Brain, Immunology and Glia Training Program

大脑、免疫学和神经胶质细胞培训计划

• 批准号: 10614558
• 负责人: TAJIE H. HARRIS
• 金额: $ 24.7万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614558
• 关键词: Brain; Immunology; Neuroglia; Training Programs

PROJECT SUMMARY The Brain Immunology ang Glia Training Program (BIGTP) at the University of Virginia (UVA) will build on existing strengths in neuroimmunology and glia research and the programming that has been in place since the establishment of the center from Brain Immmunolgy and Glia (BIG) in 2012. The BIGTP brings together 20 mentors from eight different departments with the goal of providing interdisciplinary training that sparks discoveries and prepares a generation of researchers that are uniquely equipped to tackle research questions that arise at the interface of neuroscience and immunology. Funds are requested to support two predoctoral trainees each year for a duration of two years, typically in years three and four of graduate training. The 20 mentors are well-funded by a total of nearly $11 million in annual direct costs. The average mentor has trained more than nine pre- and postdoctoral trainees in the past ten years. Assistant Professors are included as Junior Mentors that will require senior BIGTP faculty to serve as co-mentors for trainees. Formal mentor training is required of all BIGTP mentors. Trainees will partake in the dynamic BIG research in progress seminars that are held weekly. Trainees will also have access to leaders in the field through the BIG Neuro seminar series. Annual retreats will focus on trainee development, review of the program, and will allow trainees to interact with members of the BIGTP External Advisory Board that are invited as keynote speakers. The quantitative literacy of trainees will be developed and supported through the Quantitative Literacy Series designed specifically for trainees that addresses topics in experimental design, reproducibility, power analysis, statistical analyses, transparency in reporting, etc. Importantly, Dr. Marieke Jones directs required courses in programming and statistical analyses and will be directly supported by and involved in BIGTP events, providing continuity in instruction and support for trainees for the duration of their predoctoral studies. The BIGTP will be evaluated by current and past trainees, program mentors, and members of a highly-qualified External Advisory Board. Predoctoral trainees trained in BIGTP mentor laboratories have completed their degrees in approximately 5.25 years and contributed to an average of 4.9 publications and 1.7 first-author publications in journals that include: Nature, Cell, Nature Neuroscience, Science Translational Medicine, Immunity, Neuron, PNAS, Science Advances, and Nature Communications. Current and past trainees have been supported by individual fellowships sponsored by NIH, NSF, and UVA. Importantly, 97% of trainees remain in science-related fields and 74% go on to complete further training. The BIGTP leadership and mentors understand the importance of diversity, which is essential for the strength and growth of the proposed Training Program. The BIGTP’s commitment to diversity is demonstrated by the inclusivity within the Program’s administration and programmatic events. The implementation of an NIH- sponsored T32 training program will allow existing strengths and programming at UVA to strengthen and expand to provide unparalleled training for predoctoral trainees in a burgeoning research area.

项目概要 弗吉尼亚大学 (UVA) 的脑免疫学和神经胶质细胞培训计划 (BIGTP) 将建立在 神经免疫学和神经胶质细胞研究的现有优势以及自 2012 年，脑免疫和胶质细胞 (BIG) 中心成立。BIGTP 汇集了 20 来自八个不同部门的导师，旨在提供激发灵感的跨学科培训 发现并培养一代具有独特能力来解决研究问题的研究人员 出现在神经科学和免疫学的交汇处。申请资金支持两名博士前 每年接受为期两年的培训，通常在研究生培训的第三年和第四年。 20 号 导师资金充足，每年直接费用总计近 1100 万美元。平均导师受过训练 近十年来培养博士前、博士后9名以上。助理教授被列为初级教授 导师将要求 BIGTP 高级教师担任学员的共同导师。正规的导师培训是 所有 BIGTP 导师都需要。学员将参加动态 BIG 研究进展研讨会 每周举行一次。学员还将通过 BIG Neuro 研讨会系列接触到该领域的领导者。年度的 务虚会的重点是学员发展、计划审查，并允许学员与会员互动 BIGTP 外部顾问委员会的成员被邀请作为主旨发言人。学员的定量素养 将通过专门为学员设计的定量读写能力系列来开发和支持 讨论实验设计、再现性、功效分析、统计分析、透明度等主题 报告等。重要的是，Marieke Jones 博士指导编程和统计分析方面的必修课程 并将直接受到 BIGTP 活动的支持并参与其中，提供指导和支持的连续性 供博士前研究期间的实习生使用。 BIGTP 将由当前和过去的学员进行评估， 项目导师和高素质的外部顾问委员会成员。博士前培训生接受过培训 BIGTP 导师实验室在大约 5.25 年内完成了学位，并为 平均在以下期刊发表 4.9 篇论文和 1.7 篇第一作者论文，其中包括：Nature、Cell、Nature 神经科学、科学转化医学、免疫、神经元、PNAS、科学进展和自然 通讯。当前和过去的学员均获得 NIH 赞助的个人奖学金的支持， NSF 和 UVA。重要的是，97% 的学员仍留在科学相关领域，74% 继续完成进一步学业 训练。 BIGTP 领导层和导师了解多样性的重要性，这对于 拟议培训计划的强度和成长。 BIGTP 对多样性的承诺得到了体现 通过该计划的管理和计划活动的包容性。 NIH 的实施 赞助的 T32 培训计划将使 UVA 的现有优势和规划得到加强和扩展 为新兴研究领域的博士前学员提供无与伦比的培训。

项目成果

Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.

成年小鼠脑中少突胶质细胞祖细胞异质性的证据。

• DOI: 10.1038/s41598-022-17081-7
• 发表时间: 2022-07-28
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Beiter, Rebecca M.;Rivet-Noor, Courtney;Merchak, Andrea R.;Bai, Robin;Johanson, David M.;Slogar, Erica;Sol-Church, Katia;Overall, Christopher C.;Gaultier, Alban
• 通讯作者: Gaultier, Alban