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Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes

Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes
羊毛硫抗生素生物合成和定制酶的机理研究
批准号：
10783625
负责人：
Satish K Nair
金额：
$9.99万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-02-01 至 2024-06-30
来源：
https://reporter.nih.gov/project-details/10783625
关键词：
AddressAntibioticsAntiviral AgentsBiochemicalBiologicalEnzymesKnowledgePeptidesProductionPropertyResearchRibosomesStructureTherapeuticWorkdrug productionfunctional improvementpeptide natural products

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中文摘要
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英文摘要
Project Summary/Abstract Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products. The biosynthetic enzymes that convert peptide substrates into constrained antibiotics are not well understood, especially with regards to substrate recognition. Here, we seek to carry out biochemical, and structural biological studies on several of these enzymes and address questions regarding substrate recognition, and substrate tolerance. We anticipate that this work will be of use not only towards the discovery of new compounds but to enable the production of peptide-based compounds of any structure.
期刊论文(11)
专著(0)
科研奖励(0)
会议论文
Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products.
DOI： 10.1021/jacs.6b12872
发表时间： 2017-03-01
期刊： Journal of the American Chemical Society
影响因子： 15
作者： [Sardar D, Hao Y, Lin Z, Morita M, Nair SK, Schmidt EW]
通讯作者： Schmidt EW
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products.
DOI： 10.1016/j.cbpa.2022.102214
发表时间： 2022-12
期刊： Current opinion in chemical biology
影响因子： 7.8
作者： []
通讯作者：
YcaO-mediated ATP-dependent peptidase activity in ribosomal peptide biosynthesis.
核糖体肽生物合成中 YcaO 介导的 ATP 依赖性肽酶活性。
DOI： 10.1038/s41589-022-01141-0
发表时间： 2023
期刊： Nature chemical biology
影响因子： 14.8
作者： [Zheng,Yiwu, Nair,SatishK]
通讯作者： Nair,SatishK
Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa.
DOI： 10.1016/j.chembiol.2008.08.011
发表时间： 2008-10-20
期刊： Chemistry & biology
影响因子： --
作者： [Rubin-Pitel SB, Zhang H, Vu T, Brunzelle JS, Zhao H, Nair SK]
通讯作者： Nair SK
共 9 条
    Structural Biological Studies of Thipeptide Biosynthesis and Engineering
    Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery
    Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery.
    Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery
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