龄化相关研究; 3）与REC和PESC密切合作，确保初级教师获得研究方法培训，以提高他们现有的知识和专业知识，并促进他们的独立性; 4）通过对教师和分析人员进行专门针对基于人口的研究方法的培训，为基于人口的研究开发基础设施; 5）将我们的咨询计划和研究方法培训扩展到痴呆症和实施科学领域。通过与专家就一系列主题进行磋商，解决重病老年人研究中遇到的方法和统计问题以及研究基础设施的发展，该核心旨在提高老年姑息治疗研究的严谨性，并支持未来的老年姑息治疗研究工作。

PROJECT SUMMARY/ABSTRACT Population Research and Methods Core (RC-PRM) The Population Research and Methods Core (RC-PRM) employs a multi-pronged approach to support Mount Sinai Older American Independence Center (MS-OAIC) investigators confronted with methodological and analytic issues that occur in the study of older adults with Alzheimer’s Disease and Related Dementias (ADRD) and other serious illness. This core has been highly productive in providing support for numerous OAIC investigators through our research consultancy program, research methods training program, and mentoring, all with an over-arching theme of supporting population-based research. For this application, we have assembled a cadre of experts, some who have served as past consultants and some who are new, with a broad range of knowledge and expertise to serve as potential consultants to investigators. We have added new initiatives to support dementia research including collaboration with consultants who are leaders in dementia research, and new training modules focusing on capacity for consent, instrument selection, subject retention, caregiving measures and outcomes, and longitudinal analysis of cohorts with ADRD. We have expanded our training for both faculty and master’s trained analytic staff, focusing on observational research methods, and have added new training and support in implementation science. Resources and expertise will be provided in a variety of ways and throughout all phases of the research process - from study design to interpretation and presentation of findings. The RC-PRM will provide analytic support for four proposed pilot and exploratory studies and one external project, each of which address the research goals of the OAIC. In addition, RC-PRM will conduct a developmental project employing latent class growth modeling to explore burdensome treatment trajectories for those with ADRD laying the foundation for future work exploring the intersection of dementia, function, and multimorbidity on burdensome treatments from dementia diagnosis to death. The RC-PRM specific aims are: 1) To provide rigorous methodological and analytic support to OAIC investigators; 2) To apply advanced research and statistical methodology (e.g., latent class analysis, propensity scores, instrumental variable estimation, competing risk analysis) used in other fields but not commonly applied to aging-related research; 3) To collaborate closely with the REC and PESC to ensure that junior faculty obtain research methods training to advance their current knowledge and expertise and to promote their independence; 4) To develop infrastructure for population-based research through faculty and analytic staff training specific to population-based research methods; and 5) To expand our consultancy program and research methods training to the areas of dementia and implementation science. Through consultations with experts on a range of topics addressing the methodological and statistical issues encountered in the study of seriously ill older adults and the development of research infrastructure, this Core aims to advance the rigor of geriatric palliative care research and support future geriatric palliative care research endeavors.