Impacts of Urbanization on Vector Biology and Transmission of Dengue in China

项目摘要 城市化对媒介生物学和生物多样性的影响 登革热在中国的传播 登革热是一种急性传染病，由登革热病毒和 由伊蚊传播。尽管中国的控制程序很紧张，但少校 近日，南部中国市区发生登革热疫情。控制 控制蚊子种群是预防登革热的唯一可用策略，因为 目前还没有治疗登革热的有效药物。化学杀虫剂的使用代表着 中国和全世界登革热病媒控制的最重要因素。我们的 初步数据显示，在登革热病媒中，拟除虫菊酯耐药性迅速上升。 市区南部的中国。这一竞争对手的续订申请将测试 中心假设频繁的登革热暴发和密集的杀虫剂使用 导致城市环境中杀虫剂的出现和传播 登革热媒介的耐药性，这反过来又增加了媒介种群 登革热的密度和媒介容量。我们提出了三个相互关联的具体方案 目的：1)确定城乡登革热媒介人群的抵抗力水平 环境，2)开发用于抗药性监测的新分子工具 通过更好地了解抗性机制，并进行分子 监测城市和农村环境中的杀虫剂耐药性，以及3) 确定杀虫剂抗药性对蚊子生存的影响，媒介 城市和农村环境中的能力和媒介能力。我们将重点关注 白纹伊蚊是一种高度入侵的物种，也是我国最重要的登革热媒介 南方的中国。来自该项目的知识和工具将有助于指导 选择杀虫剂控制登革热媒介，促进抗药性 监测和管理，并加强我们对登革热流行病学的了解 在城市环境中，杀虫剂耐药性正在迅速增加。

Project Summary Title: Impacts of Urbanization on Vector Biology and Transmission of Dengue in China Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by Aedes mosquitoes. Despite the intense control program in China, major dengue outbreaks have recently occurred in the urban area of Southern China. Control of mosquito populations is the only available strategy for prevention of dengue because there are no effective drugs for dengue. The use of chemical insecticides represents the most important element of vector control for dengue in China and worldwide. Our preliminary data indicates a rapid rise of pyrethroid resistance in the dengue vectors in urban areas of southern China. This competing renewal application will test the central hypothesis that frequent dengue outbreaks and intensive insecticide use in the urban environment lead to an emergence and spread of insecticide resistance in the dengue vector, which in turn increases vector population density and vectorial capacity for dengue. We proposed three interlinked specific aims: 1) to determine resistance level of dengue vector populations in urban and rural environments, 2) to develop new molecular tools for insecticide resistance surveillance through a better understanding of resistance mechanisms, and to conduct molecular surveillance of insecticide resistance in urban and rural environments, and 3) to determine the effect of insecticide resistance on mosquito survivorship, vector competence and vectorial capacity in urban and rural environments. We will focus on Aedes albopictus, a highly invasive species and the most important dengue vector in Southern China. The knowledge and tools from this project will help in guiding the selection of insecticides for dengue vector control, facilitate insecticide resistance surveillance and management, and enhance our understanding of dengue epidemiology in the urban environment where insecticide resistance is rapidly increasing.