Critical effects associated with developmental PFAS exposure profiles
与发育 PFAS 接触情况相关的关键影响
基本信息
- 批准号:10352511
- 负责人:
- 金额:$ 36.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:14 year old5 year old9 year oldAchievementAdaptive Immune SystemAdultAdverse effectsAffectAgeAge-MonthsAntibodiesAntibody FormationAntibody ResponseApolipoproteins CBiological MarkersBirthBloodBlood specimenBone Mineral ContentsBreast FeedingCOVID-19 severityChildChildhoodCholesterolClinicalClinical DataCohort StudiesCommunicable DiseasesComplementDataDependenceDevelopmentDual-Energy X-Ray AbsorptiometryEndocrineEndocrine disruptionEnvironmental PollutantsEnvironmental PollutionEquationEtiologyExposure toFaeroe IslandsFrequenciesGeneral PopulationGoalsHealthHumanHuman DevelopmentHuman MilkHuman Papilloma Virus VaccineImmuneImmune System DiseasesImmune systemImmunologic MarkersIncidenceInfectionInflammationInsulin-Like Growth Factor IJointsLactationLeadLifeLinkLipidsLymphocyte CountMeasuresMetabolicMetabolic DiseasesModelingNon-Insulin-Dependent Diabetes MellitusObesityOsteoporosisOutcomePathogenesisPathway interactionsPatternPlayPoly-fluoroalkyl substancesPrediabetes syndromePredispositionPregnancyPreventionProspective StudiesPubertyPublic HealthRegression AnalysisReportingResearchRiskRisk AssessmentRoleSamplingScanningSerumSerum MarkersSignal Recognition ParticleSkinfold ThicknessSourceStatistical MethodsTimeToxoidsUmbilical Cord BloodVaccinationVaccinesadipokinesclinical examinationclinical phenotypeclinically relevantcohortearly life exposureenvironmental chemicalepidemiology studyimmune functionimmune system functionimmunotoxicityimprovedinfancyinflammatory markerinsightnext generationpostnatalprenatalprospectivesexual dimorphismvaccine failurevaccine-induced antibodies
项目摘要
PROJECT SUMMARY/ABSTRACT – PROJECT 2 CRITICAL EFFECTS
Metabolic diseases, including obesity and type 2 diabetes, are major public health problems of multifactorial
etiology, in which early-life exposures to environmental pollutants, such as per- and polyfluoroalkyl substances
(PFAS), appear to play a role. In parallel, a critical effect of PFAS exposure is immunotoxicity that paves the
way for immune dysfunction and infectious disease. STEEP Project 2 (P2–Critical Effects) will examine the
role of developmental exposure profiles for these high-priority environmental pollutants and determine
outcomes up to ages 5 and 14 years to allow identification of windows of susceptibility. We will rely on two birth
cohorts from the Faroe Islands (total N >1000) to prospectively explore the associations between exposure
profiles of PFAS and outcomes, including immune deficiencies (suboptimal antibody production after
vaccinations, and increased frequency of infectious disease) and metabolic abnormalities (excess adiposity,
hyperlipidaemia, low bone mineral content, and prediabetes). P2–Critical Effects will further evaluate the
possible usefulness of clinically relevant biomarkers in serum (such as cholesterol subfractions,
adipocytokines, insulin-like growth factor-1). Exposure data are already available from analyses of maternal
pregnancy, cord blood and postnatal serum at ages 18 months, 5 and 9 years from the oldest Cohort 5, and
clinical data, including DXA scans, are available for comparisons with age 14 years. The youngest Cohort 6 is
currently being formed, with blood samples and human milk being taken during infancy for PFAS analyses that
will allow determination of PFAS transfer from lactation. Multiple regression analyses with adjustment for other
environmental chemicals will be complemented by structural equation models and other advanced statistical
methods. Thus, the proposed study will aim at providing prevention potentials and new insights into the
pathogenesis of major public health problems that are associated with early-life exposures to high-priority
environmental pollutants.
