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Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes

Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes
羊毛硫抗生素生物合成和定制酶的机理研究
批准号：
10441524
负责人：
Satish K Nair
金额：
$38.24万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-02-01 至 2024-06-30
来源：
https://reporter.nih.gov/project-details/10441524
关键词：
AcidsAddressAnabolismAnti-Bacterial AgentsAntibioticsAntiviral AgentsBacteriaBiochemicalBiologicalChemistryComplexCross-Linking ReagentsCryoelectron MicroscopyCrystallizationCyclizationDataDehydrationElectronsEnzymatic BiochemistryEnzymesGlutamic Acid-Specific tRNAHandHydro-LyasesKnowledgeLigaseLipidsMethodologyMicroscopicModernizationModificationMolecularMultiprotein ComplexesMutationN-terminalNatural ProductsNegative StainingNisinPeptidesPhosphotransferasesPost-Translational Protein ProcessingProcessProductionPropertyProtein KinaseProteinsReactionResearchRibonucleoproteinsRibosomesRouteSchemeStructureTestingTherapeuticTransfer RNAUrsidae FamilyWorkbasebioactive natural productscatalystdrug discoverydrug productionimproved functioninglanthioninescaffoldsmall moleculestructural biologysuccesssynthetic biologythioether

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中文摘要
翻译
项目摘要/摘要 抗生素是由核糖体合成的，经翻译后修饰的多肽是天然的 产品。将多肽底物转化为受限制的生物合成酶 抗生素还没有被很好地理解，特别是在底物识别方面。 在这里，我们试图对以下几个方面进行生化和结构生物学研究 这些酶和解决有关底物识别和底物的问题 宽容。我们预计，这项工作不仅对发现 新化合物，但能够生产任何基于多肽的化合物 结构。
英文摘要
Project Summary/Abstract Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products. The biosynthetic enzymes that convert peptide substrates into constrained antibiotics are not well understood, especially with regards to substrate recognition. Here, we seek to carry out biochemical, and structural biological studies on several of these enzymes and address questions regarding substrate recognition, and substrate tolerance. We anticipate that this work will be of use not only towards the discovery of new compounds but to enable the production of peptide-based compounds of any structure.
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会议论文
Structural Biological Studies of Thipeptide Biosynthesis and Engineering
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery.
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery
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