Brain, Immunology and Glia Training Program

项目总结 弗吉尼亚大学(UVA)的脑免疫学和Glia培训计划(BIGTP)将建立在 在神经免疫学和神经胶质研究方面的现有优势以及自 该中心由大脑免疫和Glia(BIG)于2012年建立。BIGTP汇集了20个 来自八个不同部门的导师，目标是提供跨学科的培训 发现并培养一代研究人员，他们拥有独特的装备来解决研究问题 出现在神经科学和免疫学的交界处。申请资金支持两名博士后 每年的受训者为期两年，通常是研究生培训的第三年和第四年。前20名 导师的资金充足，每年总共有近1100万美元的直接成本。平均每个导师都接受过培训 在过去的十年中，有九名博士后和博士后学员。助理教授被列为初级教授 导师将需要资深的BIGTP教职员工担任学员的联合导师。正式的导师培训是 对所有BIGTP导师都是必需的。学员将参加充满活力的正在进行的大型研究研讨会，这些研讨会是 每周举行一次。学员还将有机会通过大型神经研讨会系列接触到该领域的领导者。每年一次 务虚会将重点放在实习生的发展，计划的审查，并将允许实习生与成员互动 被邀请作为主旨演讲人的BIGTP外部咨询委员会成员。学员的量化素养 将通过专门为受训人员设计的量化扫盲系列得到开发和支持 讨论实验设计、可重复性、能量分析、统计分析、透明度等主题 重要的是，Marieke Jones博士指导编程和统计分析方面的必修课 并将直接得到BIGTP活动的支持和参与，提供持续的指导和支持 为实习生博士前学习期间提供服务。BIGTP将由现任和过去的学员进行评估， 计划导师，以及高素质的外部顾问委员会成员。受过培训的博士后学员 BIGTP导师实验室在大约5.25年内完成了他们的学位，并为 在包括《自然》、《细胞》、《自然》等期刊上平均发表4.9篇论文和1.7篇第一作者论文 神经科学、科学转化医学、免疫学、神经元、PNAs、科学进步和自然 通讯。现在和过去的受训者都得到了由NIH赞助的个人奖学金的支持， NSF和UVA。重要的是，97%的受训人员仍在与科学相关的领域，74%的受训人员继续深造 训练。BIGTP领导层和导师理解多样性的重要性，这对 拟议的培训计划的优势和增长。BIGTP对多样性的承诺得到了证明 方案管理和方案活动的包容性。实施了一项NIH- 赞助的T32培训计划将使UVA现有的优势和计划得到加强和扩大 在一个新兴的研究领域为博士前学员提供无与伦比的培训。

PROJECT SUMMARY The Brain Immunology ang Glia Training Program (BIGTP) at the University of Virginia (UVA) will build on existing strengths in neuroimmunology and glia research and the programming that has been in place since the establishment of the center from Brain Immmunolgy and Glia (BIG) in 2012. The BIGTP brings together 20 mentors from eight different departments with the goal of providing interdisciplinary training that sparks discoveries and prepares a generation of researchers that are uniquely equipped to tackle research questions that arise at the interface of neuroscience and immunology. Funds are requested to support two predoctoral trainees each year for a duration of two years, typically in years three and four of graduate training. The 20 mentors are well-funded by a total of nearly $11 million in annual direct costs. The average mentor has trained more than nine pre- and postdoctoral trainees in the past ten years. Assistant Professors are included as Junior Mentors that will require senior BIGTP faculty to serve as co-mentors for trainees. Formal mentor training is required of all BIGTP mentors. Trainees will partake in the dynamic BIG research in progress seminars that are held weekly. Trainees will also have access to leaders in the field through the BIG Neuro seminar series. Annual retreats will focus on trainee development, review of the program, and will allow trainees to interact with members of the BIGTP External Advisory Board that are invited as keynote speakers. The quantitative literacy of trainees will be developed and supported through the Quantitative Literacy Series designed specifically for trainees that addresses topics in experimental design, reproducibility, power analysis, statistical analyses, transparency in reporting, etc. Importantly, Dr. Marieke Jones directs required courses in programming and statistical analyses and will be directly supported by and involved in BIGTP events, providing continuity in instruction and support for trainees for the duration of their predoctoral studies. The BIGTP will be evaluated by current and past trainees, program mentors, and members of a highly-qualified External Advisory Board. Predoctoral trainees trained in BIGTP mentor laboratories have completed their degrees in approximately 5.25 years and contributed to an average of 4.9 publications and 1.7 first-author publications in journals that include: Nature, Cell, Nature Neuroscience, Science Translational Medicine, Immunity, Neuron, PNAS, Science Advances, and Nature Communications. Current and past trainees have been supported by individual fellowships sponsored by NIH, NSF, and UVA. Importantly, 97% of trainees remain in science-related fields and 74% go on to complete further training. The BIGTP leadership and mentors understand the importance of diversity, which is essential for the strength and growth of the proposed Training Program. The BIGTP’s commitment to diversity is demonstrated by the inclusivity within the Program’s administration and programmatic events. The implementation of an NIH- sponsored T32 training program will allow existing strengths and programming at UVA to strengthen and expand to provide unparalleled training for predoctoral trainees in a burgeoning research area.