Glucose Metabolism in Adults Prenatally Exposed to Diabetogenic Pollutants

产前暴露于致糖尿病污染物的成人的葡萄糖代谢

• 批准号: 8886731
• 负责人: PHILIPPE ADAM GRANDJEAN
• 金额: $ 20.56万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2015-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8886731
• 关键词: Accounting; Acids; Address; Adult; Affect; Age; Benchmarking; Beta Cell; Birth; Body Composition; Body Weight Changes; Budgets; Candidate Disease Gene; Cellular Stress; Chemicals; Child; Chlorinated Hydrocarbons; Clinical; Computer Simulation; Data; Development; Diabetes Mellitus; Diet; Documentation; Dose; Elderly; Environmental Epidemiology; Epidemiologic Studies; Etiology; Evaluation; Exposure to; Fasting; Genes; Genetic; Genetic Predisposition to Disease; Genetic study; Genotype; Glucose; Goals; Health; Heterogeneity; Hexachlorobenzene; Human; Individual; Informed Consent; Insulin; Lead; Life Style; Link; Links List; Metabolic; Metabolic syndrome; Monograph; Mutation; National Research Council; National Toxicology Program; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Overweight; Ozone; Parents; Pathogenesis; Phase; Phenotype; Plasma; Polychlorinated Biphenyls; Population; Prediabetes syndrome; Predisposition; Prevalence; Program Reviews; Public Health; Publishing; Research; Risk; Risk Assessment; Role; Source; Statutes and Laws; Sulfur Oxides; Systems Biology; Tetrachlorodibenzodioxin; Uncertainty; World Health Organization; cohort; environmental chemical; epigenetic marker; fasting plasma glucose; flexibility; follow-up; gene environment interaction; genetic variant; glucose metabolism; innovation; insulin sensitivity; laboratory facility; member; parent grant; parent project; pollutant; postnatal; prenatal; prenatal exposure; programs; public health relevance; research study; response; young adult

 DESCRIPTION (provided by applicant): The overall goal of the parent proposal is to assess whether developmental (prenatal or early postnatal) exposure to environmental chemicals may be associated with the development of altered glucose metabolism, decreased insulin sensitivity, metabolic inflexibility, and early clinical signs of metabolic syndrome development in a Faroese birth cohort by age 27-28 years. The present - Revision: analyses suggest may cause gene-environment interactions in regard to environmentally associated type 2 diabetes. The targeted approach is in accordance with Faroese legislation and allows a focus on a curated list of linked genes and environmental chemicals for possible gene- environment interaction. Using genetic laboratory facilities at HSPH and relying on the ongoing parent study, where informed consent includes genetic studies, this Revision will address the question whether heterogeneities of candidate genes may modify the glucose metabolism phenotype as potentially affected by exposures to diabetogenic organohalogen compounds. The results will also contribute to the assessment of genetic impact on individual susceptibility and the use of default uncertainty factors in risk assessment.

 描述（由申请人提供）：母提案的总体目标是评估发育（产前或产后早期）暴露于环境化学品是否可能与以下疾病的发生相关：葡萄糖代谢改变、胰岛素敏感性降低、代谢紊乱和代谢综合征的早期临床体征。 a按27-28岁法罗群岛出生队列分列。目前的修订：分析表明，可能会导致环境相关的2型糖尿病的基因-环境相互作用。有针对性的方法符合法罗群岛的立法，并允许重点关注可能的基因-环境相互作用的相关基因和环境化学品的策划清单。利用HSPH的遗传实验室设施，并依靠正在进行的母研究，其中知情同意包括遗传研究，本修订版将解决候选基因的异质性是否可能改变葡萄糖代谢表型的问题，因为暴露于致糖尿病的有机卤素化合物可能会受到影响。这些结果也将有助于评估遗传对个体易感性的影响，以及在风险评估中使用默认的不确定性因素。