Flexible Piezoelectric Array for Cardiovascular MonitoringDuring Cardiac Arrest

用于心脏骤停期间心血管监测的柔性压电阵列

• 批准号: 10440514
• 负责人: Xiaojing Zhang
• 金额: $ 19.11万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440514
• 关键词: Algorithms; Arteries; Benchmarking; Biosensing Techniques; Blood Pressure; Blood Pressure Monitors; Blood flow; Cardiopulmonary Resuscitation; Cardiovascular Physiology; Cardiovascular system; Caring; Carotid Arteries; Clinical; Complex; Consumption; Coupled; Couples; Data; Deposition; Detection; Development; Device Designs; Devices; Electrocardiogram; Electrodes; Elements; Equation; Feedback; Film; First Aid; Goals; Harvest; Heart Arrest; Human; Individual; Ink; Liquid substance; Measurement; Measures; Methods; Modeling; Monitor; Nanostructures; Noise; Outcome; Output; Pattern; Performance; Photoplethysmography; Physiologic pulse; Polymers; Printing; Property; Protocols documentation; Pulse Pressure; Pulse Rates; Research; Research Personnel; Signal Transduction; Skin; Sphygmomanometers; Structure; System; Techniques; Technology; Testing; Thinness; Time; Training; Work; base; brachial artery; data-driven model; detection method; falls; femoral artery; first responder; flexibility; human subject; improved; mechanical properties; nanofiber; novel; out-of-hospital cardiac arrest; polyvinylidene fluoride; pressure; pressure sensor; pulse pressure wave; radial artery; random forest; sensor; spatiotemporal; standard measure; wearable device

Project Summary In situations of out of hospital cardiac arrest, it is critical to quickly detect the performance of adequate cardiopulmonary resuscitation (CPR) through clinically acceptable pulse rate and blood pressure (BP). However, the detection of adequate CPR can be difficult for someone not trained in first aid. Currently the standard for measuring BP noninvasively is using cuff-based oscillometeric approaches. Attempts at developing these into wearable devices for automated and continuous measurements have proven difficult and so researchers have looked at other methods. However, these methods have not met the criteria for flexibility, accuracy, and low power consumption. This project aims to develop a flexible patch for accurate detection of pulse rate and blood pressure superficially through the radial, brachial, carotid, and/or femoral arteries. Piezoelectric polymers, are inherently flexible and have been used in many applications for pressure sensing, offering great potential for use as a patch-like sensor for monitoring of cardiovascular function. However, in the standard form, the material is not sensitive enough to accurately detect blood pressure. In our lab we have developed a core-shell nanofiber structure of conductive and piezoelectric nanofibers, respectively. The core-shell nanostructure shows a 4.5 times improvement in pressure sensitivity when compared to standard piezoelectric nanofibers and a nearly 40 times improvement when compared to piezoelectric polymer thin films. This improvement in pressure sensitivity should allow for a wearable device composed of these materials to exceed the necessary 35 dB signal to noise ratio required for the accurate detection of pulse wave velocity, a cardiovascular parameter used to determine blood pressure. Coupled with inkjet printing patterning techniques of conductive polymers developed in our lab, we propose to fabricate a novel core-shell nanofiber piezoelectric array in a wearable patch form for cardiovascular monitoring. In order to test this piezoelectric array and develop data-driven algorithms for the detection of blood pressure, testing will occur on a controllable simulated cardiovascular system capable of replicating a human’s diastolic and systolic blood pressures, pulse rates, and arterial mechanical properties. The blood pressure attainable by the simulated system falls within the AAMI standard benchmark for accuracy and precision for noninvasive blood pressure monitoring of 5 ± 8 mmHg. We will train various regression models using the data generated from this system to relate the detected pulse wave velocities to blood pressure and we will compare the outcomes to commonly used correlation equations. We propose that the fabrication methods we will develop, when coupled together with data-driven algorithms, will allow for the development of a low- power, flexible patch, capable of detecting pulse rate and blood pressure, giving feedback on the adequacy of CPR.

项目概要 在院外心脏骤停的情况下，快速检测足够的性能至关重要 通过临床可接受的脉率和血压 (BP) 进行心肺复苏 (CPR)。然而， 对于没有接受过急救培训的人来说，进行适当的心肺复苏可能很困难。目前的标准为 无创测量血压是使用基于袖带的示波法。尝试将这些发展成为 事实证明，用于自动连续测量的可穿戴设备很困难，因此研究人员 看了其他方法。然而，这些方法还没有达到灵活性、准确性和低效率的标准。 功耗。该项目旨在开发一种灵活的贴片，用于准确检测脉率和血液 表面压力通过桡动脉、肱动脉、颈动脉和/或股动脉。压电聚合物是 固有的灵活性，已被用于许多压力传感应用，提供了巨大的使用潜力 作为用于监测心血管功能的贴片式传感器。然而，在标准形式中，材料是 不够灵敏，无法准确检测血压。在我们的实验室中，我们开发了一种核壳纳米纤维 分别是导电纳米纤维和压电纳米纤维的结构。核壳纳米结构的比值为 4.5 与标准压电纳米纤维相比，压力灵敏度提高了近 40 倍 与压电聚合物薄膜相比，性能提高了数倍。压力灵敏度的改善 应允许由这些材料组成的可穿戴设备超过必要的 35 dB 信噪比 准确检测脉搏波速度所需的比率，脉搏波速度是用于确定的心血管参数 血压。结合我们实验室开发的导电聚合物喷墨印刷图案化技术， 我们建议以可穿戴贴片的形式制造一种新型核壳纳米纤维压电阵列，用于 心血管监测。为了测试该压电阵列并开发数据驱动算法 检测血压，测试将在一个可控的模拟心血管系统上进行，该系统能够 复制人类的舒张压和收缩压、脉搏率和动脉力学特性。这 模拟系统可达到的血压符合 AAMI 标准基准的准确性和 无创血压监测精度为 5 ± 8 mmHg。我们将训练各种回归模型 使用该系统生成的数据将检测到的脉搏波速度与血压联系起来，我们 将结果与常用的相关方程进行比较。我们建议制造方法 我们将开发，当与数据驱动的算法结合在一起时，将允许开发一个低 功率，柔性贴片，能够检测脉搏率和血压，就是否充足提供反馈 心肺复苏。

项目成果

Method for Inkjet-printing PEDOT:PSS polymer electrode arrays on piezoelectric PVDF-TrFE fibers.

• DOI: 10.1109/jsen.2021.3071321
• 发表时间: 2021-12
• 期刊: IEEE sensors journal
• 影响因子: 4.3
• 作者: Closson A;Richards H;Xu Z;Jin C;Dong L;Zhang JXJ
• 通讯作者: Zhang JXJ

Implantable Cardiac Kirigami-Inspired Lead-Based Energy Harvester Fabricated by Enhanced Piezoelectric Composite Film.

• DOI: 10.1002/adhm.202002100
• 发表时间: 2021-04
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Xu Z;Jin C;Cabe A;Escobedo D;Gruslova A;Jenney S;Closson AB;Dong L;Chen Z;Feldman MD;Zhang JXJ
• 通讯作者: Zhang JXJ