Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination

评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响

• 批准号: 10441118
• 负责人: PHILIPPE ADAM GRANDJEAN
• 金额: $ 125万
• 依托单位: SILENT SPRING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441118
• 关键词: Assessment; PFAS; exposures; health; effects

ABSTRACT Across the U.S., a growing number of drinking water supplies have been found to be contaminated with per- and polyfluoroalkyl substances (PFAS). We first found that at least six million Americans in 22 states receive drinking water from sources that exceeded EPA’s 2016 guideline for PFOS and PFOA, and over 100 million Americans are estimated to have PFAS in their tap water. Over 400 DoD sites have known or suspected releases of PFAS. Our team found that proximity to military fire training areas and airports strongly predicts drinking water contamination due to the use of PFAS-containing aqueous film-forming foam (AFFF) for liquid fuel fires. Health concerns related to PFOA and PFOS include cancer, liver toxicity, high cholesterol, and reproductive and developmental effects. Following our first report on immunotoxicity, a 2016 National Toxicology Program systematic review concluded that both PFOS and PFOA are presumed immune hazards to humans. While elevated total cholesterol has been associated with PFAS exposure, our preliminary evidence suggests associations with specific lipoprotein subfractions that predict risk of cardiovascular disease. Despite the growing number of communities with documented PFAS exposures, there have been few epidemiological studies in communities with PFAS-impacted drinking water. As part of ATSDR’s multi-site study of health effects associated with exposures to PFAS-contaminated drinking water, we propose a study of PFAS health effects in two communities in Eastern Massachusetts where public drinking water supplies have been contaminated by PFAS from AFFF use at nearby fire training areas. Our proposal includes a combination of required elements according to ATSDR’s protocol and novel components, such as applying total extractable organofluorine (EOF) and non-targeted screening methods to provide a more complete assessment of PFAS exposures and analyzing lipoprotein fractions, body fat measurements, and metabolomics markers of lipid metabolism. Research partners include Silent Spring Institute, Harvard T.H. Chan School of Public Health, and Eastern Research Group, and community partner organizations include Massachusetts Breast Cancer Coalition (MBCC) in Hyannis and People of Ayer Concerned about the Environment (PACE). The primary aims are: Aim 1. Evaluate serum-PFAS levels, serum biomarkers of effects, and neurobehavioral outcomes in 1,000 adults and 350 children in two communities with AFFF contamination of public water supplies. Aim 2. Measure total extractable organofluorine and non-targeted PFAS profiles in blood samples from children and adults to provide a more complete assessment of total PFAS exposures. Aim 3. Evaluate associations between measured and estimated PFAS exposures and markers of elevated disease risks, such as lipoprotein subfractions, metabolomics markers of lipid metabolism, body fat measurements, and antibody concentrations.

抽象的 在美国各地，越来越多的饮用水源被发现受到污染 全氟烷基物质和多氟烷基物质 (PFAS)。我们首先发现 22 个州至少有 600 万美国人 从超过 EPA 2016 年 PFOS 和 PFOA 指南的来源获取饮用水，并且超过 100 据估计，有 100 亿美国人的自来水中含有 PFAS。超过 400 个 DoD 站点已知或 疑似释放 PFAS。我们的团队发现，靠近军事消防训练区和机场的位置强烈 预测由于使用含 PFAS 的水成膜泡沫 (AFFF) 造成饮用水污染 液体燃料起火。与 PFOA 和 PFOS 相关的健康问题包括癌症、肝毒性、高胆固醇和 生殖和发育影响。继我们第一份关于免疫毒性的报告之后，2016 年国家 毒理学计划系统审查得出的结论是，PFOS 和 PFOA 均被推定为免疫危害 对人类。虽然总胆固醇升高与 PFAS 暴露有关，但我们初步认为 有证据表明与预测心血管风险的特定脂蛋白亚组分有关 疾病。尽管越来越多的社区记录了 PFAS 暴露情况，但很少有社区 饮用水受 PFAS 影响的社区的流行病学研究。 作为 ATSDR 对与接触 PFAS 污染相关的健康影响的多地点研究的一部分 饮用水，我们提议对马萨诸塞州东部两个社区的 PFAS 健康影响进行研究 公共饮用水供应因附近消防训练中使用的水成膜泡沫而被 PFAS 污染 地区。我们的提案包括根据 ATSDR 协议和新颖的所需元素的组合 成分，例如应用总可萃取有机氟 (EOF) 和非靶向筛选方法 提供更完整的 PFAS 暴露评估并分析脂蛋白组分、身体脂肪 脂质代谢的测量和代谢组学标记。研究合作伙伴包括《寂静的春天》 哈佛大学 T.H. 研究所陈公共卫生学院、东方研究小组和社区合作伙伴 组织包括海恩尼斯的马萨诸塞州乳腺癌联盟 (MBCC) 和艾尔人民 关注环境（PACE）。主要目标是： 目标 1. 评估血清 PFAS 水平、影响的血清生物标志物和神经行为结果 两个社区的 1,000 名成人和 350 名儿童的公共供水受到水成膜泡沫污染。 目标 2. 测量血液样本中的总可提取有机氟和非目标 PFAS 特征 来自儿童和成人的数据，以提供对 PFAS 总暴露量的更完整的评估。 目标 3. 评估测量和估计的 PFAS 暴露量与标记物之间的关联 疾病风险升高，例如脂蛋白亚组分、脂质代谢的代谢组学标记物、 体脂肪测量和抗体浓度。