Brain, Immunology and Glia Training Program

项目摘要 弗吉尼亚大学（UVA）的脑免疫学和神经胶质细胞培训计划（BGTP）将建立在 神经免疫学和神经胶质研究的现有优势，以及自2005年以来一直存在的规划， 2012年，脑免疫学和神经胶质（BIG）中心成立。BGTP汇集了20个 来自八个不同部门的导师，旨在提供跨学科的培训， 发现并培养一代研究人员，他们具有独特的能力来解决研究问题 出现在神经科学和免疫学的交界处。资金要求支持两个博士预科 每年培训一名学员，为期两年，通常是在研究生培训的第三和第四年。的20 导师每年的直接费用共计近1 100万美元，资金充足。一般的导师 在过去的十年中，超过九个博士前和博士后研究生。助理教授被列为初级 导师将需要高级BIGTP教师担任学员的共同导师。正式的导师培训是 所有BIGTP导师的要求。学员将参加动态的大研究进展研讨会， 每周举行。学员还将通过BIG Neuro系列研讨会接触到该领域的领导者。年度 务虚会将侧重于学员的发展，审查计划，并将允许学员与成员互动 邀请BIGTP外部咨询委员会成员作为主旨发言人。学员的量化素养 将通过专门为学员设计的量化扫盲系列来开发和支持， 涉及实验设计、再现性、功效分析、统计分析、 重要的是，Marieke Jones博士指导编程和统计分析方面的必修课程。 并将直接得到BGTP活动的支持和参与，提供指导和支持的连续性 为实习生在博士前学习期间提供。BIGTP将由现任和前任学员进行评估， 项目导师和高素质的外部咨询委员会成员。博士前培训生， BGTP导师实验室在大约5.25年的时间内完成了学位， 平均4.9篇出版物和1.7篇第一作者出版物，包括：Nature，Cell，Nature Neuroscience，Science Translational Medicine，Immunity，Neuron，PNAS，Science Advances and Nature 通讯目前和过去的受训人员得到了国家卫生研究院赞助的个人奖学金的支持， NSF和UVA。重要的是，97%的受训人员留在科学相关领域，74%的人继续完成进一步的学习。 训练BGTP领导层和导师了解多样性的重要性，这对 培训计划的发展和壮大。BIGTP对多样性的承诺得到了证明 通过该计划的管理和计划活动的包容性。国家卫生研究院的实施- 赞助的T32培训计划将使弗吉尼亚大学现有的优势和编程得以加强和扩大 在一个新兴的研究领域为博士前学员提供无与伦比的培训。

PROJECT SUMMARY The Brain Immunology ang Glia Training Program (BIGTP) at the University of Virginia (UVA) will build on existing strengths in neuroimmunology and glia research and the programming that has been in place since the establishment of the center from Brain Immmunolgy and Glia (BIG) in 2012. The BIGTP brings together 20 mentors from eight different departments with the goal of providing interdisciplinary training that sparks discoveries and prepares a generation of researchers that are uniquely equipped to tackle research questions that arise at the interface of neuroscience and immunology. Funds are requested to support two predoctoral trainees each year for a duration of two years, typically in years three and four of graduate training. The 20 mentors are well-funded by a total of nearly $11 million in annual direct costs. The average mentor has trained more than nine pre- and postdoctoral trainees in the past ten years. Assistant Professors are included as Junior Mentors that will require senior BIGTP faculty to serve as co-mentors for trainees. Formal mentor training is required of all BIGTP mentors. Trainees will partake in the dynamic BIG research in progress seminars that are held weekly. Trainees will also have access to leaders in the field through the BIG Neuro seminar series. Annual retreats will focus on trainee development, review of the program, and will allow trainees to interact with members of the BIGTP External Advisory Board that are invited as keynote speakers. The quantitative literacy of trainees will be developed and supported through the Quantitative Literacy Series designed specifically for trainees that addresses topics in experimental design, reproducibility, power analysis, statistical analyses, transparency in reporting, etc. Importantly, Dr. Marieke Jones directs required courses in programming and statistical analyses and will be directly supported by and involved in BIGTP events, providing continuity in instruction and support for trainees for the duration of their predoctoral studies. The BIGTP will be evaluated by current and past trainees, program mentors, and members of a highly-qualified External Advisory Board. Predoctoral trainees trained in BIGTP mentor laboratories have completed their degrees in approximately 5.25 years and contributed to an average of 4.9 publications and 1.7 first-author publications in journals that include: Nature, Cell, Nature Neuroscience, Science Translational Medicine, Immunity, Neuron, PNAS, Science Advances, and Nature Communications. Current and past trainees have been supported by individual fellowships sponsored by NIH, NSF, and UVA. Importantly, 97% of trainees remain in science-related fields and 74% go on to complete further training. The BIGTP leadership and mentors understand the importance of diversity, which is essential for the strength and growth of the proposed Training Program. The BIGTP’s commitment to diversity is demonstrated by the inclusivity within the Program’s administration and programmatic events. The implementation of an NIH- sponsored T32 training program will allow existing strengths and programming at UVA to strengthen and expand to provide unparalleled training for predoctoral trainees in a burgeoning research area.