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Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes

Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes
羊毛硫抗生素生物合成和定制酶的机理研究
批准号：
10647689
负责人：
Satish K Nair
金额：
$29.15万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-02-01 至 2024-06-30
来源：
https://reporter.nih.gov/project-details/10647689
关键词：
AcidsAddressAnabolismAnti-Bacterial AgentsAntibioticsAntiviral AgentsBacteriaBindingBiochemicalBiologicalChemistryComplexCross-Linking ReagentsCryoelectron MicroscopyCyclizationDataDehydrationElectronsEnzymatic BiochemistryEnzymesGlutamic Acid-Specific tRNAHandHydro-LyasesKnowledgeLigaseLipidsMethodologyMicroscopicModernizationModificationMolecularMultiprotein ComplexesMutationN-terminalNegative StainingNisinPeptidesPhosphotransferasesPost-Translational Protein ProcessingProcessProductionPropertyProtein KinaseProteinsReactionResearchRibonucleoproteinsRibosomesRouteSchemeStructureSubstrate InteractionTestingTherapeuticTransfer RNAWorkbioactive natural productscatalystdrug discoverydrug productionfunctional improvementlanthioninepeptide natural productsscaffoldsmall moleculestructural biologysuccesssynthetic biologythioether

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Project Summary/Abstract Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products. The biosynthetic enzymes that convert peptide substrates into constrained antibiotics are not well understood, especially with regards to substrate recognition. Here, we seek to carry out biochemical, and structural biological studies on several of these enzymes and address questions regarding substrate recognition, and substrate tolerance. We anticipate that this work will be of use not only towards the discovery of new compounds but to enable the production of peptide-based compounds of any structure.
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Structural Biological Studies of Thipeptide Biosynthesis and Engineering
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery.
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery
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