项目总结/摘要-项目2关键效应
代谢性疾病,包括肥胖和2型糖尿病,是多因素影响的主要公共卫生问题。
病因学,其中生命早期暴露于环境污染物,如全氟烷基和多氟烷基物质
(PFAS),似乎发挥了作用。与此同时,PFAS暴露的一个关键影响是免疫毒性,
免疫功能障碍和传染病的途径。STEEP项目2(P2-关键影响)将检查
这些高度优先的环境污染物的发展接触概况的作用,并确定
5岁和14岁的结果,以便识别易感性窗口。我们将依靠两个出生
来自法罗群岛的队列(总数N >1000)前瞻性探索暴露之间的关联
PFAS的特征和结果,包括免疫缺陷(免疫缺陷后的次优抗体产生)
接种疫苗,以及感染性疾病的频率增加)和代谢异常(过度肥胖,
糖尿病、低骨矿物质含量和前驱糖尿病)。P2-临界效应将进一步评估
血清中临床相关生物标志物(例如胆固醇亚组分,
脂肪细胞因子、胰岛素样生长因子-1)。通过对孕妇的分析,已经获得了接触数据。
年龄最大队列5的18个月、5岁和9岁时的妊娠、脐带血和出生后血清,以及
临床数据,包括DXA扫描,可用于与14岁的年龄进行比较。最年轻的第6组是
目前正在形成,在婴儿期采集血样和人乳进行PFAS分析,
将允许测定从泌乳转移的PFAS。调整其他因素的多元回归分析
环境化学品将由结构方程模型和其他先进的统计方法补充。
方法.因此,拟议的研究将旨在提供预防潜力和对
与生命早期暴露于高优先级环境相关的重大公共卫生问题的发病机制
环境污染物
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PHILIPPE ADAM GRANDJEAN其他文献
PHILIPPE ADAM GRANDJEAN的其他文献
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{{ truncateString('PHILIPPE ADAM GRANDJEAN', 18)}}的其他基金
Vulnerability During Infancy to Immunotoxic Contaminant Exposures
婴儿期对免疫毒性污染物暴露的脆弱性
- 批准号:
10337281 - 财政年份:2020
- 资助金额:
$ 36.67万 - 项目类别:
Vulnerability During Infancy to Immunotoxic Contaminant Exposures
婴儿期对免疫毒性污染物暴露的脆弱性
- 批准号:
9885685 - 财政年份:2020
- 资助金额:
$ 36.67万 - 项目类别:
Vulnerability During Infancy to Immunotoxic Contaminant Exposures
婴儿期对免疫毒性污染物暴露的脆弱性
- 批准号:
10737655 - 财政年份:2020
- 资助金额:
$ 36.67万 - 项目类别:
Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响
- 批准号:
10021527 - 财政年份:2019
- 资助金额:
$ 36.67万 - 项目类别:
Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响
- 批准号:
10471152 - 财政年份:2019
- 资助金额:
$ 36.67万 - 项目类别:
Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响
- 批准号:
10220767 - 财政年份:2019
- 资助金额:
$ 36.67万 - 项目类别:
Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响
- 批准号:
10268149 - 财政年份:2019
- 资助金额:
$ 36.67万 - 项目类别:
Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响
- 批准号:
10441118 - 财政年份:2019
- 资助金额:
$ 36.67万 - 项目类别:
Inflammation and metabolic abnormalities in pollutant-exposed children
接触污染物的儿童的炎症和代谢异常
- 批准号:
9239171 - 财政年份:2017
- 资助金额:
$ 36.67万 - 项目类别:
Critical effects associated with developmental PFAS exposure profiles
与发育 PFAS 接触情况相关的关键影响
- 批准号:
10704011 - 财政年份:2017
- 资助金额:
$ 36.67万 - 项目类别:
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