Heightened Performance Monitoring and Overcontrol: Neural Markers and Caregiving Processes in Developmental Risk Trajectories

加强绩效监控和过度控制：发育风险轨迹中的神经标记和护理过程

• 批准号: 9751968
• 负责人: Kirsten Gilbert
• 金额: $ 15.33万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751968
• 关键词: Adolescence; Affect; Affective; Age; Anorexia; Anorexia Nervosa; Anxiety; Behavior Disorders; Behavioral; Behavioral inhibition; Biological; Biological Markers; Characteristics; Child; Chronic; Clinical; Cognitive; Comorbidity; Development; Developmental Course; Disease; Early Intervention; Emotional; Environment; Event-Related Potentials; Exhibits; Feedback; Goals; Impairment; Intervention; Intervention Studies; Knowledge; Link; Literature; Mental disorders; Mentors; Mentorship; Methodology; Methods; Modeling; Monitor; National Institute of Mental Health; Obsessive-Compulsive Disorder; Onset of illness; Outcome; Parents; Performance; Phenotype; Positive Valence; Preventive Intervention; Process; Psychopathology; Reporting; Research; Research Design; Research Domain Criteria; Resistance; Rewards; Risk; Schools; Self-control as a personality trait; Social Anxiety Disorder; Social Functioning; Strategic Planning; Symptoms; System; Techniques; Testing; Training; Translating; Ulysses Contracts; Work; Youth; aged; caregiving; chronic depression; clinical translation; cognitive control; cognitive system; early childhood; flexibility; high risk; indexing; longitudinal analysis; longitudinal design; neural correlate; neurophysiology; novel; programs; recruit; relating to nervous system; reward anticipation; social; social anxiety; social deficits; symptomatology; therapy development

PROJECT SUMMARY Social anxiety disorder, obsessive-compulsive disorder (OCD), anorexia nervosa, and chronic depression are all debilitating, chronic, and often treatment-resistant mental disorders that are characterized by high rates of comorbidity. These disorders also share an underlying transdiagnostic cognitive and emotional processing style, namely, heightened performance monitoring and overcontrol (Research Domain Criteria (RDoC) Cognitive Systems: Cognitive Control: Performance Monitoring). Little is known of how this underlying characteristic of heightened performance monitoring and overcontrol (HPM/OC) develops in early childhood prior to disorder onset. Moreover, it is largely unknown how this transdiagnostic construct contributes to increasing symptoms of psychopathology and social impairment in young children. This knowledge may provide meaningful targets for preventive intervention of multiple disorders. Consistent with the NIMH Strategic plan, particularly Strategy Objective 2, to “chart mental illness trajectories to determine when, where, and how to intervene,” this K23 application aims to identify neural markers and caregiving processes associated with developmental risk trajectories of HPM/OC in young children. Under the mentorship of a diverse team of experts in neurophysiological methods, developmental and caregiving processes in early childhood, longitudinal and statistical methodology, and treatment of overcontrol, this proposal will examine the developmental psychopathology of this NIMH RDoC construct in children age 5-6 during the transition to school. Specifically, this proposal will use event-related potentials (ERPs) to identify neural markers of HPM/OC and parent-child observational interactions to assess caregiving styles and dyadic features. Children will be assessed two years later to investigate how neural markers and caregiving styles predict symptoms of social anxiety, OCD and social impairment. Findings will inform the developmental course of this RDoC construct in relation to trajectories of mental illness. The long-term goal is to understand the biological and behavioral development of HPM/OC from early ages through adolescence so as to inform interventions directly targeting HPM/OC prior to disorder onset. Mentored training will allow the applicant to gain expertise in ERP methods and analysis, developmental psychopathology and caregiving processes in young children, longitudinal design and analysis, and training in clinical translation to begin mechanistically identifying and targeting youth with HPM/OC for early intervention.

项目摘要 社交焦虑症、强迫症（OCD）、神经性厌食症和慢性抑郁症是 所有使人衰弱的、慢性的、通常是难以治疗的精神障碍，其特征是高发病率， 科摩罗。这些疾病也共享一个潜在的跨诊断认知和情绪处理 风格，即加强性能监控和过度控制（研究领域标准（RDoC）） 认知系统：认知控制：性能监控）。很少有人知道这种潜在的 一个特征是在幼儿期发展出一种高度的表现监控和过度控制（HPM/OC） 在疾病发作之前。此外，很大程度上还不清楚这种转诊断结构如何有助于 幼儿的精神病理学和社会障碍症状增加。这些知识并 为多种疾病的预防性干预提供有意义的目标。符合NIMH战略 计划，特别是战略目标2，“绘制精神疾病轨迹，以确定何时、何地和如何 这项K23应用旨在识别与以下疾病相关的神经标记物和神经过程： 幼儿HPM/OC的发展风险轨迹。在一个多元化团队的指导下， 神经生理学方法、儿童早期发育和发育过程方面的专家， 纵向和统计方法，以及过度控制的处理，本提案将审查 NIMH RDoC结构在5-6岁儿童中的发展精神病理学， 学校具体来说，这项建议将使用事件相关电位（ERP）来识别神经标记物， HPM/OC和亲子观察互动来评估护理方式和二元特征。儿童 将在两年后进行评估，以研究神经标记物和咀嚼方式如何预测 社交焦虑、强迫症和社交障碍。调查结果将告知本RDoC的发展过程 与精神疾病发展轨迹的关系。长期目标是了解生物学和 HPM/OC从早期到青春期的行为发展，以便直接告知干预措施 在病症发作之前靶向HPM/OC。辅导培训将使申请人获得ERP方面的专业知识 方法和分析，发展精神病理学和幼儿的发育过程， 纵向设计和分析，以及临床翻译培训，以便开始机械地识别和 以青少年为对象，进行早期干预。